(data stored in ACNUC16324 zone)

HOGENOM: MOUSE4_PE2922

ID   MOUSE4_PE2922                        STANDARD;      PRT;   753 AA.
AC   MOUSE4_PE2922; Q4PZA2; B1AXF9; Q4PZ99; Q4PZA1; Q6P9Q9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Endothelin-converting enzyme 1; Short=ECE-1; EC=3.4.24 71;
DE   (MOUSE4.PE2922).
GN   Name=Ece1;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE4.PE2922.
CC       Mus musculus chromosome 4 NCBIM37  sequence 1..155630120 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ECE1_MOUSE
CC   -!- FUNCTION: Converts big endothelin-1 to endothelin-1 (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of the 21-Trp-|-Val-22 bond in big
CC       endothelin to form endothelin 1.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- ENZYME REGULATION: Inhibited by phosphoramidon (By similarity).
CC   -!- SUBUNIT: Homodimer; disulfide-linked (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane
CC       protein (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=B;
CC         IsoId=Q4PZA2-1; Sequence=Displayed;
CC       Name=A;
CC         IsoId=Q4PZA2-2; Sequence=VSP_019399;
CC       Name=C;
CC         IsoId=Q4PZA2-3; Sequence=VSP_019400;
CC       Name=D;
CC         IsoId=Q4PZA2-4; Sequence=VSP_019401;
CC   -!- SIMILARITY: Belongs to the peptidase M13 family.
CC   -!- GENE_FAMILY: HOG000245574 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000057530;ENSMUST00000102518;ENSMUSP00000099576.
DR   EMBL; AK134088; - ;
DR   EMBL; AK160504; - ;
DR   EMBL; AL807764; - ;
DR   EMBL; BC060648; - ;
DR   EMBL; DQ022721; - ;
DR   EMBL; DQ022722; - ;
DR   EMBL; DQ022723; - ;
DR   EMBL; DQ022724; - ;
DR   EMBL; DQ022725; - ;
DR   EMBL; DQ022726; - ;
DR   EMBL; DQ022727; - ;
DR   EMBL; DQ022728; - ;
DR   EMBL; DQ022729; - ;
DR   EMBL; DQ022730; - ;
DR   EMBL; DQ022731; - ;
DR   EMBL; DQ022732; - ;
DR   EMBL; DQ022733; - ;
DR   EMBL; DQ022734; - ;
DR   EMBL; DQ022735; - ;
DR   EMBL; DQ022736; - ;
DR   EMBL; DQ022737; - ;
DR   EMBL; DQ022738; - ;
DR   EMBL; DQ022739; - ;
DR   EMBL; DQ022740; - ;
DR   EMBL; DQ022741; - ;
DR   UniProtKB/Swiss-Prot; Q4PZA2; B1AXF9; Q4PZ99; Q4PZA1; Q6P9Q9; -.
DR   EMBL; DQ022741; AAY81993.1; -; Genomic_DNA.
DR   EMBL; DQ022723; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022725; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022727; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022726; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022728; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022730; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022732; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022734; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022736; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022740; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022739; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022738; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022737; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022735; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022733; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022731; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022729; AAY81993.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022741; AAY81995.1; -; Genomic_DNA.
DR   EMBL; DQ022721; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022723; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022725; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022726; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022728; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022730; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022732; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022734; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022736; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022740; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022739; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022738; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022737; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022735; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022733; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022731; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022729; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022727; AAY81995.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022741; AAY81996.1; -; Genomic_DNA.
