(data stored in ACNUC10243 zone)

HOGENOM: MOUSE15_PE1587

ID   MOUSE15_PE1587                       STANDARD;      PRT;   320 AA.
AC   MOUSE15_PE1587; P49312; P97312; Q3V269;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Heterogeneous nuclear ribonucleoprotein A1; Short=hnRNP
DE   A1;AltName: Full=HDP-1;AltName: Full=Helix-destabilizing protein;AltName:
DE   Full=Single-strand-binding protein;AltName: Full=Topoisomerase-inhibitor
DE   suppressed;AltName: Full=hnRNP core protein A1; (MOUSE15.PE1587).
GN   Name=Hnrnpa1; Synonyms=Fli-2, Hnrpa1, Tis;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE15.PE1587.
CC       Mus musculus chromosome 15 NCBIM37  sequence 1..103494974 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ROA1_MOUSE
CC   -!- FUNCTION: Involved in the packaging of pre-mRNA into hnRNP
CC       particles, transport of poly(A) mRNA from the nucleus to the
CC       cytoplasm and may modulate splice site selection.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. Identified in a
CC       mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG,
CC       HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU,
CC       HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4,
CC       PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2,
CC       YBX1 and untranslated mRNAs. Interacts with SEPT6 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localized in
CC       cytoplasmic mRNP granules containing untranslated mRNAs (By
CC       similarity). Shuttles continuously between the nucleus and the
CC       cytoplasm along with mRNA. Component of ribonucleosomes.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=P49312-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=P49312-2; Sequence=VSP_005825;
CC   -!- PTM: Sumoylated (By similarity).
CC   -!- SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
CC   -!- GENE_FAMILY: HOG000234442 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000046434;ENSMUST00000087351;ENSMUSP00000084609.
DR   EMBL; AK007802; - ;
DR   EMBL; AK088308; - ;
DR   EMBL; AK131999; - ;
DR   EMBL; AK135391; - ;
DR   EMBL; AK152684; - ;
DR   EMBL; AK161730; - ;
DR   EMBL; AK166901; - ;
DR   EMBL; AK167161; - ;
DR   EMBL; AK167810; - ;
DR   EMBL; AK167811; - ;
DR   EMBL; AK167913; - ;
DR   EMBL; AK168420; - ;
DR   EMBL; AK168531; - ;
DR   EMBL; AK169216; - ;
DR   EMBL; BC080675; - ;
DR   EMBL; BC083136; - ;
DR   EMBL; BC172047; - ;
DR   EMBL; BC172049; - ;
DR   EMBL; BC172057; - ;
DR   EMBL; BC172058; - ;
DR   EMBL; D86728; - ;
DR   EMBL; D86729; - ;
DR   EMBL; M99167; - ;
DR   UniProtKB/Swiss-Prot; P49312; P97312; Q3V269; -.
DR   EMBL; M99167; AAA37633.1; -; mRNA.
DR   EMBL; D86729; BAA13162.1; -; mRNA.
DR   EMBL; D86728; BAA13161.1; -; mRNA.
DR   EMBL; AK007802; BAB25267.1; -; mRNA.
DR   EMBL; AK088308; BAC40273.1; -; mRNA.
DR   EMBL; AK131999; BAE20929.1; -; mRNA.
DR   EMBL; AK135391; BAE22518.1; -; mRNA.
DR   EMBL; AK161730; BAE36552.1; -; mRNA.
DR   EMBL; AK166901; BAE39104.1; -; mRNA.
DR   EMBL; AK167161; BAE39302.1; -; mRNA.
DR   EMBL; AK167810; BAE39837.1; -; mRNA.
DR   EMBL; AK167913; BAE39920.1; -; mRNA.
DR   EMBL; AK168420; BAE40333.1; -; mRNA.
DR   EMBL; AK168531; BAE40409.1; -; mRNA.
DR   EMBL; BC080675; AAH80675.1; -; mRNA.
DR   EMBL; BC083136; AAH83136.1; -; mRNA.
DR   IPI; IPI00553777; -.
DR   IPI; IPI00817004; -.
DR   PIR; A44485; A44485.
DR   RefSeq; NP_034577.1; NM_010447.4.
DR   UniGene; Mm.237064; -.
DR   UniGene; Mm.432031; -.
DR   ProteinModelPortal; P49312; -.
DR   SMR; P49312; 8-190.
DR   IntAct; P49312; 5.
DR   STRING; P49312; -.
DR   PhosphoSite; P49312; -.
DR   PRIDE; P49312; -.
DR   Ensembl; ENSMUST00000087351; ENSMUSP00000084609; ENSMUSG00000046434.
DR   GeneID; 15382; -.
DR   KEGG; mmu:15382; -.
DR   UCSC; uc007xxp.1; mouse.
DR   UCSC; uc012aah.1; mouse.
DR   CTD; 3178; -.
DR   MGI; MGI:104820; Hnrnpa1.
DR   eggNOG; roNOG09634; -.
DR   OrthoDB; EOG4HQDKF; -.
DR   NextBio; 288050; -.
DR   ArrayExpress; P49312; -.
DR   Bgee; P49312; -.
DR   CleanEx; MM_HNRNPA1; -.
DR   Genevestigator; P49312; -.
DR   GermOnline; ENSMUSG00000058922; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; ISS:HGNC.
DR   GO; GO:0005654; C:nucleoplasm; ISS:HGNC.
DR   GO; GO:0005681; C:spliceosomal complex; ISS:HGNC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003697; F:single-stranded DNA binding; ISS:HGNC.
DR   GO; GO:0000380; P:alternative nuclear mRNA splicing, via spliceosome; IDA:MGI.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0051168; P:nuclear export; ISS:HGNC.
DR   GO; GO:0051170; P:nuclear import; ISS:HGNC.
DR   InterPro; IPR021662; HnRNPA1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR   InterPro; IPR000504; RRM_dom.
DR   Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
DR   Pfam; PF11627; HnRNPA1; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   PROSITE; PS50102; RRM; 2.
DR   HOGENOMDNA; MOUSE15.PE1587; -.
KW   ENSMUSG000000464345old_1320000031; ENSMUSP000000846091old_1320000031;
KW   B7ZWG9_MOUSE; Q3TFB1_MOUSE; Q3TIK8_MOUSE; Q3U7F3_MOUSE; AK007802;
KW   AK131999; AK135391; AK152684; AK161730; AK166901; AK167161; AK167810;
KW   AK167913; AK168420; AK168531; AK169216; BC080675; BC083136; BC172047;
KW   BC172057; BC172058; D86728; D86729; M99167;
KW   Acetylation; Alternative splicing; Complete proteome; Cytoplasm;
KW   Direct protein sequencing; Isopeptide bond; Methylation;
KW   mRNA processing; mRNA splicing; mRNA transport; Nucleus;
KW   Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein;
KW   RNA-binding; Spliceosome; Transport; Ubl conjugation.
SQ   SEQUENCE   320 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV
     TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH
     LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA
     LSKQEMASAS SSQRGRSGSG NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS
     GDGYNGFGND GSNFGGGGSY NDFGNYNNQS SNFGPMKGGN FGGRSSGPYG GGGQYFAKPR
     NQGGYGGSSS SSSYGSGRRF
//

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