(data stored in ACNUC16935 zone)

HOGENOM: MOUSE14_PE1080

ID   MOUSE14_PE1080                       STANDARD;      PRT;   81 AA.
AC   MOUSE14_PE1080; P29595;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=NEDD8;AltName: Full=Neddylin;AltName: Full=Neural precursor
DE   cell expressed developmentally down-regulated protein 8;
DE   Short=NEDD-8;AltName: Full=Ubiquitin-like protein Nedd8;Flags: Precursor;
DE   (MOUSE14.PE1080).
GN   Name=Nedd8; Synonyms=Nedd-8;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE14.PE1080.
CC       Mus musculus chromosome 14 NCBIM37  sequence 1..125194864 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:NEDD8_MOUSE
CC   -!- FUNCTION: Ubiquitin-like protein which plays an important role in
CC       cell cycle control and embryogenesis. Covalent attachment to its
CC       substrates requires prior activation by the E1 complex UBE1C-
CC       APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to
CC       cullins activates their associated E3 ubiquitin ligase activity,
CC       and thus promotes polyubiquitination and proteasomal degradation
CC       of cyclins and other regulatory proteins.
CC   -!- SUBUNIT: Directly interacts with NUB1. Covalently attached to
CC       cullins and p53 (By similarity). Interacts with AHR.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Mainly nuclear.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed (at protein level).
CC   -!- DEVELOPMENTAL STAGE: According to PubMed:1378265 and
CC       PubMed:15183309, down-regulated during embryonic development, but
CC       according to PubMed:10597293, expression does not change during
CC       embryonic development. Between E10 and E12, expressed in heart and
CC       spinal ganglia. Between E13.5 and E16.5, strongly expressed in
CC       spinal and sympathetic ganglia, neural epithelium of the retina,
CC       oral and olfactory epithelia and thymus.
CC   -!- PTM: Cleavage of precursor form by UCHL3 or SENP8 is necessary for
CC       function (By similarity).
CC   -!- SIMILARITY: Belongs to the ubiquitin family.
CC   -!- GENE_FAMILY: HOG000233942 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000010376;ENSMUST00000010520;ENSMUSP00000010520.
DR   EMBL; AK146732; - ;
DR   EMBL; AK147080; - ;
DR   EMBL; AK158993; - ;
DR   EMBL; BC004625; - ;
DR   EMBL; CH466535; - ;
DR   EMBL; D10918; - ;
DR   UniProtKB/Swiss-Prot; P29595; -.
DR   EMBL; D10918; BAA01719.1; -; mRNA.
DR   EMBL; BC004625; AAH04625.1; -; mRNA.
DR   IPI; IPI00127021; -.
DR   PIR; JN0710; JN0710.
DR   RefSeq; NP_032709.1; NM_008683.3.
DR   UniGene; Mm.296566; -.
DR   ProteinModelPortal; P29595; -.
DR   SMR; P29595; 1-76.
DR   STRING; P29595; -.
DR   PhosphoSite; P29595; -.
DR   PRIDE; P29595; -.
DR   Ensembl; ENSMUST00000010520; ENSMUSP00000010520; ENSMUSG00000010376.
DR   Ensembl; ENSMUST00000163750; ENSMUSP00000130492; ENSMUSG00000010376.
DR   GeneID; 18002; -.
DR   KEGG; mmu:18002; -.
DR   CTD; 4738; -.
DR   MGI; MGI:97301; Nedd8.
DR   eggNOG; maNOG23639; -.
DR   InParanoid; P29595; -.
DR   OrthoDB; EOG4N04GQ; -.
DR   PhylomeDB; P29595; -.
DR   NextBio; 293003; -.
DR   ArrayExpress; P29595; -.
DR   Bgee; P29595; -.
DR   Genevestigator; P29595; -.
DR   GermOnline; ENSMUSG00000010376; Mus musculus.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0005515; F:protein binding; IPI:MGI.
DR   GO; GO:0008104; P:protein localization; IDA:MGI.
DR   GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI.
DR   InterPro; IPR000626; Ubiquitin.
DR   InterPro; IPR019954; Ubiquitin_CS.
DR   InterPro; IPR019956; Ubiquitin_subgr.
DR   InterPro; IPR019955; Ubiquitin_supergroup.
DR   Pfam; PF00240; ubiquitin; 1.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 1.
DR   PROSITE; PS00299; UBIQUITIN_1; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
DR   HOGENOMDNA; MOUSE14.PE1080; -.
KW   ENSMUSG000000103765old_1320000031; ENSMUSP000000105201old_1320000031;
KW   Q3TY05_MOUSE; Q3UI46_MOUSE; AK146732; AK147080; AK158993; BC004625;
KW   D10918;
KW   Acetylation; Complete proteome; Isopeptide bond; Nucleus;
KW   Reference proteome; Ubl conjugation pathway.
SQ   SEQUENCE   81 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MVLEQKTLTG KEIEIDIEPT DKVERIKERV EEKEGIPPQQ QRLIYSGKQM NDEKTAADYK
     ILGGSVLHLV LALRGGGGLG Q
//

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