(data stored in ACNUC17492 zone)

HOGENOM: MOUSE1_PE1953

ID   MOUSE1_PE1953                        STANDARD;      PRT;   180 AA.
AC   MOUSE1_PE1953; Q8BXT1; Q505F2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 8; Short=RGS8;
DE   (MOUSE1.PE1953).
GN   Name=Rgs8;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE1.PE1953.
CC       Mus musculus chromosome 1 NCBIM37  sequence 1..197195432 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS8_MOUSE
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Preferentially binds to G(o)-alpha
CC       and G(i)-alpha-3 (By similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000042671;ENSMUST00000041776;ENSMUSP00000045715.
DR   EMBL; AC154140; - ;
DR   EMBL; AK044337; - ;
DR   EMBL; AK142301; - ;
DR   EMBL; BC065056; - ;
DR   EMBL; BC094577; - ;
DR   UniProtKB/Swiss-Prot; Q8BXT1; Q505F2; -.
DR   EMBL; AK044337; BAC31874.1; -; mRNA.
DR   EMBL; AK142301; BAE25020.1; -; mRNA.
DR   EMBL; BC065056; AAH65056.1; -; mRNA.
DR   EMBL; BC094577; AAH94577.1; -; mRNA.
DR   IPI; IPI00399848; -.
DR   RefSeq; NP_080656.2; NM_026380.3.
DR   UniGene; Mm.379143; -.
DR   ProteinModelPortal; Q8BXT1; -.
DR   SMR; Q8BXT1; 56-171.
DR   STRING; Q8BXT1; -.
DR   PhosphoSite; Q8BXT1; -.
DR   PRIDE; Q8BXT1; -.
DR   Ensembl; ENSMUST00000041776; ENSMUSP00000045715; ENSMUSG00000042671.
DR   Ensembl; ENSMUST00000111810; ENSMUSP00000107441; ENSMUSG00000042671.
DR   Ensembl; ENSMUST00000111812; ENSMUSP00000107443; ENSMUSG00000042671.
DR   GeneID; 67792; -.
DR   KEGG; mmu:67792; -.
DR   UCSC; uc007dad.1; mouse.
DR   CTD; 85397; -.
DR   MGI; MGI:108408; Rgs8.
DR   eggNOG; roNOG16741; -.
DR   GeneTree; ENSGT00600000084096; -.
DR   InParanoid; Q8BXT1; -.
DR   OMA; SCFDQAQ; -.
DR   OrthoDB; EOG4RV2SM; -.
DR   PhylomeDB; Q8BXT1; -.
DR   NextBio; 325577; -.
DR   ArrayExpress; Q8BXT1; -.
DR   Bgee; Q8BXT1; -.
DR   CleanEx; MM_RGS8; -.
DR   Genevestigator; Q8BXT1; -.
DR   GermOnline; ENSMUSG00000042671; Mus musculus.
DR   GO; GO:0005096; F:GTPase activator activity; TAS:MGI.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signaling pathway; TAS:MGI.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; MOUSE1.PE1953; -.
KW   ENSMUSG000000426715old_1320000031; ENSMUSP000000457151old_1320000031;
KW   D3YYE5_MOUSE; D3Z1V2_MOUSE; D3Z5I4_MOUSE; AC154140; AK044337; AK142301;
KW   BC094577;
KW   Complete proteome; Reference proteome; Signal transduction inhibitor.
SQ   SEQUENCE   180 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA TRWAESFDVL
     LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK LVTKAHRIFE EFVDVQAPRE
     VNIDFQTREA TRKNMQEPSL TCFDQAQGKV HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS
//

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