(data stored in ACNUC5448 zone)

HOGENOM: MOUSE18_PE291

ID   MOUSE18_PE291                        STANDARD;      PRT;   2113 AA.
AC   MOUSE18_PE291; Q99MZ6; B9EHR5; Q571N7; Q8R0U3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Myosin-VIIb; (MOUSE18.PE291).
GN   Name=Myo7b;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE18.PE291.
CC       Mus musculus chromosome 18 NCBIM37  sequence 1..90772031 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MYO7B_MOUSE
CC   -!- FUNCTION: Myosins are actin-based motor molecules with ATPase
CC       activity. Their highly divergent tails are presumed to bind to
CC       membranous compartments, which would be moved relative to actin
CC       filaments. May be have a role in the apical membranes of
CC       transporting epithelia.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane (Probable).
CC   -!- TISSUE SPECIFICITY: Expressed primarily in kidney and intestine.
CC       Detected in proximal tubule cells of the kidney and enterocytes of
CC       the intestine, specifically the distal tips of apical microvilli
CC       on these transporting epithelial cells (at protein level).
CC   -!- DEVELOPMENTAL STAGE: Detected in intestinal enterocytes at
CC       embyonic day 17.
CC   -!- SIMILARITY: Contains 2 FERM domains.
CC   -!- SIMILARITY: Contains 6 IQ domains.
CC   -!- SIMILARITY: Contains 1 myosin head-like domain.
CC   -!- SIMILARITY: Contains 3 MyTH4 domains.
CC   -!- SIMILARITY: Contains 2 SH3 domains.
CC   -!- GENE_FAMILY: HOG000007836 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000024388;ENSMUST00000134663;ENSMUSP00000118046.
DR   EMBL; AF242411; - ;
DR   EMBL; AK220152; - ;
DR   EMBL; BC026416; - ;
DR   EMBL; BC138338; - ;
DR   EMBL; BC138341; - ;
DR   UniProtKB/Swiss-Prot; Q99MZ6; B9EHR5; Q571N7; Q8R0U3; -.
DR   EMBL; AF242411; AAK28339.1; -; mRNA.
DR   EMBL; BC138338; AAI38339.1; -; mRNA.
DR   EMBL; BC138341; AAI38342.1; -; mRNA.
DR   EMBL; BC026416; AAH26416.1; -; mRNA.
DR   EMBL; AK220152; BAD90338.1; -; mRNA.
DR   IPI; IPI00118238; -.
DR   RefSeq; NP_115770.2; NM_032394.3.
DR   UniGene; Mm.440013; -.
DR   HSSP; P08799; 1MND.
DR   ProteinModelPortal; Q99MZ6; -.
DR   PhosphoSite; Q99MZ6; -.
DR   PRIDE; Q99MZ6; -.
DR   Ensembl; ENSMUST00000134663; ENSMUSP00000118046; ENSMUSG00000024388.
DR   GeneID; 17922; -.
DR   KEGG; mmu:17922; -.
DR   CTD; 4648; -.
DR   MGI; MGI:107709; Myo7b.
DR   eggNOG; roNOG10422; -.
DR   GeneTree; ENSGT00590000082740; -.
DR   InParanoid; Q99MZ6; -.
DR   NextBio; 292785; -.
DR   ArrayExpress; Q99MZ6; -.
DR   Genevestigator; Q99MZ6; -.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003774; F:motor activity; IEA:InterPro.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR000857; MyTH4_dom.
DR   InterPro; IPR011993; PH_type.
DR   InterPro; IPR001452; SH3_domain.
DR   Gene3D; G3DSA:1.20.80.10; ACBP; 2.
DR   Gene3D; G3DSA:2.30.29.30; PH_type; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF00612; IQ; 4.
DR   Pfam; PF00063; Myosin_head; 1.
DR   Pfam; PF00784; MyTH4; 2.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00295; B41; 2.
DR   SMART; SM00015; IQ; 4.
DR   SMART; SM00242; MYSc; 1.
DR   SMART; SM00139; MyTH4; 2.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF47031; FERM_3-hlx; 2.
