(data stored in ACNUC8465 zone)

HOGENOM: MOUSE3_PE1612

ID   MOUSE3_PE1612                        STANDARD;      PRT;   193 AA.
AC   MOUSE3_PE1612; Q62159; Q3TUN0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Rho-related GTP-binding protein RhoC;AltName:
DE   Full=Silica-induced gene 61 protein; Short=SIG-61;Flags: Precursor;
DE   (MOUSE3.PE1612).
GN   Name=Rhoc; Synonyms=Arhc;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE3.PE1612.
CC       Mus musculus chromosome 3 NCBIM37  sequence 1..159599783 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:RHOC_MOUSE
CC   -!- FUNCTION: Regulates a signal transduction pathway linking plasma
CC       membrane receptors to the assembly of focal adhesions and actin
CC       stress fibers.
CC   -!- SUBUNIT: Binds ROCK1 and ROCK2 (By similarity). Interacts with
CC       AKAP13 (By similarity). Interacts with RTKN.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (Potential).
CC   -!- INDUCTION: Up-regulated in silica-treated macrophages.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC   -!- GENE_FAMILY: HOG000233974 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000002233;ENSMUST00000106787;ENSMUSP00000102399.
DR   EMBL; AK011599; - ;
DR   EMBL; AK152802; - ;
DR   EMBL; AK160650; - ;
DR   EMBL; BC004627; - ;
DR   EMBL; X80638; - ;
DR   UniProtKB/Swiss-Prot; Q62159; Q3TUN0; -.
DR   EMBL; X80638; CAA56682.1; -; mRNA.
DR   EMBL; AK011599; BAB27724.1; -; mRNA.
DR   EMBL; AK152802; BAE31507.1; -; mRNA.
DR   EMBL; AK160650; BAE35941.1; -; mRNA.
DR   EMBL; BC004627; AAH04627.1; -; mRNA.
DR   IPI; IPI00122245; -.
DR   RefSeq; NP_031510.2; NM_007484.2.
DR   UniGene; Mm.262; -.
DR   PDB; 2GCP; X-ray; 2.15 A; A=1-181.
DR   PDBsum; 2GCP; -.
DR   ProteinModelPortal; Q62159; -.
DR   SMR; Q62159; 3-179.
DR   STRING; Q62159; -.
DR   PhosphoSite; Q62159; -.
DR   PRIDE; Q62159; -.
DR   Ensembl; ENSMUST00000002303; ENSMUSP00000002303; ENSMUSG00000002233.
DR   Ensembl; ENSMUST00000106787; ENSMUSP00000102399; ENSMUSG00000002233.
DR   GeneID; 11853; -.
DR   KEGG; mmu:11853; -.
DR   UCSC; uc009rpe.2; mouse.
DR   CTD; 389; -.
DR   MGI; MGI:106028; Rhoc.
DR   eggNOG; maNOG05341; -.
DR   GeneTree; ENSGT00550000074256; -.
DR   InParanoid; Q62159; -.
DR   OMA; RRGCPLL; -.
DR   OrthoDB; EOG4G4GRD; -.
DR   PhylomeDB; Q62159; -.
DR   NextBio; 279829; -.
DR   ArrayExpress; Q62159; -.
DR   Bgee; Q62159; -.
DR   CleanEx; MM_RHOC; -.
DR   Genevestigator; Q62159; -.
DR   GermOnline; ENSMUSG00000002233; Mus musculus.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00174; RHO; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
DR   HOGENOMDNA; MOUSE3.PE1612; -.
KW   ENSMUSG000000022335old_1320000031; ENSMUSP000001023991old_1320000031;
KW   AK011599; AK152802; AK160650; BC004627; X80638;
KW   3D-structure; Cell membrane; Complete proteome; GTP-binding;
KW   Lipoprotein; Membrane; Methylation; Nucleotide-binding;
KW   Phosphoprotein; Prenylation; Reference proteome.
SQ   SEQUENCE   193 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG KQVELALWDT
     AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD
     LRQDEHTRRE LAKMKQEPVR SEEGRDMANR ISAFGYLECS AKTKEGVREV FEMATRAGLQ
     VRKNKRRRGC PIL
//

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