(data stored in ACNUC15324 zone)

HOGENOM: MOUSE1_PE1585

ID   MOUSE1_PE1585                        STANDARD;      PRT;   181 AA.
AC   MOUSE1_PE1585; Q925S4; Q925J3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Interleukin-24; Short=IL-24;AltName: Full=IL-4-induced
DE   secreted protein;AltName: Full=Melanoma differentiation-associated gene 7
DE   protein; Short=MDA-7;AltName: Full=Th2-specific cytokine FISP;Flags:
DE   Precursor; (MOUSE1.PE1585).
GN   Name=Il24; Synonyms=Mda7;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE1.PE1585.
CC       Mus musculus chromosome 1 NCBIM37  sequence 1..197195432 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:IL24_MOUSE
CC   -!- FUNCTION: Has antiproliferative properties on melanoma cells and
CC       may contribute to terminal cell differentiation (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- TISSUE SPECIFICITY: Selectively expressed by Th2 cells.
CC   -!- INDUCTION: By IL-4.
CC   -!- SIMILARITY: Belongs to the IL-10 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK52470.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000113033 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000026420;ENSMUST00000027679;ENSMUSP00000027679.
DR   EMBL; AF235006; - ;
DR   EMBL; AF333251; - ;
DR   UniProtKB/Swiss-Prot; Q925S4; Q925J3; -.
DR   EMBL; AF235006; AAK52590.1; -; mRNA.
DR   EMBL; AF333251; AAK52470.1; ALT_INIT; mRNA.
DR   IPI; IPI00126941; -.
DR   RefSeq; NP_444325.2; NM_053095.2.
DR   UniGene; Mm.196691; -.
DR   ProteinModelPortal; Q925S4; -.
DR   SMR; Q925S4; 30-181.
DR   STRING; Q925S4; -.
DR   PRIDE; Q925S4; -.
DR   GeneID; 93672; -.
DR   KEGG; mmu:93672; -.
DR   UCSC; uc007cmo.1; mouse.
DR   CTD; 11009; -.
DR   MGI; MGI:2135548; Il24.
DR   eggNOG; roNOG16189; -.
DR   GeneTree; ENSGT00410000025637; -.
DR   InParanoid; Q925S4; -.
DR   OrthoDB; EOG4ZPDW8; -.
DR   ArrayExpress; Q925S4; -.
DR   Bgee; Q925S4; -.
DR   CleanEx; MM_IL24; -.
DR   Genevestigator; Q925S4; -.
DR   GermOnline; ENSMUSG00000026420; Mus musculus.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR020443; Interleukin-10/19/20/24.
DR   InterPro; IPR020423; Interleukin-10_CS.
DR   InterPro; IPR020444; Interleukin-24.
DR   Gene3D; G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.
DR   PANTHER; PTHR11585; Interleukin_10; 1.
DR   Pfam; PF00726; IL10; 1.
DR   PRINTS; PR01937; INTRLEUKIN24.
DR   SMART; SM00188; IL10; 1.
DR   SUPFAM; SSF47266; 4_helix_cytokine; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
DR   HOGENOMDNA; MOUSE1.PE1585; -.
KW   ENSMUSG000000264205old_1320000031; ENSMUSP000000276791old_1320000031;
KW   AF235006; AF333251;
KW   Apoptosis; Complete proteome; Cytokine; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
SQ   SEQUENCE   181 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSWGLQILPC LSLILLLWNQ VPGLEGQEFR FGSCQVTGVV LPELWEAFWT VKNTVQTQDD
     ITSIRLLKPQ VLRNVSGAES CYLAHSLLKF YLNTVFKNYH SKIAKFKVLR SFSTLANNFI
     VIMSQLQPSK DNSMLPISES AHQRFLLFRR AFKQLDTEVA LVKAFGEVDI LLTWMQKFYH
     L
//

If you have problems or comments...

PBIL Back to PBIL home page