(data stored in ACNUC17492 zone)

HOGENOM: MOUSE1_PE2256

ID   MOUSE1_PE2256                        STANDARD;      PRT;   205 AA.
AC   MOUSE1_PE2256; O08899; Q99L30;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 4; Short=RGS4;
DE   (MOUSE1.PE2256).
GN   Name=Rgs4;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE1.PE2256.
CC       Mus musculus chromosome 1 NCBIM37  sequence 1..197195432 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS4_MOUSE
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Activity on G(z)-alpha is inhibited
CC       by phosphorylation of the G-protein. Activity on G(z)-alpha and
CC       G(i)-alpha-1 is inhibited by palmitoylation of the G-protein (By
CC       similarity).
CC   -!- TISSUE SPECIFICITY: Expressed at high levels in brain, moderately
CC       low levels in heart, and very low levels in lung, liver, and
CC       skeletal muscle.
CC   -!- PTM: Either Cys-2 or Cys-12 or both are palmitoylated (By
CC       similarity).
CC   -!- PTM: Phosphorylated by cyclic GMP-dependent protein kinase (By
CC       similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000038530;ENSMUST00000027991;ENSMUSP00000027991.
DR   EMBL; AB004315; - ;
DR   EMBL; AK030536; - ;
DR   EMBL; AK039134; - ;
DR   EMBL; BC003882; - ;
DR   EMBL; BC055293; - ;
DR   EMBL; DQ346659; - ;
DR   EMBL; DQ346660; - ;
DR   EMBL; DQ346661; - ;
DR   UniProtKB/Swiss-Prot; O08899; Q99L30; -.
DR   EMBL; AB004315; BAA20400.1; -; mRNA.
DR   EMBL; BC003882; AAH03882.1; -; mRNA.
DR   IPI; IPI00116495; -.
DR   RefSeq; NP_033088.2; NM_009062.3.
DR   UniGene; Mm.41642; -.
DR   ProteinModelPortal; O08899; -.
DR   SMR; O08899; 6-183.
DR   STRING; O08899; -.
DR   PhosphoSite; O08899; -.
DR   PRIDE; O08899; -.
DR   GeneID; 19736; -.
DR   KEGG; mmu:19736; -.
DR   CTD; 5999; -.
DR   MGI; MGI:108409; Rgs4.
DR   eggNOG; roNOG16162; -.
DR   InParanoid; O08899; -.
DR   OrthoDB; EOG4PK297; -.
DR   ArrayExpress; O08899; -.
DR   Bgee; O08899; -.
DR   CleanEx; MM_RGS4; -.
DR   Genevestigator; O08899; -.
DR   GermOnline; ENSMUSG00000038530; Mus musculus.
DR   GO; GO:0005096; F:GTPase activator activity; TAS:MGI.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signaling pathway; TAS:MGI.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; MOUSE1.PE2256; -.
KW   ENSMUSG000000385305old_1320000031; ENSMUSP000000279911old_1320000031;
KW   Q5D078_MOUSE; AB004315; AK030536; AK039134; BC003882; BC055293; DQ346659;
KW   DQ346661;
KW   Complete proteome; Lipoprotein; Palmitate; Phosphoprotein;
KW   Reference proteome; Signal transduction inhibitor.
SQ   SEQUENCE   205 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHSSSHS KKDKVVTCQR VSQEEVKKWA
     ESLENLIHHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS
     VQATKEVNLD SCTREETSRN MLQPTITCFD EAQKKIFNLM EKDSYRRFLK SRFYLDLTNP
     SSCGAEKQKG AKSSADCTSL VSQCA
//

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