(data stored in ACNUC1122 zone)

HOGENOM: MOUSE16_PE134

ID   MOUSE16_PE134                        STANDARD;      PRT;   1155 AA.
AC   MOUSE16_PE134; P79621; O46787; O78036; O78109; Q31115; Q9TPP1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=MHC class II transactivator; Short=CIITA; (MOUSE16.PE134).
GN   Name=Ciita; Synonyms=C2ta, Mhc2ta;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE16.PE134.
CC       Mus musculus chromosome 16 NCBIM37  sequence 1..98319150 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:C2TA_MOUSE
CC   -!- FUNCTION: Essential for transcriptional activity of the HLA class
CC       II promoter; activation is via the proximal promoter. No DNA
CC       binding of in vitro translated CIITA was detected. May act in a
CC       coactivator-like fashion through protein-protein interactions by
CC       contacting factors binding to the proximal MHC class II promoter,
CC       to elements of the transcription machinery, or both. Alternatively
CC       it may activate HLA class II transcription by modifying proteins
CC       that bind to the MHC class II promoter (By similarity).
CC   -!- SUBUNIT: Interacts with ZXDA and ZXDC (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=I;
CC         IsoId=P79621-1; Sequence=Displayed;
CC       Name=2; Synonyms=III;
CC         IsoId=P79621-2; Sequence=VSP_007214, VSP_007215;
CC       Name=3; Synonyms=IV;
CC         IsoId=P79621-3; Sequence=VSP_007216;
CC   -!- TISSUE SPECIFICITY: Isoform 1 is expressed at very high levels in
CC       dendritic cells, at very low levels in spleen and thymus and is
CC       not detected in other tissues. Isoform 2 is detected at high
CC       levels in spleen and tonsil as well as in a number of B-lymphocyte
CC       cell lines, and at very low levels in dendritic cells.
CC   -!- INDUCTION: By interferon gamma.
CC   -!- SIMILARITY: Contains 4 LRR (leucine-rich) repeats.
CC   -!- SIMILARITY: Contains 1 NACHT domain.
CC   -!- GENE_FAMILY: HOG000107439 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000022504;ENSMUST00000074090;ENSMUSP00000073732.
DR   EMBL; AF000006; - ;
DR   EMBL; AF000007; - ;
DR   EMBL; AF042158; - ;
DR   EMBL; AF042159; - ;
DR   EMBL; AF100709; - ;
DR   EMBL; AF100710; - ;
DR   EMBL; AK138822; - ;
DR   EMBL; AK143956; - ;
DR   EMBL; AK155311; - ;
DR   EMBL; U46562; - ;
DR   EMBL; U60653; - ;
DR   UniProtKB/Swiss-Prot; P79621; O46787; O78036; O78109; Q31115; Q9TPP1; -.
DR   EMBL; AF000006; AAB92364.2; -; Genomic_DNA.
DR   EMBL; AF000007; AAB92365.1; -; Genomic_DNA.
DR   EMBL; AF042158; AAC34366.1; -; mRNA.
DR   EMBL; AF042159; AAC34367.1; -; mRNA.
DR   EMBL; AF100709; AAF06838.1; -; mRNA.
DR   EMBL; AF100710; AAF06839.1; -; mRNA.
DR   EMBL; U60653; AAB48859.1; -; mRNA.
DR   EMBL; U46562; AAB05004.1; -; mRNA.
DR   IPI; IPI00108982; -.
DR   IPI; IPI00115417; -.
DR   IPI; IPI00742270; -.
DR   RefSeq; NP_031601.1; NM_007575.2.
DR   UniGene; Mm.249560; -.
DR   ProteinModelPortal; P79621; -.
DR   SMR; P79621; 968-1137.
DR   STRING; P79621; -.
