(data stored in ACNUC17492 zone)

HOGENOM: MOUSE1_PE1879

ID   MOUSE1_PE1879                        STANDARD;      PRT;   235 AA.
AC   MOUSE1_PE1879; Q99PG4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 18; Short=RGS18;
DE   (MOUSE1.PE1879).
GN   Name=Rgs18;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE1.PE1879.
CC       Mus musculus chromosome 1 NCBIM37  sequence 1..197195432 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS18_MOUSE
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-
CC       2, G(i) alpha-3 and G(q) alpha.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Expressed in bone marrow, spleen, fetal liver
CC       and lung. At very low levels expressed in heart.
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000026357;ENSMUST00000027603;ENSMUSP00000027603.
DR   EMBL; AB042807; - ;
DR   EMBL; AF302685; - ;
DR   EMBL; AK036407; - ;
DR   EMBL; BC099387; - ;
DR   EMBL; BC132544; - ;
DR   EMBL; BC132546; - ;
DR   EMBL; CH466520; - ;
DR   UniProtKB/Swiss-Prot; Q99PG4; -.
DR   EMBL; AF302685; AAG53657.1; -; mRNA.
DR   EMBL; AB042807; BAB60723.1; -; mRNA.
DR   IPI; IPI00121020; -.
DR   RefSeq; NP_075019.1; NM_022881.4.
DR   UniGene; Mm.253927; -.
DR   ProteinModelPortal; Q99PG4; -.
DR   SMR; Q99PG4; 75-206.
DR   STRING; Q99PG4; -.
DR   PhosphoSite; Q99PG4; -.
DR   PRIDE; Q99PG4; -.
DR   Ensembl; ENSMUST00000027603; ENSMUSP00000027603; ENSMUSG00000026357.
DR   GeneID; 64214; -.
DR   KEGG; mmu:64214; -.
DR   CTD; 64407; -.
DR   MGI; MGI:1927498; Rgs18.
DR   GeneTree; ENSGT00600000084388; -.
DR   InParanoid; Q99PG4; -.
DR   OMA; EVNLDFH; -.
DR   OrthoDB; EOG42BX9H; -.
DR   PhylomeDB; Q99PG4; -.
DR   NextBio; 319964; -.
DR   ArrayExpress; Q99PG4; -.
DR   Bgee; Q99PG4; -.
DR   CleanEx; MM_RGS18; -.
DR   Genevestigator; Q99PG4; -.
DR   GermOnline; ENSMUSG00000026357; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005096; F:GTPase activator activity; IDA:MGI.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signaling pathway; IPI:MGI.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IDA:MGI.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; MOUSE1.PE1879; -.
KW   ENSMUSG000000263575old_1320000031; ENSMUSP000000276031old_1320000031;
KW   Q544K2_MOUSE; AB042807; AF302685; AK036407; BC099387; BC132544; BC132546;
KW   CH466520;
KW   Complete proteome; Cytoplasm; Reference proteome;
KW   Signal transduction inhibitor.
SQ   SEQUENCE   235 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDMSLVFFSQ LNMCESKEKT FFKLMHGSGK EETSIEAKIR AKEKRNRLSL LLQRPDFHGE
     TQASRSALLA KETRVSPEEA VKWAESFDKL LSHRDGVDAF TRFLKTEFSE ENIEFWVACE
     DFKKCKEPQQ IILKAKAIYE KFIQNDAPKE VNIDFHTKEV IAKSIAQPTL HSFDTAQSRV
     YQLMEHDSYK RFLKSETYLH LIEGRPQRPT NLRRRSRSFT YNDFQDVKSD VAIWL
//

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