(data stored in ACNUC3582 zone)

HOGENOM: MOUSE1_PE89

ID   MOUSE1_PE89                          STANDARD;      PRT;   870 AA.
AC   MOUSE1_PE89; Q8K007; Q6ZPZ0; Q8BLJ0; Q8C1D3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Extracellular sulfatase Sulf-1; Short=mSulf-1; EC=3.1.6
DE   -;Flags: Precursor; (MOUSE1.PE89).
GN   Name=Sulf1; Synonyms=Kiaa1077;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE1.PE89.
CC       Mus musculus chromosome 1 NCBIM37  sequence 1..197195432 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:SULF1_MOUSE
CC   -!- FUNCTION: Exhibits arylsulfatase activity and highly specific
CC       endoglucosamine-6-sulfatase activity. It can remove sulfate from
CC       the C-6 position of glucosamine within specific subregions of
CC       intact heparin. Diminishes HSPG (heparan sulfate proteoglycans)
CC       sulfation, inhibits signaling by heparin-dependent growth factors,
CC       diminishes proliferation, and facilitates apoptosis in response to
CC       exogenous stimulation (By similarity).
CC   -!- COFACTOR: Binds 1 calcium ion per subunit (By similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum (By similarity). Golgi
CC       apparatus, Golgi stack (By similarity). Cell surface (By
CC       similarity). Note=Also localized on the cell surface (By
CC       similarity).
CC   -!- PTM: The conversion to 3-oxoalanine (also known as C-
CC       formylglycine, FGly), of a serine or cysteine residue in
CC       prokaryotes and of a cysteine residue in eukaryotes, is critical
CC       for catalytic activity (By similarity).
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC32179.1; Type=Miscellaneous discrepancy; Note=Intron retention;
CC       Sequence=BAC98088.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=BAC98088.1; Type=Miscellaneous discrepancy; Note=Intron retention. The sequence is a pre-RNA and intronic sequences remain;
CC   -!- GENE_FAMILY: HOG000290161 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000016918;ENSMUST00000088585;ENSMUSP00000085949.
DR   EMBL; AK028285; - ;
DR   EMBL; AK045002; - ;
DR   EMBL; AK129278; - ;
DR   EMBL; AY101178; - ;
DR   EMBL; BC034547; - ;
DR   EMBL; BC049276; - ;
DR   UniProtKB/Swiss-Prot; Q8K007; Q6ZPZ0; Q8BLJ0; Q8C1D3; -.
DR   EMBL; AY101178; AAM76863.1; -; mRNA.
DR   EMBL; AK129278; BAC98088.1; ALT_SEQ; Transcribed_RNA.
DR   EMBL; AK028285; BAC25858.1; -; mRNA.
DR   EMBL; AK045002; BAC32179.1; ALT_SEQ; mRNA.
DR   EMBL; BC034547; AAH34547.1; -; mRNA.
DR   EMBL; BC049276; AAH49276.1; -; mRNA.
DR   IPI; IPI00111481; -.
DR   RefSeq; NP_001185494.1; NM_001198565.1.
DR   RefSeq; NP_001185495.1; NM_001198566.1.
DR   RefSeq; NP_758498.1; NM_172294.1.
DR   UniGene; Mm.45563; -.
DR   ProteinModelPortal; Q8K007; -.
DR   SMR; Q8K007; 279-386.
DR   STRING; Q8K007; -.
DR   PRIDE; Q8K007; -.
