(data stored in ACNUC5448 zone)

HOGENOM: MOUSE16_PE827

ID   MOUSE16_PE827                        STANDARD;      PRT;   1403 AA.
AC   MOUSE16_PE827; B1B1A7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   SubName: Full=Kalirin, RhoGEF kinase;SubName: Full=Uncharacterized
DE   protein;Flags: Fragment; (MOUSE16.PE827).
GN   Name=Kalrn; ORFNames=RP23-363L9.1-002;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE16.PE827.
CC       Mus musculus chromosome 16 NCBIM37  sequence 1..98319150 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:B1B1A7_MOUSE
CC   -!- SIMILARITY: Contains 1 CRAL-TRIO domain.
CC   -!- SIMILARITY: Contains 1 DH (DBL-homology) domain.
CC   -!- GENE_FAMILY: HOG000044462 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000061751;ENSMUST00000151491;ENSMUSP00000123416.
DR   EMBL; AC154524; - ;
DR   EMBL; AC154588; - ;
DR   EMBL; CT010573; - ;
DR   UniProtKB/Swiss-Prot; B1B1A7; -.
DR   EMBL; AC155257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC165079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CT010573; CAM18310.1; -; Genomic_DNA.
DR   EMBL; AC154524; CAM18310.1; JOINED; Genomic_DNA.
DR   EMBL; AC154588; CAM18310.1; JOINED; Genomic_DNA.
DR   IPI; IPI00776083; -.
DR   UniGene; Mm.353103; -.
DR   UniGene; Mm.450612; -.
DR   UniGene; Mm.82274; -.
DR   ProteinModelPortal; B1B1A7; -.
DR   SMR; B1B1A7; 176-403, 519-751, 1026-1329.
DR   STRING; B1B1A7; -.
DR   Ensembl; ENSMUST00000151491; ENSMUSP00000123416; ENSMUSG00000061751.
DR   MGI; MGI:2685385; Kalrn.
DR   GeneTree; ENSGT00560000076675; -.
DR   Bgee; B1B1A7; -.
DR   Genevestigator; B1B1A7; -.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   InterPro; IPR001251; CRAL-bd_TRIO_C.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH_type.
DR   InterPro; IPR001849; Pleckstrin_homology.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   Gene3D; G3DSA:3.40.525.10; CRAL_bd_TRIO_C; 1.
DR   Gene3D; G3DSA:2.30.29.30; PH_type; 1.
DR   Gene3D; G3DSA:1.20.900.10; RhoGEF; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00435; Spectrin; 3.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SMART; SM00150; SPEC; 4.
DR   SUPFAM; SSF52087; CRAL_TRIO_C; 1.
DR   SUPFAM; SSF48065; DH-domain; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   HOGENOMDNA; MOUSE16.PE827; -.
KW   ENSMUSG000000617515old_1320000031; ENSMUSP000001234161old_1320000031;
KW   AC154524; AC154588; CT010573;
KW   Complete proteome; Kinase; Reference proteome; Repeat.
SQ   SEQUENCE   1403 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     YLRLLRLLDR GSFRNDGLKA SDVLPILKEK VAFVSGGRDK RGGPILTFPA RSNHDRIRQE
     DLRKLVTYLA SVPSEDVCKR GFTVIIDMRG SKWDLIKPLL KTLQEAFPAE IHVALIIKPD
     NFWQKQKTNF GSSKFIFETS MVSVEGLTKL VDPSQLTEEF DGSLDYNHEE WIELRLSLEE
     FFNSAVHLLS RLEDLQEMLA RKEFPVDVEG SRRLIDEHTQ LKKKVLKAPV EELDREGQRL
     LQCIRCSDGF SGRNCIPGSA DFQSLVPKIT SLLDKLHSTR QHLHQMWHVR KLKLDQCFQL
     RLFEQDAEKM FDWISHNKEL FLQSHTEIGV SYQHALDLQT QHNHFAMNSM NAYVNINRIM
     SVASRLSEAG HYASQQIKQI STQLDQEWKS FAAALDERST ILAMSAVFHQ KAEQFLSGVD
     AWCKMCSEGG LPSEMQDLEL AIHHHQSLYE QVTQAYTEVS QDGKALLDVL QRPLSPGNSE
     SLTATANYSK AVHQVLDVVQ MEELFHERKI KLDIFLQLRI FEQYTIEVTA ELDAWNEDLL
     RQMNDFNTED LTLAEQRLQR HTERKLAMNN MTFEVIQQGQ DLHQYIMEVQ ASGIELICEK
     DLDLAAQVQE LLEFLHEKQH ELELNAEQTH KRLEQCLQLR HLQAEVKQVL GWIRNGESML
     NASLVNASSL SEAEQLQREH EQFQLAIESL FHATSLQKTH QSALQVQQKA EALLQAGHYD
     ADAIRECAEK VALHWQQLML KMEDRLKLVN ASVAFYKTSE QVCSVLESLE QEYRRDEDWC
     GGRDKLGPAA EMDHVIPLLS KHLEQKEAFL KACTLARRNA EVFLKYIHRN NVSMPSVASH
     TRGPEQQVKA ILSELLQREN RVLHFWTLKK RRLDQCQQYV VFERSAKQAL DWIQETGEYY
     LSTHTSTGET TEETQELLKE YGEFRVPAKQ TKEKVKLLIQ LADSFVEKGH IHATEIRKWV
     TTVDKHYRDF SLRMGKYRYS LEKALGVNTE DNKDLELDII PASLSDREVK LRDANHEINE
     EKRKSARKKE FIMAELLQTE KAYVRDLHEC LETYLWEMTS GVEEIPPGIL NKEHIIFGNI
     QEIYDFHNNI FLKELEKYEQ LPEDVGHCFV TWADKFQMYV TYCKNKPDSN QLILEHAGTF
     FDEIQQRHGL ANSISSYLIK PVQRVTKYQL LLKELLTCCE EGKGELKDGL EVMLSVPKKA
     NDAMHVSMLE GFDENLDVQG ELILQDAFQV WDPKSLIRKG RERHLFLFEI SLVFSKEIKD
     SSGHTKYVYK NKLLTSELGV TEHVEGDPCK FALWSGRTPS SDNKTVLKAS NIETKQEWIK
     NIREVIQERI IHLKGALKEP IQLPKTPAKL RNNSKRDGVE DGDSQGDGSS QPDTISIASR
     TSQNTVESDK DGNLVPRWHL GPG
//

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