(data stored in ACNUC3292 zone)

HOGENOM: MOUSE15_PE243

ID   MOUSE15_PE243                        STANDARD;      PRT;   901 AA.
AC   MOUSE15_PE243; Q80ZX8; Q8CCK7; Q9QZJ3; Q9QZJ4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Sperm-associated antigen 1;AltName:
DE   Full=Infertility-related sperm protein Spag-1;AltName:
DE   Full=TPR-containing protein involved in spermatogenesis; Short=TPIS;
DE   (MOUSE15.PE243).
GN   Name=Spag1; Synonyms=Tpis;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE15.PE243.
CC       Mus musculus chromosome 15 NCBIM37  sequence 1..103494974 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:SPAG1_MOUSE
CC   -!- FUNCTION: Plays a role in fertilization. Binds GTP and has GTPase
CC       activity (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q80ZX8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q80ZX8-2; Sequence=VSP_012684;
CC       Name=3;
CC         IsoId=Q80ZX8-3; Sequence=VSP_012685;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Detected in cerebellum, tongue, esophagus,
CC       forestomach, sperm and testis.
CC   -!- DEVELOPMENTAL STAGE: Expression is very low in embryonic epidermis
CC       at E13.5 and increases from E14.5 to E16.5. In young mice
CC       expression increases in the testis of 2 to 6 weeks old animals,
CC       and then remains stable.
CC   -!- MISCELLANEOUS: Antibodies against SPAG1 interfere with
CC       fertilization (By similarity).
CC   -!- SIMILARITY: Contains 8 TPR repeats.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC27944.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000293399 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000037617;ENSMUST00000047348;ENSMUSP00000047335.
DR   EMBL; AF181252; - ;
DR   EMBL; AF181253; - ;
DR   EMBL; AK032601; - ;
DR   EMBL; BC046313; - ;
DR   UniProtKB/Swiss-Prot; Q80ZX8; Q8CCK7; Q9QZJ3; Q9QZJ4; -.
DR   EMBL; AF181252; AAF06160.1; -; mRNA.
DR   EMBL; AF181253; AAF06161.1; -; mRNA.
DR   EMBL; AK032601; BAC27944.1; ALT_INIT; mRNA.
DR   EMBL; BC046313; AAH46313.1; -; mRNA.
DR   IPI; IPI00551151; -.
DR   IPI; IPI00551464; -.
DR   IPI; IPI00624261; -.
DR   PIR; JC7111; JC7111.
DR   RefSeq; NP_036161.2; NM_012031.3.
DR   UniGene; Mm.295539; -.
DR   ProteinModelPortal; Q80ZX8; -.
DR   SMR; Q80ZX8; 212-330, 430-541, 606-701.
DR   STRING; Q80ZX8; -.
DR   PhosphoSite; Q80ZX8; -.
DR   PRIDE; Q80ZX8; -.
DR   Ensembl; ENSMUST00000047348; ENSMUSP00000047335; ENSMUSG00000037617.
DR   Ensembl; ENSMUST00000171205; ENSMUSP00000132233; ENSMUSG00000037617.
DR   GeneID; 26942; -.
DR   KEGG; mmu:26942; -.
DR   UCSC; uc007vmn.1; mouse.
DR   UCSC; uc007vmp.1; mouse.
DR   CTD; 6674; -.
DR   MGI; MGI:1349387; Spag1.
DR   eggNOG; roNOG10630; -.
DR   GeneTree; ENSGT00600000084276; -.
DR   InParanoid; Q80ZX8; -.
DR   OMA; EDYKEKT; -.
DR   OrthoDB; EOG4FFD17; -.
DR   PhylomeDB; Q80ZX8; -.
DR   NextBio; 304865; -.
DR   ArrayExpress; Q80ZX8; -.
DR   Bgee; Q80ZX8; -.
DR   Genevestigator; Q80ZX8; -.
DR   GermOnline; ENSMUSG00000037617; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR   InterPro; IPR001440; TPR-1.
DR   InterPro; IPR013026; TPR-contain.
DR   InterPro; IPR011990; TPR-like_helical.
DR   InterPro; IPR019734; TPR_repeat.
DR   Gene3D; G3DSA:1.25.40.10; TPR-like_helical; 3.
DR   Pfam; PF00515; TPR_1; 4.
DR   SMART; SM00028; TPR; 8.
DR   PROSITE; PS50005; TPR; 6.
DR   PROSITE; PS50293; TPR_REGION; 4.
DR   HOGENOMDNA; MOUSE15.PE243; -.
KW   ENSMUSG000000376175old_1320000031; ENSMUSP000000473351old_1320000031;
KW   AF181252; AF181253; AK032601; BC046313;
KW   Alternative splicing; Complete proteome; Cytoplasm; Fertilization;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Repeat; TPR repeat.
SQ   SEQUENCE   901 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTAKAKDCPS LWGFGTTKTF KIPIEHLDFK YIENCSDVKH LEKILYVLRS GEEGYYPELT
     EFCEKCLTNL APKSRALRKD KPAETASSFS AEEWEKIDSD LKSWVSEIKR EENTCHFHDP
     ENHPGVEDPL PPVRGSTCCP HSGKETYSKS KTAKKRIPRD YAEWDKFDVE KECSKIDEDY
     KEKTVINNKA HLSKIETKIE TAGLTEKEKS FLANREKGKG NEAFYSGDYE EAVMYYTRSL
     SALPTAIAYN NRAQAEIKLQ RWSSALEDCE KALELDPGNV KALLRRATTY KHQNKLQEAV
     DDLRKVLQVE PDNDLAKKTL SEVERDLKNS EPVSELQTKG KRMVIEEVEN SGDEGGKGSA
     DEREDGGSDE AAMGNIQKKL MVRRSEGGRR SRRGRTPGPR AEQQGGLRET ATASTGDSHY
     PEEPRAADNP SGLKRRGNEL FRGGQFAEAA AQYSVAIAQL EPTGSANADE LSILYSNRAA
     CYLKEGNCRD CIQDCNRALE LHPFSVKPLL RRAMAYETLE QYRNAYVDYK TVLQIDCGIQ
     LASDSANRIA RILTELDGSK WRERLPPIPA VPTSEPLRVW LPAAETPDQD PCPNNCMPSI
     TDEKMFQALK EEGNQLVKDK NYKDAISKYN ECLKINSKAC AIYTNRALCY LKLGQFEEAK
     LDCEQALQID GENVKASHRL ALAQKGLENC RESGVDPSQV LLSPDSSEAA RHLDTKNDTA
     PPSKGRERRR IQVQEVDGSS DEEPERPAEA SATSAPARDG VEDGGSAEPA EKLDVSKPTN
     AYEFGQVLST ISARKDEEAC AHLLAITAPK DLPLLLSNKL EGDTFLLLIQ SLKSHLVAKD
     PSLVYEHLLY LSKAERFKTM LTLINKGQKE QMAQLFDGLS DTQSDGLTAE DVQALRRQYE
     L
//

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