DR   Ensembl; ENSMUST00000088585; ENSMUSP00000085949; ENSMUSG00000016918.
DR   GeneID; 240725; -.
DR   KEGG; mmu:240725; -.
DR   UCSC; uc007aia.2; mouse.
DR   CTD; 23213; -.
DR   MGI; MGI:2138563; Sulf1.
DR   eggNOG; roNOG15290; -.
DR   GeneTree; ENSGT00400000022041; -.
DR   OrthoDB; EOG4VT5WH; -.
DR   PhylomeDB; Q8K007; -.
DR   NextBio; 384701; -.
DR   ArrayExpress; Q8K007; -.
DR   Bgee; Q8K007; -.
DR   CleanEx; MM_SULF1; -.
DR   Genevestigator; Q8K007; -.
DR   GermOnline; ENSMUSG00000016918; Mus musculus.
DR   GO; GO:0009986; C:cell surface; ISS:UniProtKB.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
DR   GO; GO:0004065; F:arylsulfatase activity; ISS:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0060348; P:bone development; IGI:BHF-UCL.
DR   GO; GO:0001822; P:kidney development; IGI:BHF-UCL.
DR   GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IGI:BHF-UCL.
DR   InterPro; IPR017849; Alkaline_Pase-like_a/b/a.
DR   InterPro; IPR017850; Alkaline_phosphatase_core.
DR   InterPro; IPR014615; Extracellular_sulfatase.
DR   InterPro; IPR000917; Sulfatase.
DR   Gene3D; G3DSA:3.40.720.10; Alk_phosphtse; 3.
DR   Pfam; PF00884; Sulfatase; 1.
DR   PIRSF; PIRSF036665; Sulf1; 1.
DR   SUPFAM; SSF53649; Alkaline_phosphatase_core; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
DR   PROSITE; PS00149; SULFATASE_2; FALSE_NEG.
DR   HOGENOMDNA; MOUSE1.PE89; -.
KW   ENSMUSG000000169185old_1320000031; ENSMUSP000000859491old_1320000031;
KW   AK028285; AK045002; AK129278; AY101178; BC034547; BC049276;
KW   Apoptosis; Calcium; Complete proteome; Endoplasmic reticulum;
KW   Glycoprotein; Golgi apparatus; Hydrolase; Metal-binding;
KW   Reference proteome; Signal.
SQ   SEQUENCE   870 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKYSLWALLL AVLGTQLLGS LCSTVRSQRF RGRIQQERKN IRPNIILVLT DDQDVELGSL
     QVMNKTRKIM EQGGATFTNA FVTTPMCCPS RSSMLTGKYV HNHNVYTNNE NCSSPSWQAM
     HEPRTFAVYL NNTGYRTAFF GKYLNEYNGS YIPPGWREWL GLIKNSRFYN YTVCRNGIKE
     KHGFDYAKDY FTDLITNESI NYFKMSKRMY PHRPIMMVIS HAAPHGPEDS APQFSKLYPN
     ASQHITPSYN YAPNMDKHWI MQYTGPMLPI HMEFTNVLQR KRLQTLMSVD DSVERLYNML
     VESGELDNTY IIYTADHGYH IGQFGLVKGK SMPYDFDIRV PFFIRGPSIE PGSIVPQIVL
     NIDLAPTILD IAGLDSPSDV DGKSVLKLLD LEKPGNRFRT NKKAKIWRDT FLVERGKFLR
     KKEESGKNIQ QSNHLPKYER VKELCQQARY QTACEQPGQN WQCIEDTSGK LRIHKCKGPS
     DLLTVRQNAR NLYSRGLHDK DKECHCRDSG YRSSRSQRKN QRQFLRNKGT PKYKPRFVHT
     RQTRSLSVEF EGEIYDINLE EEELQVLPPR SIAKRHDEGH QGFIGHQAAA GDIRNEMLAD
     SNNAVGLPAT VRVTHKCFIL PNDTIHCERE LYQSARAWKD HKAYIDKEIE VLQDKIKNLR
     EVRGHLKKRK PEECGCGDQS YYNKEKGVKR QEKLKSHLHP FKEAAAQEVD SKLQLFKEHR
     RRKKERKEKK RQRKGEECSL PGLTCFTHDN NHWQTAPFWN LGSFCACTSS NNNTYWCLRT
     VNETHNFLFC EFATGFLEYF DMNTDPYQLT NTVHTVERSI LNQLHIQLME LRSCQGYKQC
     NPRPKSLDIG AKEGGNYDPH RGQLWDGWEG
//

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