(data stored in ACNUC30567 zone)

HOGENOM: MOUSE14_PE1318

ID   MOUSE14_PE1318                       STANDARD;      PRT;   735 AA.
AC   MOUSE14_PE1318; Q60718; Q60814; Q9D4G3; Q9QWJ0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Disintegrin and metalloproteinase domain-containing protein
DE   2; Short=ADAM 2;AltName: Full=Fertilin subunit beta;AltName: Full=PH-30;
DE   Short=PH30;AltName: Full=PH30-beta;Flags: Precursor; (MOUSE14.PE1318).
GN   Name=Adam2; Synonyms=Ftnb;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE14.PE1318.
CC       Mus musculus chromosome 14 NCBIM37  sequence 1..125194864 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ADAM2_MOUSE
CC   -!- FUNCTION: Sperm surface membrane protein that may be involved in
CC       sperm-egg plasma membrane adhesion and fusion during
CC       fertilization. Could have a direct role in sperm-zona binding or
CC       migration of sperm from the uterus into the oviduct. Interactions
CC       with egg membrane could be mediated via binding between its
CC       disintegrin-like domain to one or more integrins receptors on the
CC       egg. This is a non catalytic metalloprotease-like protein (By
CC       similarity).
CC   -!- SUBUNIT: Heterodimer with ADAM1/fertilin subunit alpha.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- TISSUE SPECIFICITY: Expressed specifically in testis.
CC   -!- DOMAIN: A tripeptide motif (QDE) within disintegrin-like domain
CC       could be involved in the binding to egg integrin receptor and thus
CC       could mediate sperm/egg binding (By similarity).
CC   -!- PTM: The signal and the metalloprotease domain are cleaved during
CC       the epididymal maturation of the spermatozoa.
CC   -!- SIMILARITY: Contains 1 disintegrin domain.
CC   -!- SIMILARITY: Contains 1 EGF-like domain.
CC   -!- SIMILARITY: Contains 1 peptidase M12B domain.
CC   -!- GENE_FAMILY: HOG000230883 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000022039;ENSMUST00000022618;ENSMUSP00000022618.
DR   EMBL; AK016550; - ;
DR   EMBL; AK161266; - ;
DR   EMBL; U16242; - ;
DR   EMBL; U22057; - ;
DR   EMBL; U38806; - ;
DR   UniProtKB/Swiss-Prot; Q60718; Q60814; Q9D4G3; Q9QWJ0; -.
DR   EMBL; U16242; AAA90980.1; -; mRNA.
DR   EMBL; U38806; AAD04207.1; -; mRNA.
DR   EMBL; AK016550; BAB30298.1; -; mRNA.
DR   EMBL; U22057; AAA74921.1; -; mRNA.
DR   IPI; IPI00378162; -.
DR   RefSeq; NP_033748.2; NM_009618.2.
DR   UniGene; Mm.422850; -.
DR   ProteinModelPortal; Q60718; -.
DR   SMR; Q60718; 179-651.
DR   STRING; Q60718; -.
DR   MEROPS; M12.950; -.
DR   PhosphoSite; Q60718; -.
DR   PRIDE; Q60718; -.
DR   Ensembl; ENSMUST00000022618; ENSMUSP00000022618; ENSMUSG00000022039.
DR   GeneID; 11495; -.
DR   KEGG; mmu:11495; -.
DR   UCSC; uc007uju.1; mouse.
DR   CTD; 2515; -.
DR   MGI; MGI:1340894; Adam2.
DR   GeneTree; ENSGT00590000082741; -.
DR   InParanoid; Q60718; -.
DR   OMA; DDINKCQ; -.
DR   OrthoDB; EOG49CQ78; -.
DR   NextBio; 278874; -.
DR   ArrayExpress; Q60718; -.
DR   Bgee; Q60718; -.
DR   CleanEx; MM_ADAM2; -.
DR   Genevestigator; Q60718; -.
DR   GermOnline; ENSMUSG00000022039; Mus musculus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:MGI.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0030534; P:adult behavior; IMP:MGI.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0008542; P:visual learning; IMP:MGI.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR001762; Blood-coag_inhib_Disintegrin.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR000742; EGF_3.
DR   InterPro; IPR024079; MetalloPept_cat_dom.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   Gene3D; G3DSA:4.10.70.10; Blood-coag_inhib_Disintegrin; 1.
DR   Gene3D; G3DSA:3.40.390.10; G3DSA:3.40.390.10; 1.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; Disintegrin; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS00022; EGF_1; FALSE_NEG.
DR   PROSITE; PS01186; EGF_2; FALSE_NEG.
DR   PROSITE; PS50026; EGF_3; 1.
DR   HOGENOMDNA; MOUSE14.PE1318; -.
KW   ENSMUSG000000220395old_1320000031; ENSMUSP000000226181old_1320000031;
KW   Q3TTP6_MOUSE; AK016550; AK161266; U16242; U22057; U38806;
KW   Cell adhesion; Complete proteome; Disulfide bond; EGF-like domain;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   735 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MWLILLLLSG LSELGGLSQS QTEGTREKLH VQVTVPEKIR SVTSNGYETQ VTYNLKIEGK
     TYTLDLMQKP FLPPNFRVYS YDNAGIMRSL EQKFQNICYF QGYIEGYPNS MVIVSTCTGL
     RGFLQFGNVS YGIEPLESSS GFEHVIYQVE PEKGGALLYA EKDIDLRDSQ YKIRSIKPQR
     IVSHYLEIHI VVEKQMFEHI GADTAIVTQK IFQLIGLANA IFAPFNLTVI LSSLEFWMDE
     NKILTTGDAN KLLYRFLKWK QSYLVLRPHD MAFLLVYRNT TDYVGATYQG KMCDKNYAGG
     VALHPKAVTL ESLAIILVQL LSLSMGLAYD DVNKCQCGVP VCVMNPEAPH SSGVRAFSNC
     SMEDFSKFIT SQSSHCLQNQ PRLQPSYKMA VCGNGEVEED EICDCGKKGC AEMPPPCCNP
     DTCKLSDGSE CSSGICCNSC KLKRKGEVCR LAQDECDVTE YCNGTSEVCE DFFVQNGHPC
     DNRKWICING TCQSGEQQCQ DLFGIDAGFG SSECFWELNS KSDISGSCGI SAGGYKECPP
     NDRMCGKIIC KYQSENILKL RSATVIYANI SGHVCVSLEY PQGHNESQKM WVRDGTVCGS
     NKVCQNQKCV ADTFLGYDCN LEKCNHHGVC NNKKNCHCDP TYLPPDCKRM KDSYPGGSID
     SGNKERAEPI PVRPYIASAY RSKSPRWPFF LIIPFYVVIL VLIGMLVKVY SQRMKWRMDD
     FSSEEQFESE SESKD
//

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