(data stored in ACNUC29543 zone)

HOGENOM: MOUSE5_PE1980

ID   MOUSE5_PE1980                        STANDARD;      PRT;   239 AA.
AC   MOUSE5_PE1980; Q6P6J4; Q8C591;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2;
DE   EC=1.14.11 -;AltName: Full=Alkylated DNA repair protein alkB homolog 2;
DE   (MOUSE5.PE1980).
GN   Name=Alkbh2; Synonyms=Abh2;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE5.PE1980.
CC       Mus musculus chromosome 5 NCBIM37  sequence 1..152537259 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ALKB2_MOUSE
CC   -!- FUNCTION: Dioxygenase that repairs alkylated DNA and RNA
CC       containing 1-methyladenine and 3-methylcytosine by oxidative
CC       demethylation. Can also repair alkylated DNA containing 1-
CC       ethenoadenine. Has strong preference for double-stranded DNA. Has
CC       low efficiency with single-stranded substrates. Requires molecular
CC       oxygen, alpha-ketoglutarate and iron.
CC   -!- COFACTOR: Binds 1 Fe(2+) ion per subunit.
CC   -!- ENZYME REGULATION: Activated by magnesium ions.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Detected in liver, testis and kidney (at
CC       protein level). Detected in heart and testis.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype, and no effect on the
CC       level of 1-ethenoadenine in genomic DNA in aging mice. In
CC       contrast, the levels of 1-methyladenine in genomic DNA increase
CC       over time in aging adults.
CC   -!- SIMILARITY: Belongs to the alkB family.
CC   -!- SIMILARITY: Contains 1 Fe2OG dioxygenase domain.
CC   -!- GENE_FAMILY: HOG000207105 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000044339;ENSMUST00000053657;ENSMUSP00000056043.
DR   EMBL; AK079195; - ;
DR   EMBL; BC062188; - ;
DR   UniProtKB/Swiss-Prot; Q6P6J4; Q8C591; -.
DR   EMBL; AK079195; BAC37576.1; -; mRNA.
DR   EMBL; BC062188; AAH62188.1; -; mRNA.
DR   IPI; IPI00420387; -.
DR   RefSeq; NP_778181.2; NM_175016.2.
DR   UniGene; Mm.332593; -.
DR   ProteinModelPortal; Q6P6J4; -.
DR   SMR; Q6P6J4; 35-235.
DR   PRIDE; Q6P6J4; -.
DR   Ensembl; ENSMUST00000053657; ENSMUSP00000056043; ENSMUSG00000044339.
DR   Ensembl; ENSMUST00000112279; ENSMUSP00000107898; ENSMUSG00000044339.
DR   GeneID; 231642; -.
DR   KEGG; mmu:231642; -.
DR   UCSC; uc008yzd.1; mouse.
DR   CTD; 121642; -.
DR   MGI; MGI:2141032; Alkbh2.
DR   eggNOG; roNOG16318; -.
DR   GeneTree; ENSGT00530000063618; -.
DR   InParanoid; Q6P6J4; -.
DR   OMA; HRDDEKE; -.
DR   OrthoDB; EOG4N8R5T; -.
DR   PhylomeDB; Q6P6J4; -.
DR   NextBio; 380677; -.
DR   ArrayExpress; Q6P6J4; -.
DR   Bgee; Q6P6J4; -.
DR   CleanEx; MM_ALKBH2; -.
DR   Genevestigator; Q6P6J4; -.
DR   GermOnline; ENSMUSG00000044339; Mus musculus.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0010302; F:2-oxoglutarate-dependent dioxygenase activity; IDA:MGI.
DR   GO; GO:0051747; F:cytosine C-5 DNA demethylase activity; ISS:UniProtKB.
DR   GO; GO:0043734; F:DNA-N1-methyladenine dioxygenase activity; ISS:UniProtKB.
DR   GO; GO:0008198; F:ferrous iron binding; ISS:UniProtKB.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporDR   GO; GO:0006307; P:DNA dealkylation involved in DNA repair; ISS:UniProtKB.
DR   GO; GO:0006307; P:DNA dealkylation involved in DNA repair; ISS:UniProtKB.
DR   GO; GO:0035511; P:oxidative DNA demethylation; ISS:UniProtKB.
DR   InterPro; IPR005123; Oxoglutarate/Fe-dep_oxygenase.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
DR   HOGENOMDNA; MOUSE5.PE1980; -.
KW   ENSMUSG000000443395old_1320000031; ENSMUSP000000560431old_1320000031;
KW   AK079195; BC062188;
KW   Complete proteome; Dioxygenase; DNA damage; DNA repair; Iron;
KW   Magnesium; Metal-binding; Nucleus; Oxidoreductase; Reference proteome.
SQ   SEQUENCE   239 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDKFLVRPDL RDLQGGGEEP APTGGASGDL KSPDWRHLRA EGLSCDYTVL FGKAEADKIF
     RELEQEVEYF TGALAKVQVF GKWHSVPRKQ ATYGDAGLTY TFSGLTLTPK PWVPVLERVR
     DRVCEVTGQT FNFVLVNRYK DGCDHIGEHR DDERELAPGS PIASVSFGAC RDFIFRHKDS
     RGKRPRRTVE VVRLQLAHGS LLMMNPPTNT HWYHSLPIRK RVLAPRVNLT FRKILPTKK
//

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