(data stored in ACNUC9552 zone)

HOGENOM: MOUSE14_PE995

ID   MOUSE14_PE995                        STANDARD;      PRT;   193 AA.
AC   MOUSE14_PE995; P70345; Q545Q4; Q6A093; Q8CFR2; Q8CGL4; Q9CYW5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Bcl-2-like protein 2; Short=Bcl2-L-2;AltName:
DE   Full=Apoptosis regulator Bcl-W;AltName: Full=c98; (MOUSE14.PE995).
GN   Name=Bcl2l2; Synonyms=Bclw, Kiaa0271;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE14.PE995.
CC       Mus musculus chromosome 14 NCBIM37  sequence 1..125194864 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:B2CL2_MOUSE
CC   -!- FUNCTION: Promotes cell survival. Blocks dexamethasone-induced
CC       apoptosis. Mediates survival of postmitotic Sertoli cells by
CC       suppressing death-promoting activity of BAX.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Peripheral membrane
CC       protein (By similarity). Note=Loosely associated with the
CC       mitochondrial membrane in healthy cells. During apoptosis, tightly
CC       bound to the membrane (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P70345-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P70345-2; Sequence=VSP_014780;
CC         Note=Ref.4 (BAB28740) sequence is in conflict in position:
CC         177:K->R;
CC   -!- TISSUE SPECIFICITY: Expressed in almost all myeloid cell lines and
CC       in a wide range of tissues, with highest levels in brain, colon,
CC       and salivary gland.
CC   -!- DEVELOPMENTAL STAGE: Expressed in both mitotic and postmitotic
CC       Sertoli cells.
CC   -!- INDUCTION: By Igf1.
CC   -!- DOMAIN: The BH4 motif seems to be involved in the anti-apoptotic
CC       function.
CC   -!- DOMAIN: The BH1 and BH2 motifs form a hydrophobic groove which
CC       acts as a docking site for the BH3 domain of some pro-apoptotic
CC       proteins. The C-terminal residues of BCL2L2 fold into the BH3-
CC       binding cleft and modulate pro-survival activity by regulating
CC       ligand access. When BH3 domain-containing proteins bind, they
CC       displace the C-terminus, allowing its insertion into the membrane
CC       and neutralizing the pro-survival activity of BCL2L2 (By
CC       similarity).
CC   -!- DISRUPTION PHENOTYPE: Mice are sterile due to arrest in
CC       spermatogenesis associated with a gradual loss of germ and Sertoli
CC       cells from the testis.
CC   -!- SIMILARITY: Belongs to the Bcl-2 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD32203.1; Type=Frameshift; Positions=191;
CC   -!- GENE_FAMILY: HOG000056452 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000089682;ENSMUST00000022806;ENSMUSP00000022806.
DR   EMBL; AF030769; - ;
DR   EMBL; AK004680; - ;
DR   EMBL; AK013244; - ;
DR   EMBL; AK015644; - ;
DR   EMBL; AK172925; - ;
DR   EMBL; AY170344; - ;
DR   EMBL; BC040369; - ;
DR   EMBL; U59746; - ;
DR   UniProtKB/Swiss-Prot; P70345; Q545Q4; Q6A093; Q8CFR2; Q8CGL4; Q9CYW5; -.
DR   EMBL; U59746; AAB09056.1; -; mRNA.
DR   EMBL; AF030769; AAB86430.1; -; mRNA.
DR   EMBL; AY170344; AAO13177.2; -; mRNA.
DR   EMBL; AK004680; BAB23468.1; -; mRNA.
DR   EMBL; AK013244; BAB28740.1; -; mRNA.
DR   EMBL; AK015644; BAB29912.1; -; mRNA.
DR   EMBL; AK172925; BAD32203.1; ALT_FRAME; mRNA.
DR   EMBL; BC040369; AAH40369.1; -; mRNA.
DR   IPI; IPI00108184; -.
DR   IPI; IPI00229366; -.
DR   RefSeq; NP_031563.1; NM_007537.1.
DR   UniGene; Mm.397611; -.
DR   UniGene; Mm.6967; -.
DR   ProteinModelPortal; P70345; -.
DR   SMR; P70345; 1-183.
DR   STRING; P70345; -.
DR   PhosphoSite; P70345; -.
DR   PRIDE; P70345; -.
DR   Ensembl; ENSMUST00000022806; ENSMUSP00000022806; ENSMUSG00000089682.
DR   Ensembl; ENSMUST00000111476; ENSMUSP00000107101; ENSMUSG00000089682.
DR   Ensembl; ENSMUST00000133397; ENSMUSP00000116385; ENSMUSG00000089682.
DR   GeneID; 12050; -.
DR   KEGG; mmu:12050; -.
DR   UCSC; uc007txe.1; mouse.
DR   UCSC; uc007txf.1; mouse.
DR   CTD; 599; -.
DR   MGI; MGI:108052; Bcl2l2.
DR   eggNOG; roNOG15154; -.
DR   GeneTree; ENSGT00530000062935; -.
DR   InParanoid; P70345; -.
DR   OMA; RMATPAS; -.
DR   OrthoDB; EOG4RBQKR; -.
DR   PhylomeDB; P70345; -.
DR   NextBio; 280343; -.
DR   ArrayExpress; P70345; -.
DR   Bgee; P70345; -.
DR   CleanEx; MM_BCL2L2; -.
DR   Genevestigator; P70345; -.
DR   GermOnline; ENSMUSG00000022194; Mus musculus.
DR   GO; GO:0005829; C:cytosol; IDA:MGI.
DR   GO; GO:0031966; C:mitochondrial membrane; IDA:MGI.
DR   GO; GO:0005515; F:protein binding; IPI:MGI.
DR   GO; GO:0006915; P:apoptosis; IDA:MGI.
DR   InterPro; IPR013280; Apop_reg_BclW.
DR   InterPro; IPR002475; Bcl2-like_apoptosis.
DR   InterPro; IPR000712; Bcl2_BH.
DR   InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR   InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR   InterPro; IPR003093; Bcl2_BH4.
DR   InterPro; IPR020731; Bcl2_BH4_motif_CS.
DR   Pfam; PF00452; Bcl-2; 1.
DR   Pfam; PF02180; BH4; 1.
DR   PRINTS; PR01865; APOPREGBCLW.
DR   PRINTS; PR01862; BCL2FAMILY.
DR   SMART; SM00337; BCL; 1.
DR   SMART; SM00265; BH4; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
DR   PROSITE; PS01080; BH1; 1.
DR   PROSITE; PS01258; BH2; 1.
DR   PROSITE; PS01260; BH4_1; 1.
DR   PROSITE; PS50063; BH4_2; 1.
DR   HOGENOMDNA; MOUSE14.PE995; -.
KW   ENSMUSG000000896825old_1320000031; ENSMUSP000000228061old_1320000031;
KW   AF030769; AK004680; AK013244; AK015644; AK172925; AY170344; BC040369;
KW   U59746;
KW   Alternative splicing; Apoptosis; Complete proteome; Membrane;
KW   Mitochondrion; Phosphoprotein; Reference proteome.
SQ   SEQUENCE   193 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MATPASTPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT
     FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG
     QVQDWMVAYL ETRLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RTVLTGAVAL
     GALVTVGAFF ASK
//

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