DR   PhosphoSite; P79621; -.
DR   PRIDE; P79621; -.
DR   Ensembl; ENSMUST00000023147; ENSMUSP00000023147; ENSMUSG00000022504.
DR   Ensembl; ENSMUST00000074090; ENSMUSP00000073732; ENSMUSG00000022504.
DR   GeneID; 12265; -.
DR   KEGG; mmu:12265; -.
DR   UCSC; uc007ydr.1; mouse.
DR   UCSC; uc007yds.1; mouse.
DR   CTD; 4261; -.
DR   MGI; MGI:108445; Ciita.
DR   eggNOG; roNOG04049; -.
DR   InParanoid; P79621; -.
DR   OMA; LYNNCIC; -.
DR   OrthoDB; EOG48PMJD; -.
DR   PhylomeDB; P79621; -.
DR   ArrayExpress; P79621; -.
DR   Bgee; P79621; -.
DR   CleanEx; MM_CIITA; -.
DR   Genevestigator; P79621; -.
DR   GermOnline; ENSMUSG00000022504; Mus musculus.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0032403; F:protein complex binding; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:MGI.
DR   GO; GO:0034341; P:response to interferon-gamma; IDA:MGI.
DR   GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   InterPro; IPR008095; MHC_II_transact.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   PRINTS; PR01719; MHCIIACTVATR.
DR   PROSITE; PS50837; NACHT; 1.
DR   HOGENOMDNA; MOUSE16.PE134; -.
KW   ENSMUSG000000225045old_1320000031; ENSMUSP000000737321old_1320000031;
KW   Q3U2F8_MOUSE; Q3UNW8_MOUSE; Q3UU40_MOUSE; AF000006; AF000007; AF042158;
KW   AF100709; AF100710; AK138822; AK143956; AK155311; U46562; U60653;
KW   Activator; Alternative splicing; ATP-binding; Complete proteome;
KW   Leucine-rich repeat; Nucleotide-binding; Nucleus; Reference proteome;
KW   Repeat; Transcription; Transcription regulation.
SQ   SEQUENCE   1155 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNHFQAILAQ VQTLLSSQKP RQVRALLDGL LEEELLSREY HCALLHEPDG DALARKISLT
     LLEKGDLDLT FLSWVCNSLQ APTVERGTSY RDHGDHSLCA TMDLGSPEGS YLELLNSDAD
     PLHLYHLYDQ MDLAGEEEIE LSSEPDTDTI NCDQFSKLLQ DMELDEETRE AYANIAELDQ
     YVFQDTQLEG LSKDLFIEHI GAEEGFGENI EIPVEAGQKP QKRRFPEEHA MDSKHRKLVP
     TSRTSLNYLD LPTGHIQIFT TLPQGLWQIS GAGTGLSSVL IYHGEMPQVN QVLPSSSLSI
     PSLPESPDRP GSTSPFTPSA ADLPSMPEPA LTSRVNETED TSPSPCQEGP ESSIKLPKWP
     EAVERFQHSL QDKYKALPQS PRGPLVAVEL VRARLERGSN KSQERELATP DWTERQLAHG
     GLAEVLQVVS DCRRPGETQV VAVLGKAGQG KSHWARTVSH TWACGQLLQY DFVFYVPCHC
     LDRPGDTYHL RDLLCPPSLQ PLAMDDEVLD YIVRQPDRVL LILDAFEELE AQDGLLHGPC
     GSLSPEPCSL RGLLAGIFQR KLLRGCTLLL TARPRGRLAQ SLSKADAIFE VPSFSTKQAK
     TYMRHYFENS GTAGNQDKAL GLLEGQPLLC SYSHSPVVCR AVCQLSKALL EQGTEAQLPC
     TLTGLYVSLL GPAAQNSPPG ALVELAKLAW ELGRRHQSTL QETRFSSVEV KTWAVTQGLM
     QQTLETTEAQ LAFSSFLLQC FLGAVWLAQC NEIKDKELPQ YLALTPRKKR PYDNWLEGVP
     RFLAGLVFQP RAHCLGALVE PAVAAVADRK QKVLTRYLKR LKLGTLRAGR LLELLHCAHE
     TQQPGIWEHV AHQLPGHLSF LGTRLTPPDV YVLGRALETA SQDFSLDLRQ TGVEPSGLGN
     LVGLSCVTSF RASLSDTMAL WESLQQQGEA QLLQAAEEKF TIEPFKAKSP KDVEDLDRLV
     QTQRLRNPSE DAAKDLPAIR DLKKLEFALG PILGPQAFPT LAKILPAFSS LQHLDLDSLS
     ENKIGDKGVS KLSATFPQLK ALETLNLSQN NITDVGACKL AEALPALAKS LLRLSLYNNC
     ICDKGAKSLA QVLPDMVSLR VMDVQFNKFT AAGAQQLASS LQKCPQVETL AMWTPTIPFG
     VQEHLQQLDA RISLR
//

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