(data stored in ACNUC9435 zone)

HOGENOM: MOUSE18_PE350

ID   MOUSE18_PE350                        STANDARD;      PRT;   533 AA.
AC   MOUSE18_PE350; P08046; Q61777;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Early growth response protein 1; Short=EGR-1;AltName:
DE   Full=Nerve growth factor-induced protein A; Short=NGFI-A;AltName:
DE   Full=Transcription factor Zif268;AltName: Full=Zinc finger protein
DE   Krox-24; (MOUSE18.PE350).
GN   Name=Egr1; Synonyms=Egr-1, Krox-24;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE18.PE350.
CC       Mus musculus chromosome 18 NCBIM37  sequence 1..90772031 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:EGR1_MOUSE
CC   -!- FUNCTION: Transcriptional regulator. Recognizes and binds to the
CC       DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the
CC       transcription of target genes whose products are required for
CC       mitogenesis and differentiation.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- INDUCTION: By growth factors.
CC   -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
CC   -!- GENE_FAMILY: HOG000036856 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000038418;ENSMUST00000064795;ENSMUSP00000069616.
DR   EMBL; AK037837; - ;
DR   EMBL; AK040925; - ;
DR   EMBL; AK133630; - ;
DR   EMBL; AK145198; - ;
DR   EMBL; AK146322; - ;
DR   EMBL; BC138613; - ;
DR   EMBL; BC138615; - ;
DR   EMBL; M19643; - ;
DR   EMBL; M20157; - ;
DR   EMBL; M22326; - ;
DR   EMBL; M28844; - ;
DR   EMBL; M28845; - ;
DR   EMBL; M38174; - ;
DR   UniProtKB/Swiss-Prot; P08046; Q61777; -.
DR   EMBL; M20157; AAA37544.1; -; mRNA.
DR   EMBL; M22326; AAA40416.1; -; mRNA.
DR   EMBL; M28845; AAB00468.1; -; Genomic_DNA.
DR   EMBL; M28844; AAB00468.1; JOINED; Genomic_DNA.
DR   EMBL; M19643; AAA39382.1; -; mRNA.
DR   IPI; IPI00128530; -.
DR   PIR; JS0304; JS0304.
DR   RefSeq; NP_031939.1; NM_007913.5.
DR   UniGene; Mm.181959; -.
DR   PDB; 1A1F; X-ray; 2.10 A; A=333-421.
DR   PDB; 1A1G; X-ray; 1.90 A; A=333-421.
DR   PDB; 1A1H; X-ray; 1.60 A; A=333-421.
DR   PDB; 1A1I; X-ray; 1.60 A; A=333-421.
DR   PDB; 1A1J; X-ray; 2.00 A; A=333-421.
DR   PDB; 1A1K; X-ray; 1.90 A; A=333-421.
DR   PDB; 1A1L; X-ray; 2.30 A; A=333-421.
DR   PDB; 1AAY; X-ray; 1.60 A; A=333-421.
DR   PDB; 1F2I; X-ray; 2.35 A; G/H/I/J/K/L=334-389.
DR   PDB; 1G2D; X-ray; 2.20 A; C/F=333-421.
DR   PDB; 1G2F; X-ray; 2.00 A; C/F=333-421.
DR   PDB; 1JK1; X-ray; 1.90 A; A=333-421.
DR   PDB; 1JK2; X-ray; 1.65 A; A=333-421.
DR   PDB; 1LLM; X-ray; 1.50 A; C/D=364-412.
DR   PDB; 1P47; X-ray; 2.20 A; A/B=333-419.
DR   PDB; 1ZAA; X-ray; 2.10 A; C=332-418.
DR   PDBsum; 1A1F; -.
DR   PDBsum; 1A1G; -.
DR   PDBsum; 1A1H; -.
DR   PDBsum; 1A1I; -.
DR   PDBsum; 1A1J; -.
DR   PDBsum; 1A1K; -.
DR   PDBsum; 1A1L; -.
DR   PDBsum; 1AAY; -.
DR   PDBsum; 1F2I; -.
DR   PDBsum; 1G2D; -.
DR   PDBsum; 1G2F; -.
DR   PDBsum; 1JK1; -.
DR   PDBsum; 1JK2; -.
DR   PDBsum; 1LLM; -.
DR   PDBsum; 1P47; -.
DR   PDBsum; 1ZAA; -.
DR   ProteinModelPortal; P08046; -.
DR   SMR; P08046; 334-533.
