(data stored in ACNUC7421 zone)

HOGENOM: MOUSE13_PE735

ID   MOUSE13_PE735                        STANDARD;      PRT;   314 AA.
AC   MOUSE13_PE735; Q9JLZ3; Q80YD7; Q8QZS0; Q9CY78; Q9D155;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Methylglutaconyl-CoA hydratase, mitochondrial; EC=4.2.1
DE   18;AltName: Full=AU-specific RNA-binding enoyl-CoA hydratase;
DE   Short=AU-binding enoyl-CoA hydratase; Short=muAUH;Flags: Precursor;
DE   (MOUSE13.PE735).
GN   Name=Auh;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE13.PE735.
CC       Mus musculus chromosome 13 NCBIM37  sequence 1..120284312 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:AUHM_MOUSE
CC   -!- FUNCTION: Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-
CC       hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase
CC       activity. Was originally identified as RNA-binding protein that
CC       binds in vitro to clustered 5'-AUUUA-3' motifs (By similarity).
CC   -!- CATALYTIC ACTIVITY: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-
CC       methylglutaconyl-CoA + H(2)O.
CC   -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-
CC       hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3.
CC   -!- SUBUNIT: Homohexamer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q9JLZ3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9JLZ3-2; Sequence=VSP_008337, VSP_008340;
CC         Note=No experimental confirmation available;
CC       Name=3;
CC         IsoId=Q9JLZ3-3; Sequence=VSP_008338, VSP_008339;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Detected in heart, brain, liver, spleen,
CC       skeletal muscle and kidney.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC   -!- GENE_FAMILY: HOG000027939 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000021460;ENSMUST00000021913;ENSMUSP00000021913.
DR   EMBL; AF118386; - ;
DR   EMBL; AK003929; - ;
DR   EMBL; AK019978; - ;
DR   EMBL; BC026525; - ;
DR   EMBL; BC049597; - ;
DR   UniProtKB/Swiss-Prot; Q9JLZ3; Q80YD7; Q8QZS0; Q9CY78; Q9D155; -.
DR   EMBL; AF118386; AAF28835.1; -; mRNA.
DR   EMBL; AK003929; BAB23078.1; -; mRNA.
DR   EMBL; AK019978; BAB31947.1; -; mRNA.
DR   EMBL; BC026525; AAH26525.1; -; mRNA.
DR   EMBL; BC049597; AAH49597.1; -; mRNA.
DR   IPI; IPI00124900; -.
DR   IPI; IPI00357510; -.
DR   IPI; IPI00357511; -.
DR   RefSeq; NP_057918.2; NM_016709.2.
DR   UniGene; Mm.252034; -.
DR   ProteinModelPortal; Q9JLZ3; -.
DR   SMR; Q9JLZ3; 49-314.
DR   STRING; Q9JLZ3; -.
DR   PhosphoSite; Q9JLZ3; -.
DR   PRIDE; Q9JLZ3; -.
DR   GeneID; 11992; -.
DR   KEGG; mmu:11992; -.
DR   UCSC; uc007qnd.1; mouse.
DR   UCSC; uc007qnf.1; mouse.
DR   UCSC; uc007qng.1; mouse.
DR   CTD; 549; -.
DR   MGI; MGI:1338011; Auh.
DR   GeneTree; ENSGT00580000081296; -.
DR   InParanoid; Q9JLZ3; -.
DR   OrthoDB; EOG41JZD9; -.
DR   NextBio; 280169; -.
DR   ArrayExpress; Q9JLZ3; -.
DR   Bgee; Q9JLZ3; -.
DR   CleanEx; MM_AUH; -.
DR   Genevestigator; Q9JLZ3; -.
DR   GermOnline; ENSMUSG00000021460; Mus musculus.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; ISS:UniProtKB.
DR   GO; GO:0004490; F:methylglutaconyl-CoA hydratase activity; IEA:EC.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; ISS:UniProtKB.
DR   GO; GO:0009083; P:branched chain family amino acid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0000288; P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; TAS:MGI.
DR   InterPro; IPR014748; Crontonase_C.
DR   InterPro; IPR001753; Crotonase_core.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   Gene3D; G3DSA:1.10.12.10; Crontonase_C; 1.
DR   Pfam; PF00378; ECH; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
DR   HOGENOMDNA; MOUSE13.PE735; -.
KW   ENSMUSG000000214605old_1320000031; ENSMUSP000000219131old_1320000031;
KW   AF118386; AK003929; AK019978; BC026525; BC049597;
KW   Alternative splicing; Branched-chain amino acid catabolism;
KW   Complete proteome; Lyase; Mitochondrion; Reference proteome;
KW   RNA-binding; Transit peptide.
SQ   SEQUENCE   314 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAAAPGALG ALRTVGVRLV AACCARLGPA AWARGTAPRR GYSSEVKTED ELRVRHLEEE
     NRGIVVLGIN RAYGKNALSK NLLKMLSKAV DALKSDKKVR TIIIRSEVPG IFCAGADLKE
     RAKMHSSEVG PFVSKIRSVI NDIANLPVPT IAAIDGLALG GGLELALACD IRVAASSAKM
     GLVETKLAII PGGGGTQRLP RAIGMSLAKE LIFSARVLDG QEAKAVGLIS HVLEQNQEGD
     AAYRKALDLA REFLPQGPVA MRVAKLAINQ GMEVDLVTGL AIEEACYAQT ISTKDRLEGL
     LAFKEKRPPR YKGE
//

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