(data stored in ACNUC17492 zone)

HOGENOM: MOUSE1_PE1962

ID   MOUSE1_PE1962                        STANDARD;      PRT;   201 AA.
AC   MOUSE1_PE1962; P97428; O09091; P97420; Q80V16;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 16; Short=RGS16;AltName:
DE   Full=A28-RGS14P;AltName: Full=Retinal-specific RGS; Short=RGS-r;AltName:
DE   Full=Retinally abundant regulator of G-protein signaling;
DE   (MOUSE1.PE1962).
GN   Name=Rgs16; Synonyms=Rgsr;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE1.PE1962.
CC       Mus musculus chromosome 1 NCBIM37  sequence 1..197195432 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS16_MOUSE
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha,
CC       but not to G(s)-alpha. Plays an important role in the
CC       phototransduction cascade by regulating the lifetime and effective
CC       concentration of activated transducin alpha. May regulate extra
CC       and intracellular mitogenic signals.
CC   -!- TISSUE SPECIFICITY: Retinal; also predominantly expressed in the
CC       liver and pituitary.
CC   -!- PTM: Palmitoylated on Cys-2 and/or Cys-12.
CC   -!- PTM: Phosphorylated on Tyr-167; upon EGFR stimulation. Enhanced
CC       GTPase accelerating (GAP) activity on G(i)-alpha (By similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000026475;ENSMUST00000027748;ENSMUSP00000027748.
DR   EMBL; AK079543; - ;
DR   EMBL; AK154324; - ;
DR   EMBL; BC010980; - ;
DR   EMBL; BC049968; - ;
DR   EMBL; BC055459; - ;
DR   EMBL; CH466520; - ;
DR   EMBL; U67189; - ;
DR   EMBL; U70427; - ;
DR   EMBL; U72881; - ;
DR   EMBL; U94828; - ;
DR   UniProtKB/Swiss-Prot; P97428; O09091; P97420; Q80V16; -.
DR   EMBL; U72881; AAC52927.1; -; mRNA.
DR   EMBL; U67189; AAB50619.1; -; mRNA.
DR   EMBL; U70427; AAC16913.1; -; Genomic_DNA.
DR   EMBL; U94828; AAC53549.1; -; mRNA.
DR   EMBL; BC010980; AAH10980.1; -; mRNA.
DR   EMBL; BC049968; AAH49968.2; -; mRNA.
DR   IPI; IPI00125305; -.
DR   RefSeq; NP_035397.2; NM_011267.3.
DR   UniGene; Mm.181709; -.
DR   PDB; 3C7K; X-ray; 2.90 A; B/D=53-180.
DR   PDB; 3C7L; X-ray; 1.89 A; A/B=53-180.
DR   PDBsum; 3C7K; -.
DR   PDBsum; 3C7L; -.
DR   ProteinModelPortal; P97428; -.
DR   SMR; P97428; 6-186.
DR   DIP; DIP-29922N; -.
DR   IntAct; P97428; 1.
DR   STRING; P97428; -.
DR   PhosphoSite; P97428; -.
DR   PRIDE; P97428; -.
DR   Ensembl; ENSMUST00000027748; ENSMUSP00000027748; ENSMUSG00000026475.
DR   GeneID; 19734; -.
DR   KEGG; mmu:19734; -.
DR   CTD; 6004; -.
DR   MGI; MGI:108407; Rgs16.
DR   eggNOG; roNOG14080; -.
DR   InParanoid; P97428; -.
DR   OMA; PAEPSHT; -.
DR   OrthoDB; EOG4STS5S; -.
DR   PhylomeDB; P97428; -.
DR   NextBio; 297168; -.
DR   ArrayExpress; P97428; -.
DR   Bgee; P97428; -.
DR   CleanEx; MM_RGS16; -.
DR   Genevestigator; P97428; -.
DR   GermOnline; ENSMUSG00000026475; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; TAS:MGI.
DR   GO; GO:0005096; F:GTPase activator activity; TAS:MGI.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signaling pathway; TAS:MGI.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; MOUSE1.PE1962; -.
KW   ENSMUSG000000264755old_1320000031; ENSMUSP000000277481old_1320000031;
KW   Q542U0_MOUSE; Q7TNU9_MOUSE; AK079543; AK154324; BC010980; BC049968;
KW   CH466520; U67189; U70427; U72881; U94828;
KW   3D-structure; Complete proteome; Lipoprotein; Palmitate;
KW   Phosphoprotein; Reference proteome; Signal transduction inhibitor.
SQ   SEQUENCE   201 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MCRTLATFPN TCLERAKEFK TRLGIFLHKS ELSSDTGGIS KFEWASKHNK ERSFSEDVLG
     WRESFDLLLN SKNGVAAFHA FLKTEFSEEN LEFWLACEEF KKIRSATKLA SRAHHIFDEY
     IRSEAPKEVN IDHETRELTK TNLQAATTSC FDVAQGKTRT LMEKDSYPRF LKSPAYRDLA
     AQASATSTSA PSGSPAEPSH T
//

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