(data stored in ACNUC22665 zone)

HOGENOM: MOUSE3_PE1516

ID   MOUSE3_PE1516                        STANDARD;      PRT;   344 AA.
AC   MOUSE3_PE1516; P08920; Q61394;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=T-cell surface antigen CD2;AltName: Full=LFA-2;AltName:
DE   Full=LFA-3 receptor;AltName: Full=Lymphocyte antigen 37;
DE   Short=Ly-37;AltName: Full=T-cell surface antigen T11/Leu-5;AltName:
DE   CD_antigen=CD2;Flags: Precursor; (MOUSE3.PE1516).
GN   Name=Cd2; Synonyms=Ly-37;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE3.PE1516.
CC       Mus musculus chromosome 3 NCBIM37  sequence 1..159599783 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CD2_MOUSE
CC   -!- FUNCTION: CD2 interacts with lymphocyte function-associated
CC       antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells
CC       and other cell types. CD2 is implicated in the triggering of T-
CC       cells, the cytoplasmic domain is implicated in the signaling
CC       function.
CC   -!- SUBUNIT: Interacts with CD2AP and PSTPIP1.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like)
CC       domain.
CC   -!- SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like)
CC       domain.
CC   -!- GENE_FAMILY: HOG000276890 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000027863;ENSMUST00000029456;ENSMUSP00000029456.
DR   EMBL; AC131184; - ;
DR   EMBL; AF065906; - ;
DR   EMBL; AF065907; - ;
DR   EMBL; AF065908; - ;
DR   EMBL; AF065909; - ;
DR   EMBL; AF306543; - ;
DR   EMBL; AL645930; - ;
DR   EMBL; AL672260; - ;
DR   EMBL; BC053731; - ;
DR   EMBL; CH466608; - ;
DR   EMBL; M18934; - ;
DR   EMBL; M19799; - ;
DR   EMBL; M19801; - ;
DR   EMBL; M19803; - ;
DR   EMBL; M19805; - ;
DR   EMBL; M19807; - ;
DR   EMBL; X06143; - ;
DR   EMBL; Y00023; - ;
DR   UniProtKB/Swiss-Prot; P08920; Q61394; -.
DR   EMBL; Y00023; CAA68258.1; -; mRNA.
DR   EMBL; X06143; CAA29500.1; -; mRNA.
DR   EMBL; M19807; AAA37393.1; -; Genomic_DNA.
DR   EMBL; M19799; AAA37393.1; JOINED; Genomic_DNA.
DR   EMBL; M19801; AAA37393.1; JOINED; Genomic_DNA.
DR   EMBL; M19803; AAA37393.1; JOINED; Genomic_DNA.
DR   EMBL; M19805; AAA37393.1; JOINED; Genomic_DNA.
DR   EMBL; M18934; AAA37397.1; -; mRNA.
DR   EMBL; BC053731; AAH53731.1; -; mRNA.
DR   IPI; IPI00108001; -.
DR   PIR; I49585; I49585.
DR   RefSeq; NP_038514.1; NM_013486.2.
DR   UniGene; Mm.22842; -.
DR   ProteinModelPortal; P08920; -.
DR   SMR; P08920; 24-199.
DR   MINT; MINT-1769762; -.
DR   STRING; P08920; -.
DR   PRIDE; P08920; -.
DR   Ensembl; ENSMUST00000029456; ENSMUSP00000029456; ENSMUSG00000027863.
DR   GeneID; 12481; -.
DR   KEGG; mmu:12481; -.
DR   CTD; 914; -.
DR   MGI; MGI:88320; Cd2.
DR   eggNOG; roNOG16173; -.
DR   InParanoid; P08920; -.
DR   OMA; HQQKGPP; -.
DR   OrthoDB; EOG4H9XMK; -.
DR   PhylomeDB; P08920; -.
DR   NextBio; 281378; -.
DR   ArrayExpress; P08920; -.
DR   Bgee; P08920; -.
DR   CleanEx; MM_CD2; -.
DR   Genevestigator; P08920; -.
DR   GermOnline; ENSMUSG00000027863; Mus musculus.
DR   GO; GO:0046658; C:anchored to plasma membrane; IDA:MGI.
DR   GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR   GO; GO:0005576; C:extracellular region; IDA:MGI.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009898; C:internal side of plasma membrane; IDA:MGI.
DR   GO; GO:0043499; F:eukaryotic cell surface binding; IDA:MGI.
DR   GO; GO:0042803; F:protein homodimerization activity; IDA:MGI.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR008424; Ig_C2-set.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR015631; Signal_lymphocyte_activ_molc.
DR   InterPro; IPR015632; T-cell_sdhesion_molc_CD2.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 2.
DR   PANTHER; PTHR12080:SF10; CD2_pre; 1.
DR   PANTHER; PTHR12080; SLAM_related; 1.
DR   Pfam; PF05790; C2-set; 1.
DR   Pfam; PF07686; V-set; 1.
DR   PRINTS; PR01870; CD2ANTIGEN.
DR   PROSITE; PS50835; IG_LIKE; FALSE_NEG.
DR   HOGENOMDNA; MOUSE3.PE1516; -.
KW   ENSMUSG000000278635old_1320000031; ENSMUSP000000294561old_1320000031;
KW   D3Z1E1_MOUSE; Q549Q4_MOUSE; Q9R201_MOUSE; AC131184; AF065906; AF065907;
KW   AF065909; AF306543; AL645930; AL672260; BC053731; CH466608; M18934;
KW   M19801; M19803; M19805; M19807; X06143; Y00023;
KW   Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
SQ   SEQUENCE   344 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKCKFLGSFF LLFSLSGKGA DCRDNETIWG VLGHGITLNI PNFQMTDDID EVRWVRRGTL
     VAEFKRKKPP FLISETYEVL ANGSLKIKKP MMRNDSGTYN VMVYGTNGMT RLEKDLDVRI
     LERVSKPMIH WECPNTTLTC AVLQGTDFEL KLYQGETLLN SLPQKNMSYQ WTNLNAPFKC
     EAINPVSKES KMEVVNCPEK GLSFYVTVGV GAGGLLLVLL VALFIFCICK RRKRNRRRKD
     EELEIKASRT STVERGPKPH STPAAAAQNS VALQAPPPPG HHLQTPGHRP LPPGHRTREH
     QQKKRPPPSG TQIHQQKGPP LPRPRVQPKP PCGSGDGVSL PPPN
//

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