DR   STRING; P08046; -.
DR   PhosphoSite; P08046; -.
DR   PRIDE; P08046; -.
DR   Ensembl; ENSMUST00000064795; ENSMUSP00000069616; ENSMUSG00000038418.
DR   Ensembl; ENSMUST00000165033; ENSMUSP00000126931; ENSMUSG00000038418.
DR   GeneID; 13653; -.
DR   KEGG; mmu:13653; -.
DR   CTD; 1958; -.
DR   MGI; MGI:95295; Egr1.
DR   eggNOG; maNOG15075; -.
DR   InParanoid; P08046; -.
DR   OMA; SCAVPSN; -.
DR   OrthoDB; EOG4BP1BT; -.
DR   PhylomeDB; P08046; -.
DR   NextBio; 284384; -.
DR   ArrayExpress; P08046; -.
DR   Bgee; P08046; -.
DR   CleanEx; MM_EGR1; -.
DR   Genevestigator; P08046; -.
DR   GermOnline; ENSMUSG00000038418; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0000982; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factoDR   GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
DR   GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0030509; P:BMP signaling pathway; IDA:MGI.
DR   GO; GO:0071480; P:cellular response to gamma radiation; IMP:BHF-UCL.
DR   GO; GO:0071504; P:cellular response to heparin; ISS:UniProtKB.
DR   GO; GO:0071506; P:cellular response to mycophenolic acid; ISS:UniProtKB.
DR   GO; GO:0071445; P:cellular response to protein stimulus; IDA:MGI.
DR   GO; GO:0072110; P:glomerular mesangial cell proliferation; ISS:UniProtKB.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
DR   GO; GO:0072303; P:positive regulation of glomerular metanephric mesangial cell proliferation; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
DR   GO; GO:0009749; P:response to glucose stimulus; IDA:UniProtKB.
DR   GO; GO:0032868; P:response to insulin stimulus; IDA:UniProtKB.
DR   GO; GO:0030217; P:T cell differentiation; IMP:MGI.
DR   InterPro; IPR021839; DUF3432.
DR   InterPro; IPR021849; DUF3446.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 3.
DR   Pfam; PF11914; DUF3432; 1.
DR   Pfam; PF11928; DUF3446; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
DR   HOGENOMDNA; MOUSE18.PE350; -.
KW   ENSMUSG000000384185old_1320000031; ENSMUSP000000696161old_1320000031;
KW   Q3UM09_MOUSE; Q3UZU7_MOUSE; Q544D6_MOUSE; Q6LDK7_MOUSE; Q8CAT6_MOUSE;
KW   AK040925; AK133630; AK145198; AK146322; BC138613; BC138615; M19643;
KW   M22326; M28844; M28845; M38174;
KW   3D-structure; Activator; Complete proteome; DNA-binding;
KW   Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   533 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML LSNGAPQFLG AAGTPEGSGG
     NSSSSTSSGG GGGGGSNSGS SAFNPQGEPS EQPYEHLTTE SFSDIALNNE KAMVETSYPS
     QTTRLPPITY TGRFSLEPAP NSGNTLWPEP LFSLVSGLVS MTNPPTSSSS APSPAASSSS
     SASQSPPLSC AVPSNDSSPI YSAAPTFPTP NTDIFPEPQS QAFPGSAGTA LQYPPPAYPA
     TKGGFQVPMI PDYLFPQQQG DLSLGTPDQK PFQGLENRTQ QPSLTPLSTI KAFATQSGSQ
     DLKALNTTYQ SQLIKPSRMR KYPNRPSKTP PHERPYACPV ESCDRRFSRS DELTRHIRIH
     TGQKPFQCRI CMRNFSRSDH LTTHIRTHTG EKPFACDICG RKFARSDERK RHTKIHLRQK
     DKKADKSVVA SPAASSLSSY PSPVATSYPS PATTSFPSPV PTSYSSPGSS TYPSPAHSGF
     PSPSVATTFA SVPPAFPTQV SSFPSAGVSS SFSTSTGLSD MTATFSPRTI EIC
//

If you have problems or comments...

PBIL Back to PBIL home page