DR   EMBL; DQ022722; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022723; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022725; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022726; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022728; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022730; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022732; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022734; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022736; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022740; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022739; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022738; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022737; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022735; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022733; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022731; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022729; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022727; AAY81996.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022741; AAY81997.1; -; Genomic_DNA.
DR   EMBL; DQ022724; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022725; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022727; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022726; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022728; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022730; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022732; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022734; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022736; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022740; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022739; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022738; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022737; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022735; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022733; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022731; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; DQ022729; AAY81997.1; JOINED; Genomic_DNA.
DR   EMBL; AK134088; BAE22007.1; -; mRNA.
DR   EMBL; AL807764; CAM23372.1; -; Genomic_DNA.
DR   EMBL; BC060648; AAH60648.1; -; mRNA.
DR   IPI; IPI00396840; -.
DR   IPI; IPI00648026; -.
DR   IPI; IPI00762055; -.
DR   IPI; IPI00762815; -.
DR   RefSeq; NP_955011.1; NM_199307.2.
DR   UniGene; Mm.401062; -.
DR   UniGene; Mm.483336; -.
DR   ProteinModelPortal; Q4PZA2; -.
DR   SMR; Q4PZA2; 100-769.
DR   STRING; Q4PZA2; -.
DR   MEROPS; M13.002; -.
DR   PhosphoSite; Q4PZA2; -.
DR   PRIDE; Q4PZA2; -.
DR   Ensembl; ENSMUST00000073194; ENSMUSP00000072932; ENSMUSG00000057530.
DR   Ensembl; ENSMUST00000102518; ENSMUSP00000099576; ENSMUSG00000057530.
DR   GeneID; 230857; -.
DR   KEGG; mmu:230857; -.
DR   UCSC; uc008vju.2; mouse.
DR   UCSC; uc008vjv.1; mouse.
DR   CTD; 1889; -.
DR   MGI; MGI:1101357; Ece1.
DR   GeneTree; ENSGT00550000074200; -.
DR   InParanoid; Q4PZA2; -.
DR   OMA; AIASKHW; -.
DR   OrthoDB; EOG4P2Q1N; -.
DR   NextBio; 380214; -.
DR   ArrayExpress; Q4PZA2; -.
DR   Bgee; Q4PZA2; -.
DR   CleanEx; MM_ECE1; -.
DR   Genevestigator; Q4PZA2; -.
DR   GermOnline; ENSMUSG00000057530; Mus musculus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0060037; P:pharyngeal system development; IMP:MGI.
DR   InterPro; IPR024079; MetalloPept_cat_dom.
DR   InterPro; IPR000718; Peptidase_M13.
DR   InterPro; IPR018497; Peptidase_M13_C.
DR   InterPro; IPR008753; Peptidase_M13_N.
DR   Gene3D; G3DSA:3.40.390.10; G3DSA:3.40.390.10; 2.
DR   PANTHER; PTHR11733; Peptidase_M13; 1.
DR   Pfam; PF01431; Peptidase_M13; 1.
DR   Pfam; PF05649; Peptidase_M13_N; 1.
DR   PRINTS; PR00786; NEPRILYSIN.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
DR   HOGENOMDNA; MOUSE4.PE2922; -.
KW   ENSMUSG000000575305old_1320000031; ENSMUSP000000995761old_1320000031;
KW   Q3TUZ3_MOUSE; AK134088; AK160504; AL807764; BC060648; DQ022721; DQ022722;
KW   DQ022724; DQ022725; DQ022726; DQ022727; DQ022728; DQ022729; DQ022730;
KW   DQ022732; DQ022733; DQ022734; DQ022735; DQ022736; DQ022737; DQ022738;
KW   DQ022740; DQ022741;
KW   Alternative splicing; Cell membrane; Complete proteome;
KW   Disulfide bond; Glycoprotein; Hydrolase; Membrane; Metal-binding;
KW   Metalloprotease; Phosphoprotein; Protease; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix; Zinc.
SQ   SEQUENCE   753 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSTYKRATLD EEDLVDSLSE GDVYPNGLQV NFRSSRSGQR CWAARTSVEK RLVVLVTLLA
     AGLVACLAAL GIQYQTRTPP VCLTEACVSV TSSILNSMDP TVDPCQDFFS YACGGWIKAN
     PVPDGHSRWG TFSNLWEHNQ AVIKHLLENA TASVSEAERK AQVYYRACMN ETRIEELRAK
     PLMELIEKLG GWNITGPWAK DNFQDTLQVV TAHYRTSPFF SVYVSADSKN SNSNVIQVDQ
     SGLGLPSRDY YLNKTENEKV LTGYLNYMVQ LGKLLGGGDE DAIRPQMQQI LDFETALANI
     TIPQEKRRDE ELIYHKVTAA ELQTLAPAIN WLPFLNTIFY PVEINESEPI VVYDKEYLRQ
     VSTLINNTDK CLLNNYMMWN LVRKTSSFLD QRFQDADEKF MEVMYGTKKT CIPRWKFCVS
     DTENNLGFAL GPMFVKATFA EDSKNIASEI IMEIKKAFEE SLSTLKWMDE ETRRSAKEKA
     DAIYNMIGYP NFIMDPKELD KVFNDYTAVP DLYFENAMRF FNFSWRVTAD QLRKAPNRDQ
     WSMTPPMVNA YYSPTKNEIV FPAGILQAPF YTRSSPNALN FGGIGVVVGH ELTHAFDDQG
     REYDKDGNLR PWWKNSSVEA FKQQTECMVQ QYSNYSVNGE PVNGRHTLGE NIADNGGLKA
     AYRAYQNWVK KNGAEQTLPT LGLTSNQLFF LGFAQVWCSV RTPESSHEGL ITDPHSPSRF
     RVIGSLSNSK EFSEHFRCPP GSPMNPHHKC EVW
//

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