DR   SUPFAM; SSF50044; SH3; 1.
DR   PROSITE; PS00660; FERM_1; FALSE_NEG.
DR   PROSITE; PS00661; FERM_2; FALSE_NEG.
DR   PROSITE; PS50057; FERM_3; 2.
DR   PROSITE; PS50096; IQ; 4.
DR   PROSITE; PS51016; MYTH4; 2.
DR   PROSITE; PS50002; SH3; 1.
DR   HOGENOMDNA; MOUSE18.PE291; -.
KW   ENSMUSG000000243885old_1320000031; ENSMUSP000001180461old_1320000031;
KW   AF242411; AK220152; BC026416; BC138338; BC138341;
KW   Actin-binding; ATP-binding; Cell membrane; Complete proteome;
KW   Membrane; Motor protein; Myosin; Nucleotide-binding;
KW   Reference proteome; Repeat; SH3 domain.
SQ   SEQUENCE   2113 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSVFRLGDHV WLDPPSSSKT GVAIGGIVKE TKLGKTLIED DEGKEHWVHA EDLSTLRPMH
     PNSAQGVDDM IRLGDLNEAG VVHNLLIRYQ QHKIYTYTGS ILVAVNPFQM LPLYTLEQVQ
     IYYSRHMGEL PPHIFAIANS CYFNMKKNKR DQCCIISGES GAGKTETTKL ILQFLATVSG
     QHSWIEQQVL EANPILEAFG NAKTIRNDNS SRFGKYIDIH FNSSGVIEGA SIEHFLLEKS
     RVCRQAPEER NYHIFYCMLM GMSPEEKQML SLGMPSEYHY LTMGSCTSSE GLSDAKDYAH
     VRSAMKILQF SDSENWDISK LLAAILHLGN VGFMAAVFEN LDSSDVMETP AFPLAMKLLE
     VQHQALRDCL IKHTIPVLGE FVSRPVNIAQ ATDRRDAFVK GIYGRLFQWI VKKINAAIFT
     PQAQDPQNVR RAIGLLDIFG FENFQNNSFE QLCINFANEH LQQFFVKHVF TMEQEEYLSE
     NITWNYIHYT DNQPILDMLA LKPMSIISLL DEESRFPQGT DVTMLQKLNS IHANNKSFLS
     PRSIHDTRFG IAHFAGDVYY QAEGFLEKNR DVLSTDILIL IHSSKNKFLK EIFNVDSSQT
     KLGHGTICQV KAGSQLFKSS DSIKRPVTLA SQFKQSLDQL MRILTNCQPY FVRCIKPNEY
     KKPLLFDREL CIQQLRYSGM METVHIRKSG FPIRYTFDEF SQRFRVLLPS PERMQFQNKP
     RQMTLHIADL CLGTDKDWKV GKTKIFLKDH QDTVLEIRRS QALDGAAIRI QRVLRGHKYR
     KEFLRQRRAA VTLQAGWRGY SQRKNFKLIL VGFERLQAIA RSHLLMRQFQ AMRQRIVQLQ
     ARCRGYLVRQ QVQAKRRAVV IIQAHARGMV VRKSYWQQKS TGPQVILAKE PKAQVAVHER
     KRKSIYDTVT DTAMVEKVFG FLPAMIGGQE GPAPTRFEDL EVKTQKLHEV DLDTVPMMAM
     PEEEVDSLAE YTFPKFAVTY FQKSASHTHI QKPLRYPLLY HENDTDHSAA LDVWIIILRF
     MGDLPEPVVY GRNSLTGSSV MRQIHDKLGK DSVTQHNRSS QVASQLNFGE EAFKFDGPIS
     DRPMSNLEKV HFIVGYAIMR PGLRDEIYCQ ICKQLSENYK TSSRARGWIL LSLCLGCFPP
     SERFMKYLLN FISQGPPSYG PFCAERLQRT FANGVRAEPP TWLELQAVKS KKHIPIQVIL
     ATGRSLTISV DSASTSREIC QHVAQKQGLR DNLGFSLQVA VYDKFWSLGS GCDHLMDAVA
     QCEQLARERG ESQRQAPWRI YFRKEFFTPW HDSQEDPVST ELIYHQVLRG VWSGEYNFEK
     EEELVELLAR HCYVQLGATV KSNAVQELLP SCVPSKLYRT KSPEKWASLV TAAHAKAQYT
     QSKATPLAVR EQTVEAARLL WPLLFSRLFE VTTLSGPRLP KTQLVLAINW KGMYFLDQKE
     RTLLGLSFAE VMGLVANRDA PGGKKLLLAT LQEEYEFVSP SSVAIAEMVA LFLGGLKERS
     VFAMALQDRR ATDDITLLPF KKGDLLILTK KQGLLASENW ALGQNDRTGK TGLVPTACLY
     TIPSVTKPST QLLSLLAMSP EKRKLAAQEV RALEPPLEDQ LTESPYTLEE FSYQFFRAPE
     KETISRAAMP MARSRGHLWA YSPEPLRQPL LKSVHDKAKL RDAACQIFLA ILKYTGDYPS
     RQSWHSLELT DQMFSLALQD PALQDELYCQ ILKQLTHNSI RFSEERAWQL LWLCTGLFPP
     GKTLLPHAQK FIDSRKKKPL ALDCSRRLHR VLRVGPRKQP PHDVEVKAAE QNVSKLHHEV
     YLPNDTSKSM EVGSSSRVRD LCEGIGTRLQ LASWDGCSLF IKITDKVISL KEGDFFFDSL
     RQVSDWVKKN RPQKEGASVT LPYQVFFMRK LWLNVTPGKD VNADTILHYH QELPKYLRGF
     HKCSREDAIH LGGLICKIQF GSDSSQLASV SKVLKELVPQ NLTRLMSSEE WKKSLLLECD
     KNKRKTVAEA KVEFLKYMYR WPTFGSAFFE VKQTSEPSYP DILLIAINRH GLLLIHPKTK
     ELLNTYPFTK ISSWSSGNTY FHMALGSLGQ GSRLLCETSL GYKMDDLLTS YVQQLLNTVN
     KQRGFRAPAP ANP
//

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