(data stored in ACNUC15468 zone)

HOGENOM: MOUSE16_PE550

ID   MOUSE16_PE550                        STANDARD;      PRT;   908 AA.
AC   MOUSE16_PE550; Q9R0A1; Q0VBC2; Q9WUJ9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Chloride channel protein 2; Short=ClC-2; (MOUSE16.PE550).
GN   Name=Clcn2; Synonyms=Clc2;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE16.PE550.
CC       Mus musculus chromosome 16 NCBIM37  sequence 1..98319150 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CLCN2_MOUSE
CC   -!- FUNCTION: Voltage-gated chloride channel. Chloride channels have
CC       several functions including the regulation of cell volume;
CC       membrane potential stabilization, signal transduction and
CC       transepithelial transport.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- MISCELLANEOUS: The CLC channel family contains both chloride
CC       channels and proton-coupled anion transporters that exchange
CC       chloride or another anion for protons. The absence of conserved
CC       gating glutamate residues is typical for family members that
CC       function as channels (By similarity).
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       ClC-2/CLCN2 subfamily.
CC   -!- SIMILARITY: Contains 2 CBS domains.
CC   -!- GENE_FAMILY: HOG000231297 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000022843;ENSMUST00000007207;ENSMUSP00000007207.
DR   EMBL; AC087898; - ;
DR   EMBL; AF097415; - ;
DR   EMBL; AF139724; - ;
DR   EMBL; AK155104; - ;
DR   EMBL; AK171231; - ;
DR   EMBL; BC120699; - ;
DR   EMBL; BC137625; - ;
DR   EMBL; CT010490; - ;
DR   UniProtKB/Swiss-Prot; Q9R0A1; Q0VBC2; Q9WUJ9; -.
DR   EMBL; AF097415; AAD50604.1; -; mRNA.
DR   EMBL; AF139724; AAD26466.1; -; mRNA.
DR   EMBL; CT010490; CAP19214.1; -; Genomic_DNA.
DR   EMBL; AC087898; CAP19214.1; JOINED; Genomic_DNA.
DR   EMBL; BC120699; AAI20700.1; -; mRNA.
DR   EMBL; BC137625; AAI37626.1; -; mRNA.
DR   IPI; IPI00127238; -.
DR   RefSeq; NP_034030.2; NM_009900.2.
DR   UniGene; Mm.177761; -.
DR   ProteinModelPortal; Q9R0A1; -.
DR   STRING; Q9R0A1; -.
DR   PhosphoSite; Q9R0A1; -.
DR   PRIDE; Q9R0A1; -.
DR   Ensembl; ENSMUST00000007207; ENSMUSP00000007207; ENSMUSG00000022843.
DR   GeneID; 12724; -.
DR   KEGG; mmu:12724; -.
DR   CTD; 1181; -.
DR   MGI; MGI:105061; Clcn2.
DR   eggNOG; roNOG10523; -.
DR   GeneTree; ENSGT00550000074179; -.
DR   InParanoid; Q9R0A1; -.
DR   OrthoDB; EOG4G7BXQ; -.
DR   NextBio; 282012; -.
DR   ArrayExpress; Q9R0A1; -.
DR   Bgee; Q9R0A1; -.
DR   CleanEx; MM_CLCN2; -.
DR   Genevestigator; Q9R0A1; -.
DR   GermOnline; ENSMUSG00000022843; Mus musculus.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IMP:MGI.
DR   GO; GO:0060689; P:cell differentiation involved in salivary gland development; IMP:MGI.
DR   GO; GO:0060041; P:retina development in camera-type eye; IMP:MGI.
DR   InterPro; IPR002244; Cl-channel-2.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR000644; Cysta_beta_synth_core.
DR   Gene3D; G3DSA:1.10.3080.10; Cl-channel_core; 1.
DR   PANTHER; PTHR11689; Cl-channel_volt; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01113; CLCHANNEL2.
DR   SMART; SM00116; CBS; 1.
DR   SUPFAM; SSF81340; Cl-channel_core; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   HOGENOMDNA; MOUSE16.PE550; -.
KW   ENSMUSG000000228435old_1320000031; ENSMUSP000000072071old_1320000031;
KW   Q0VBC2_MOUSE; Q3TBI1_MOUSE; AC087898; AF097415; AF139724; AK155104;
KW   BC120699; BC137625; CT010490;
KW   CBS domain; Chloride; Chloride channel; Complete proteome;
KW   Ion transport; Ionic channel; Membrane; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
SQ   SEQUENCE   908 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAATAAAAA AAAAGEGMEP RALQYEQTLM YGRYTQELGA FAKEEAARIR LGGPEPWKGS
     PSARATPELL EYGQSRCARC RICSVRCHKF LVSRVGEDWI FLVLLGLLMA LVSWAMDYAI
     AVCLQAQQWM SRGLNTNILL QYLAWVTYPV VLITFSAGFT QILAPQAVGS GIPEMKTILR
     GVVLKEYLTL KTFVAKVIGL TCALGSGMPL GKEGPFVHIA SMCAALLSKF LSLFGGIYEH
     ESRNTEMLAA ACAVGVGCCF AAPIGGVLFS IEVTSTFFAV RNYWRGFFAA TFSAFIFRVL
     AVWNRDEETI TALFKTRFRL DFPFDLQELP AFAVIGIASG FGGALFVYLN RKIVQVMRKQ
     KTINRFLMRK RLLFPALVTL LISTLTFPPG FGQFMAGQLS QKETLVTLFD NRTWVRQGLV
     EDLELPSTSQ AWSPPRANVF LTLVIFILMK FWMSALATTI PVPCGAFMPV FVIGAAFGRL
     VGESMAAWFP DGIHTDSSTY RIVPGGYAVV GAAALAGAVT HTVSTAVIVF ELTGQIAHIL
     PVMIAVILAN AVAQSLQPSL YDSIIRIKKL PYLPELGWGR HQQYRVRVED IMVRDVPHVA
     LSCTFRDLRL ALHRTKGRML ALVESPESMI LLGSIERSQV VALLGAQLSP ARRRQHMQKL
     RKAQLSPPSD QESPPSSETS IRFQVNTEDS GFSGAHGQTH KPLKPALKRG PSNSTSLQEG
     TTGNMESAGI ALRSLFCGSP PLEATSELEK SESCDKRKLK RVRISLASDS DPEAEMSPEE
     ILEWEEQQLD EPVNFSDCKI DPAPFQLVER TSLHKTHTIF SLLGVDHAYV TSIGRLIGIV
     TLKELRKAIE GSVTAQGVKV RPPLASFRDS ATSSSDTETT EVHALWGPRS RHGLPREGTP
     SDSDDKCQ
//

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