(data stored in ACNUC21562 zone)

HOGENOM: MOUSE17_PE148

ID   MOUSE17_PE148                        STANDARD;      PRT;   324 AA.
AC   MOUSE17_PE148; P30554; O35944; Q8BHI8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Proto-oncogene Mas; (MOUSE17.PE148).
GN   Name=Mas1; Synonyms=Mas, Mas-1;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE17.PE148.
CC       Mus musculus chromosome 17 NCBIM37  sequence 1..95272651 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MAS_MOUSE
CC   -!- FUNCTION: Acts specifically as a functional antagonist of AGTR1
CC       (angiotensin-2 type 1 receptor), although it up-regulates AGTR1
CC       receptor levels. Positive regulation of AGTR1 levels occurs
CC       through activation of the G-proteins GNA11 and GNAQ, and
CC       stimulation of the protein kinase C signaling cascade. The
CC       antagonist effect on AGTR1 function is probably due to AGTR1 being
CC       physically altered by MAS1 (By similarity). Receptor for
CC       angiotensin 1-7.
CC   -!- SUBUNIT: Interacts with AGTR1 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC   -!- GENE_FAMILY: HOG000015412 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000068037;ENSMUST00000089015;ENSMUSP00000086409.
DR   EMBL; AK015036; - ;
DR   EMBL; AK030261; - ;
DR   EMBL; AK030265; - ;
DR   EMBL; BC120790; - ;
DR   EMBL; BC125537; - ;
DR   EMBL; BC144900; - ;
DR   EMBL; CH466619; - ;
DR   EMBL; U96273; - ;
DR   EMBL; X67735; - ;
DR   UniProtKB/Swiss-Prot; P30554; O35944; Q8BHI8; -.
DR   EMBL; X67735; CAA47964.1; -; Genomic_DNA.
DR   EMBL; AK030261; BAC26865.1; -; mRNA.
DR   EMBL; AK030265; BAC26868.1; -; mRNA.
DR   EMBL; U96273; AAB69120.1; -; mRNA.
DR   IPI; IPI00131264; -.
DR   PIR; S51001; S51001.
DR   RefSeq; NP_032578.2; NM_008552.4.
DR   UniGene; Mm.425994; -.
DR   ProteinModelPortal; P30554; -.
DR   SMR; P30554; 117-147.
DR   STRING; P30554; -.
DR   PhosphoSite; P30554; -.
DR   PRIDE; P30554; -.
DR   Ensembl; ENSMUST00000089015; ENSMUSP00000086409; ENSMUSG00000068037.
DR   Ensembl; ENSMUST00000161747; ENSMUSP00000123902; ENSMUSG00000068037.
DR   Ensembl; ENSMUST00000162333; ENSMUSP00000125108; ENSMUSG00000068037.
DR   Ensembl; ENSMUST00000165020; ENSMUSP00000132300; ENSMUSG00000068037.
DR   Ensembl; ENSMUST00000167152; ENSMUSP00000131341; ENSMUSG00000068037.
DR   GeneID; 17171; -.
DR   KEGG; mmu:17171; -.
DR   CTD; 4142; -.
DR   MGI; MGI:96918; Mas1.
DR   eggNOG; roNOG14620; -.
DR   InParanoid; P30554; -.
DR   OMA; DEMQPRR; -.
DR   OrthoDB; EOG4SJ5F8; -.
DR   PhylomeDB; P30554; -.
DR   NextBio; 462260; -.
DR   ArrayExpress; P30554; -.
DR   Bgee; P30554; -.
DR   CleanEx; MM_MAS1; -.
DR   Genevestigator; P30554; -.
DR   GermOnline; ENSMUSG00000068037; Mus musculus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001595; F:angiotensin receptor activity; IMP:UniProtKB.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   InterPro; IPR000820; Mas_TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00533; MASONCOGENE.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   HOGENOMDNA; MOUSE17.PE148; -.
KW   ENSMUSG000000680375old_1320000031; ENSMUSP000000864091old_1320000031;
KW   Q0VB49_MOUSE; Q9D5Q2_MOUSE; AK015036; AK030261; AK030265; BC120790;
KW   BC144900; CH466619; U96273; X67735;
KW   Cell membrane; Complete proteome; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Proto-oncogene; Receptor; Reference proteome;
KW   Transducer; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   324 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDQSNMTSLA EEKAMNTSSR NASLGSSHPP IPIVHWVIMS ISPLGFVENG ILLWFLCFRM
     RRNPFTVYIT HLSIADISLL FCIFILSIDY ALDYELSSGH HYTIVTLSVT FLFGYNTGLY
     LLTAISVERC LSVLYPIWYR CHRPKHQSAF VCALLWALSC LVTTMEYVMC IDSGEESHSR
     SDCRAVIIFI AILSFLVFTP LMLVSSTILV VKIRKNTWAS HSSKLYIVIM VTIIIFLIFA
     MPMRVLYLLY YEYWSAFGNL HNISLLFSTI NSSANPFIYF FVGSSKKKRF RESLKVVLTR
     AFKDEMQPRR QEGNGNTVSI ETVV
//

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