(data stored in ACNUC17492 zone)

HOGENOM: MOUSE1_PE1878

ID   MOUSE1_PE1878                        STANDARD;      PRT;   196 AA.
AC   MOUSE1_PE1878; Q9JL25; Q3TBD1; Q3TC18; Q3TD56; Q3U477;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 1; Short=RGS1;
DE   (MOUSE1.PE1878).
GN   Name=Rgs1;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE1.PE1878.
CC       Mus musculus chromosome 1 NCBIM37  sequence 1..197195432 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS1_MOUSE
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9JL25-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9JL25-2; Sequence=VSP_036732;
CC   -!- PTM: Could be phosphorylated. Might be functionally regulated by
CC       protein kinase(s) (By similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF34624.1; Type=Erroneous initiation;
CC       Sequence=AAH28634.1; Type=Erroneous initiation;
CC       Sequence=BAE23749.1; Type=Erroneous initiation;
CC       Sequence=BAE32557.1; Type=Erroneous initiation;
CC       Sequence=BAE41748.1; Type=Erroneous initiation;
CC       Sequence=BAE42139.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000026358;ENSMUST00000027604;ENSMUSP00000027604.
DR   EMBL; AF215667; - ;
DR   EMBL; AK138688; - ;
DR   EMBL; AK154394; - ;
DR   EMBL; AK170366; - ;
DR   EMBL; AK170957; - ;
DR   EMBL; AK171306; - ;
DR   EMBL; BC028634; - ;
DR   UniProtKB/Swiss-Prot; Q9JL25; Q3TBD1; Q3TC18; Q3TD56; Q3U477; -.
DR   EMBL; AK138688; BAE23749.1; ALT_INIT; mRNA.
DR   EMBL; AK154394; BAE32557.1; ALT_INIT; mRNA.
DR   EMBL; AK170366; BAE41748.1; ALT_INIT; mRNA.
DR   EMBL; AK170957; BAE42139.1; ALT_INIT; mRNA.
DR   EMBL; AK171306; BAE42382.1; -; mRNA.
DR   EMBL; AF215667; AAF34624.1; ALT_INIT; mRNA.
DR   EMBL; BC028634; AAH28634.1; ALT_INIT; mRNA.
DR   IPI; IPI00123372; -.
DR   IPI; IPI00923657; -.
DR   RefSeq; NP_056626.2; NM_015811.2.
DR   UniGene; Mm.103701; -.
DR   ProteinModelPortal; Q9JL25; -.
DR   SMR; Q9JL25; 71-204.
DR   IntAct; Q9JL25; 3.
DR   STRING; Q9JL25; -.
DR   PRIDE; Q9JL25; -.
DR   Ensembl; ENSMUST00000172388; ENSMUSP00000130339; ENSMUSG00000026358.
DR   GeneID; 50778; -.
DR   KEGG; mmu:50778; -.
DR   UCSC; uc007cxj.2; mouse.
DR   UCSC; uc007cxk.1; mouse.
DR   CTD; 5996; -.
DR   MGI; MGI:1354694; Rgs1.
DR   eggNOG; roNOG13361; -.
DR   GeneTree; ENSGT00600000084096; -.
DR   InParanoid; Q9JL25; -.
DR   OrthoDB; EOG42822Z; -.
DR   NextBio; 307717; -.
DR   ArrayExpress; Q9JL25; -.
DR   Bgee; Q9JL25; -.
DR   CleanEx; MM_RGS1; -.
DR   Genevestigator; Q9JL25; -.
DR   GermOnline; ENSMUSG00000026358; Mus musculus.
DR   GO; GO:0005886; C:plasma membrane; TAS:MGI.
DR   GO; GO:0005096; F:GTPase activator activity; TAS:MGI.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signaling pathway; TAS:MGI.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 2.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; MOUSE1.PE1878; -.
KW   ENSMUSG000000263585old_1320000031; ENSMUSP000000276041old_1320000031;
KW   AF215667; AK138688; AK154394; AK170366; AK170957; AK171306; BC028634;
KW   Alternative splicing; Complete proteome; Phosphoprotein;
KW   Reference proteome; Signal transduction inhibitor.
SQ   SEQUENCE   196 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPGMFFSASP KDSKEHSHSL LDDKKQKKRP KTFGMDVKTY LRSMIPHLES GMKSAKSKDI
     LSAEEVMQWS QSLEKLLANQ TGQNVFGRFL KSEFSEENIE FWLACEDYKK TETDLLHNKA
     ENIYKAFVHS DAVKQINIDF HTRESTAKKI KTPTPTSFDE AQKVIYSLME KDSYPRFLKS
     NIYLNLLNDL QANTLK
//

If you have problems or comments...

PBIL Back to PBIL home page