(data stored in ACNUC5448 zone)

HOGENOM: MOUSE16_PE833

ID   MOUSE16_PE833                        STANDARD;      PRT;   1422 AA.
AC   MOUSE16_PE833; B1B1A7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=Kalirin, RhoGEF kinase;SubName: Full=Uncharacterized
DE   protein;Flags: Fragment; (MOUSE16.PE833).
GN   Name=Kalrn; ORFNames=RP23-363L9.1-002;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE16.PE833.
CC       Mus musculus chromosome 16 NCBIM37  sequence 1..98319150 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:B1B1A7_MOUSE
CC   -!- SIMILARITY: Contains 1 CRAL-TRIO domain.
CC   -!- SIMILARITY: Contains 1 DH (DBL-homology) domain.
CC   -!- GENE_FAMILY: HOG000044462 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000061751;ENSMUST00000114957;ENSMUSP00000110607.
DR   EMBL; AC154524; - ;
DR   EMBL; AC154588; - ;
DR   EMBL; BC058850; - ;
DR   EMBL; CT010573; - ;
DR   UniProtKB/Swiss-Prot; B1B1A7; -.
DR   EMBL; AC155257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC165079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CT010573; CAM18310.1; -; Genomic_DNA.
DR   EMBL; AC154524; CAM18310.1; JOINED; Genomic_DNA.
DR   EMBL; AC154588; CAM18310.1; JOINED; Genomic_DNA.
DR   IPI; IPI00776083; -.
DR   UniGene; Mm.353103; -.
DR   UniGene; Mm.450612; -.
DR   UniGene; Mm.82274; -.
DR   ProteinModelPortal; B1B1A7; -.
DR   SMR; B1B1A7; 176-403, 519-751, 1026-1329.
DR   STRING; B1B1A7; -.
DR   Ensembl; ENSMUST00000151491; ENSMUSP00000123416; ENSMUSG00000061751.
DR   MGI; MGI:2685385; Kalrn.
DR   GeneTree; ENSGT00560000076675; -.
DR   Bgee; B1B1A7; -.
DR   Genevestigator; B1B1A7; -.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   InterPro; IPR001251; CRAL-bd_TRIO_C.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH_type.
DR   InterPro; IPR001849; Pleckstrin_homology.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   Gene3D; G3DSA:3.40.525.10; CRAL_bd_TRIO_C; 1.
DR   Gene3D; G3DSA:2.30.29.30; PH_type; 1.
DR   Gene3D; G3DSA:1.20.900.10; RhoGEF; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00435; Spectrin; 3.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SMART; SM00150; SPEC; 4.
DR   SUPFAM; SSF52087; CRAL_TRIO_C; 1.
DR   SUPFAM; SSF48065; DH-domain; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   HOGENOMDNA; MOUSE16.PE833; -.
KW   ENSMUSG000000617515old_1320000031; ENSMUSP000001106071old_1320000031;
KW   Q6PD97_MOUSE; AC154524; AC154588; BC058850; CT010573;
KW   Complete proteome; Kinase; Reference proteome; Repeat.
SQ   SEQUENCE   1422 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTDRFWDQWY LWYLRLLRLL DRGSFRNDGL KASDVLPILK EKVAFVSGGR DKRGGPILTF
     PARSNHDRIR QEDLRKLVTY LASVPSEDVC KRGFTVIIDM RGSKWDLIKP LLKTLQEAFP
     AEIHVALIIK PDNFWQKQKT NFGSSKFIFE TSMVSVEGLT KLVDPSQLTE EFDGSLDYNH
     EEWIELRLSL EEFFNSAVHL LSRLEDLQEM LARKEFPVDV EGSRRLIDEH TQLKKKVLKA
     PVEELDREGQ RLLQCIRCSD GFSGRNCIPG SADFQSLVPK ITSLLDKLHS TRQHLHQMWH
     VRKLKLDQCF QLRLFEQDAE KMFDWISHNK ELFLQSHTEI GVSYQHALDL QTQHNHFAMN
     SMNAYVNINR IMSVASRLSE AGHYASQQIK QISTQLDQEW KSFAAALDER STILAMSAVF
     HQKAEQFLSG VDAWCKMCSE GGLPSEMQDL ELAIHHHQSL YEQVTQAYTE VSQDGKALLD
     VLQRPLSPGN SESLTATANY SKAVHQVLDV VQMEELFHER KIKLDIFLQL RIFEQYTIEV
     TAELDAWNED LLRQMNDFNT EDLTLAEQRL QRHTERKLAM NNMTFEVIQQ GQDLHQYIME
     VQASGIELIC EKDLDLAAQV QELLEFLHEK QHELELNAEQ THKRLEQCLQ LRHLQAEVKQ
     VLGWIRNGES MLNASLVNAS SLSEAEQLQR EHEQFQLAIE SLFHATSLQK THQSALQVQQ
     KAEALLQAGH YDADAIRECA EKVALHWQQL MLKMEDRLKL VNASVAFYKT SEQVCSVLES
     LEQEYRRDED WCGGRDKLGP AAEMDHVIPL LSKHLEQKEA FLKACTLARR NAEVFLKYIH
     RNNVSMPSVA SHTRGPEQQV KAILSELLQR ENRVLHFWTL KKRRLDQCQQ YVVFERSAKQ
     ALDWIQETGE YYLSTHTSTG ETTEETQELL KEYGEFRVPA KQTKEKVKLL IQLADSFVEK
     GHIHATEIRK WVTTVDKHYR DFSLRMGKYR YSLEKALGVN TEDNKDLELD IIPASLSDRE
     VKLRDANHEI NEEKRKSARK KEFIMAELLQ TEKAYVRDLH ECLETYLWEM TSGVEEIPPG
     ILNKEHIIFG NIQEIYDFHN NIFLKELEKY EQLPEDVGHC FVTWADKFQM YVTYCKNKPD
     SNQLILEHAG TFFDEIQQRH GLANSISSYL IKPVQRVTKY QLLLKELLTC CEEGKGELKD
     GLEVMLSVPK KANDAMHVSM LEGFDENLDV QGELILQDAF QVWDPKSLIR KGRERHLFLF
     EISLVFSKEI KDSSGHTKYV YKNKLLTSEL GVTEHVEGDP CKFALWSGRT PSSDNKTVLK
     ASNIETKQEW IKNIREVIQE RIIHLKGALK EPIQLPKTPA KLRNNSKRDG VEDGDSQGDG
     SSQPDTISIA SRTSQNTVES DKDGNLVPRW HLGPGDPFST YV
//

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