(data stored in ACNUC15324 zone)

HOGENOM: MOUSE1_PE1588

ID   MOUSE1_PE1588                        STANDARD;      PRT;   176 AA.
AC   MOUSE1_PE1588; Q8CJ70;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Interleukin-19; Short=IL-19;Flags: Precursor;
DE   (MOUSE1.PE1588).
GN   Name=Il19;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE1.PE1588.
CC       Mus musculus chromosome 1 NCBIM37  sequence 1..197195432 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:IL19_MOUSE
CC   -!- FUNCTION: May play some important roles in inflammatory responses.
CC       Up-regulates IL-6 and TNF-alpha and induces apoptosis.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-10 family.
CC   -!- GENE_FAMILY: HOG000113033 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000016524;ENSMUST00000016668;ENSMUSP00000016668.
DR   EMBL; AF453945; - ;
DR   EMBL; BC115793; - ;
DR   EMBL; CH466520; - ;
DR   UniProtKB/Swiss-Prot; Q8CJ70; -.
DR   EMBL; AF453945; AAN40905.1; -; mRNA.
DR   IPI; IPI00229944; -.
DR   RefSeq; NP_001009940.1; NM_001009940.1.
DR   UniGene; Mm.131480; -.
DR   ProteinModelPortal; Q8CJ70; -.
DR   SMR; Q8CJ70; 23-170.
DR   STRING; Q8CJ70; -.
DR   PRIDE; Q8CJ70; -.
DR   Ensembl; ENSMUST00000016668; ENSMUSP00000016668; ENSMUSG00000016524.
DR   Ensembl; ENSMUST00000112465; ENSMUSP00000108084; ENSMUSG00000016524.
DR   GeneID; 329244; -.
DR   KEGG; mmu:329244; -.
DR   NMPDR; fig|10090.3.peg.1011; -.
DR   CTD; 29949; -.
DR   MGI; MGI:1890472; Il19.
DR   GeneTree; ENSGT00410000025637; -.
DR   InParanoid; Q8CJ70; -.
DR   OMA; IQAKDTF; -.
DR   OrthoDB; EOG4XWG07; -.
DR   PhylomeDB; Q8CJ70; -.
DR   NextBio; 398640; -.
DR   ArrayExpress; Q8CJ70; -.
DR   Bgee; Q8CJ70; -.
DR   CleanEx; MM_IL19; -.
DR   Genevestigator; Q8CJ70; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0006917; P:induction of apoptosis; IDA:MGI.
DR   GO; GO:0042226; P:interleukin-6 biosynthetic process; IDA:MGI.
DR   GO; GO:0072593; P:reactive oxygen species metabolic process; IDA:MGI.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR020443; Interleukin-10/19/20/24.
DR   InterPro; IPR020423; Interleukin-10_CS.
DR   InterPro; IPR020421; Interleukin-19.
DR   Gene3D; G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1.
DR   PANTHER; PTHR11585; Interleukin_10; 1.
DR   Pfam; PF00726; IL10; 1.
DR   PRINTS; PR01934; INTRLEUKIN19.
DR   SMART; SM00188; IL10; 1.
DR   SUPFAM; SSF47266; 4_helix_cytokine; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
DR   HOGENOMDNA; MOUSE1.PE1588; -.
KW   ENSMUSG000000165245old_1320000031; ENSMUSP000000166681old_1320000031;
KW   Q14BK1_MOUSE; AF453945; BC115793; CH466520;
KW   Apoptosis; Complete proteome; Cytokine; Disulfide bond; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
SQ   SEQUENCE   176 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKTQCASTWL LGMTLILCSV HIYSLRRCLI SVDMRLIEKS FHEIKRAMQT KDTFKNVTIL
     SLENLRSIKP GDVCCMTNNL LTFYRDRVFQ DHQERSLEVL RRISSIANSF LCVQKSLERC
     QVHRQCNCSQ EATNATRIIH DNYNQLEVSS AALKSLGELN ILLAWIDRNH LETPAA
//

If you have problems or comments...

PBIL Back to PBIL home page