(data stored in ACNUC16935 zone)

HOGENOM: MOUSE4_PE3752

ID   MOUSE4_PE3752                        STANDARD;      PRT;   161 AA.
AC   MOUSE4_PE3752; Q64339; Q8K0H3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Ubiquitin-like protein ISG15;AltName:
DE   Full=Interferon-induced 15 kDa protein;AltName: Full=Interferon-induced
DE   17 kDa protein; Short=IP17;AltName: Full=Ubiquitin cross-reactive
DE   protein;Flags: Precursor; (MOUSE4.PE3752).
GN   Name=Isg15; Synonyms=G1p2, Ucrp;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE4.PE3752.
CC       Mus musculus chromosome 4 NCBIM37  sequence 1..155630120 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ISG15_MOUSE
CC   -!- FUNCTION: Ubiquitin-like protein that is conjugated to
CC       intracellular target proteins after IFN-alpha or IFN-beta
CC       stimulation. Its enzymatic pathway is partially distinct from that
CC       of ubiquitin, differing in substrate specificity and interaction
CC       with ligating enzymes. ISG15 conjugation pathway uses a dedicated
CC       E1 enzyme, but seems to converge with the Ub conjugation pathway
CC       at the level of a specific E2 enzyme. Targets include STAT1,
CC       SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA,
CC       and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic
CC       activity towards neutrophils and activates them to induce release
CC       of eosinophil chemotactic factors. May serve as a trans-acting
CC       binding factor directing the association of ligated target
CC       proteins to intermediate filaments. May also be involved in
CC       autocrine, paracrine and endocrine mechanisms, as in cell-to-cell
CC       signaling, possibly partly by inducing IFN-gamma secretion by
CC       monocytes and macrophages. Seems to display antiviral activity
CC       during viral infections (By similarity).
CC   -!- FUNCTION: In response to IFN-tau secreted by the conceptus, may
CC       ligate to and regulate proteins involved in the release of
CC       prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus
CC       luteum and maintain the pregnancy.
CC   -!- SUBUNIT: Interacts with, and is conjugated to its targets by the
CC       UBE1L (E1 enzyme) and UBE2E2 (E2 enzyme) (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Secreted (By similarity).
CC       Note=UCRP conjugates seem to be noncovalently associated with the
CC       intermediate filaments and distributed in a punctate pattern. Also
CC       secreted (By similarity).
CC   -!- INDUCTION: By type I interferons.
CC   -!- MASS SPECTROMETRY: Mass=17015; Method=MALDI; Range=2-155;
CC       Source=PubMed:12963022;
CC   -!- SIMILARITY: Contains 2 ubiquitin-like domains.
CC   -!- GENE_FAMILY: HOG000233942 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000035692;ENSMUST00000085425;ENSMUSP00000082548.
DR   EMBL; BC031424; - ;
DR   EMBL; BC083156; - ;
DR   EMBL; BC109346; - ;
DR   EMBL; CH466594; - ;
DR   EMBL; CT010333; - ;
DR   EMBL; U58202; - ;
DR   EMBL; X56602; - ;
DR   UniProtKB/Swiss-Prot; Q64339; Q8K0H3; -.
DR   EMBL; X56602; CAA39939.1; -; mRNA.
DR   EMBL; U58202; AAB02697.1; -; Genomic_DNA.
DR   EMBL; BC031424; AAH31424.1; -; mRNA.
DR   EMBL; BC083156; AAH83156.1; -; mRNA.
DR   IPI; IPI00555085; -.
DR   PIR; S26434; S26434.
DR   RefSeq; NP_056598.2; NM_015783.3.
DR   UniGene; Mm.451527; -.
DR   UniGene; Mm.4950; -.
DR   ProteinModelPortal; Q64339; -.
DR   SMR; Q64339; 3-154.
DR   STRING; Q64339; -.
DR   PhosphoSite; Q64339; -.
DR   PRIDE; Q64339; -.
DR   Ensembl; ENSMUST00000085425; ENSMUSP00000082548; ENSMUSG00000035692.
DR   GeneID; 100038882; -.
DR   KEGG; mmu:100038882; -.
DR   CTD; 9636; -.
DR   MGI; MGI:1855694; Isg15.
DR   GeneTree; ENSGT00550000074658; -.
DR   InParanoid; Q64339; -.
DR   OMA; FMNLRLR; -.
DR   OrthoDB; EOG4CNQSF; -.
DR   NextBio; 445160; -.
DR   ArrayExpress; Q64339; -.
DR   Bgee; Q64339; -.
DR   CleanEx; MM_ISG15; -.
DR   Genevestigator; Q64339; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005515; F:protein binding; IPI:MGI.
DR   GO; GO:0031386; F:protein tag; IDA:MGI.
DR   GO; GO:0032020; P:ISG15-protein conjugation; IDA:MGI.
DR   GO; GO:0019941; P:modification-dependent protein catabolic process; IDA:MGI.
DR   GO; GO:0009615; P:response to virus; IEA:UniProtKB-KW.
DR   InterPro; IPR000626; Ubiquitin.
DR   InterPro; IPR019955; Ubiquitin_supergroup.
DR   Pfam; PF00240; ubiquitin; 2.
DR   SMART; SM00213; UBQ; 2.
DR   PROSITE; PS50053; UBIQUITIN_2; 2.
DR   HOGENOMDNA; MOUSE4.PE3752; -.
KW   ENSMUSG000000356925old_1320000031; ENSMUSP000000825481old_1320000031;
KW   Q4FJR9_MOUSE; BC031424; BC083156; BC109346; CH466594; CT010333; U58202;
KW   X56602;
KW   Antiviral defense; Complete proteome; Cytoplasm;
KW   Direct protein sequencing; Isopeptide bond; Reference proteome;
KW   Repeat; Secreted; Ubl conjugation pathway.
SQ   SEQUENCE   161 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAWDLKVKML GGNDFLVSVT NSMTVSELKK QIAQKIGVPA FQQRLAHQTA VLQDGLTLSS
     LGLGPSSTVM LVVQNCSEPL SILVRNERGH SNIYEVFLTQ TVDTLKKKVS QREQVHEDQF
     WLSFEGRPME DKELLGEYGL KPQCTVIKHL RLRGGGGDQC A
//

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