(data stored in ACNUC17492 zone)

HOGENOM: MOUSE1_PE1875

ID   MOUSE1_PE1875                        STANDARD;      PRT;   211 AA.
AC   MOUSE1_PE1875; O08849; Q544S7; Q91WX1; Q9JL24;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 2; Short=RGS2;
DE   (MOUSE1.PE1875).
GN   Name=Rgs2;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE1.PE1875.
CC       Mus musculus chromosome 1 NCBIM37  sequence 1..197195432 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS2_MOUSE
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. May play a role in leukemogenesis.
CC       Binds EIF2B5 and blocks its activity, thereby inhibiting the
CC       translation of mRNA into protein.
CC   -!- SUBUNIT: Interacts with EIF2B5 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane (By similarity). Cytoplasm (By
CC       similarity). Nucleus, nucleolus (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed in a wide variety of tissues.
CC   -!- PTM: Phosphorylated by protein kinase C (By similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000026360;ENSMUST00000127206;ENSMUSP00000115558.
DR   EMBL; AF215668; - ;
DR   EMBL; AF432916; - ;
DR   EMBL; AK031603; - ;
DR   EMBL; AK077922; - ;
DR   EMBL; AK162276; - ;
DR   EMBL; AL713991; - ;
DR   EMBL; BC023001; - ;
DR   EMBL; CH466520; - ;
DR   EMBL; U67187; - ;
DR   UniProtKB/Swiss-Prot; O08849; Q544S7; Q91WX1; Q9JL24; -.
DR   EMBL; U67187; AAB50617.1; -; mRNA.
DR   EMBL; AF215668; AAF34625.1; -; mRNA.
DR   EMBL; AF432916; AAL28114.1; -; mRNA.
DR   EMBL; AK031603; BAC27471.1; -; mRNA.
DR   EMBL; AK077922; BAC37065.1; -; mRNA.
DR   EMBL; AK162276; BAE36830.1; -; mRNA.
DR   EMBL; BC023001; AAH23001.1; -; mRNA.
DR   IPI; IPI00309304; -.
DR   RefSeq; NP_033087.2; NM_009061.4.
DR   UniGene; Mm.28262; -.
DR   ProteinModelPortal; O08849; -.
DR   SMR; O08849; 34-203.
DR   MINT; MINT-4953705; -.
DR   STRING; O08849; -.
DR   PhosphoSite; O08849; -.
DR   PRIDE; O08849; -.
DR   Ensembl; ENSMUST00000127206; ENSMUSP00000115558; ENSMUSG00000026360.
DR   GeneID; 19735; -.
DR   KEGG; mmu:19735; -.
DR   CTD; 5997; -.
DR   MGI; MGI:1098271; Rgs2.
DR   eggNOG; roNOG12367; -.
DR   GeneTree; ENSGT00600000084096; -.
DR   InParanoid; O08849; -.
DR   OMA; AKKIYTD; -.
DR   OrthoDB; EOG4ZGPD8; -.
DR   PhylomeDB; O08849; -.
DR   NextBio; 297172; -.
DR   ArrayExpress; O08849; -.
DR   Bgee; O08849; -.
DR   CleanEx; MM_RGS2; -.
DR   Genevestigator; O08849; -.
DR   GermOnline; ENSMUSG00000026360; Mus musculus.
DR   GO; GO:0005829; C:cytosol; IMP:BHF-UCL.
DR   GO; GO:0009898; C:internal side of plasma membrane; IDA:BHF-UCL.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; TAS:MGI.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0050873; P:brown fat cell differentiation; IDA:MGI.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signaling pathway; TAS:MGI.
DR   GO; GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IMP:BHF-UCL.
DR   GO; GO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; IMP:BHF-UCL.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IMP:BHF-UCL.
DR   GO; GO:0010519; P:negative regulation of phospholipase activity; IMP:BHF-UCL.
DR   GO; GO:0060452; P:positive regulation of cardiac muscle contraction; IMP:BHF-UCL.
DR   GO; GO:0071877; P:regulation of adrenergic receptor signaling pathway; IMP:BHF-UCL.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0055119; P:relaxation of cardiac muscle; IMP:BHF-UCL.
DR   GO; GO:0007283; P:spermatogenesis; IEP:BHF-UCL.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; MOUSE1.PE1875; -.
KW   ENSMUSG000000263605old_1320000031; ENSMUSP000001155581old_1320000031;
KW   B1AVP8_MOUSE; AF215668; AF432916; AK031603; AK077922; AK162276; AL713991;
KW   CH466520; U67187;
KW   Cell cycle; Cell membrane; Complete proteome; Cytoplasm; Membrane;
KW   Nucleus; Phosphoprotein; Reference proteome;
KW   Signal transduction inhibitor; Translation regulation.
SQ   SEQUENCE   211 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ NSSAPGKPKT
     GKKSKQQTFI KPSPEEAQLW AEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK
     KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKSLIAQ NIQEATSGCF TTAQKRVYSL
     MENNSYPRFL ESEFYQDLCK KPQITTEPHA T
//

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