Back to PBIL home page
ID MOUSE5_PE982 STANDARD; PRT; 191 AA.
AC MOUSE5_PE982; Q9D3G9;
DT 00-JAN-0000 (Rel. 1, Created)
DT 00-JAN-0000 (Rel. 2, Last sequence update)
DT 00-JAN-0000 (Rel. 3, Last annotation update)
DE RecName: Full=Rho-related GTP-binding protein RhoH;Flags: Precursor;
DE (MOUSE5.PE982).
GN Name=Rhoh; Synonyms=Arhh;
OS MUS MUSCULUS.
OC Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC Murinae; Mus.
OX NCBI_TaxID=10090;
RN [0]
RP -.;
RG -.;
RL -.;
CC -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE5.PE982.
CC Mus musculus chromosome 5 NCBIM37 sequence 1..152537259 annotated by
CC Ensembl
CC -!- ANNOTATIONS ORIGIN:RHOH_MOUSE
CC -!- FUNCTION: Binds GTP but lacks intrinsic GTPase activity and is
CC resistant to Rho-specific GTPase-activating proteins. Inhibits the
CC activation of NF-kappa-B by TNF and IKKB and the activation of
CC CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42.
CC Negatively regulates leukotriene production in neutrophils (By
CC similarity). Negative regulator of hematopoietic progenitor cell
CC proliferation, survival and migration. Critical regulator of
CC thymocyte development and T-cell antigen receptor (TCR) signaling
CC by mediating recruitment and activation of ZAP70. Required for
CC phosphorylation of CD3Z, membrane translocation of ZAP70 and
CC subsequent activation of the ZAP70-mediated pathways. Essential
CC for efficient beta-selection and positive selection by promoting
CC the ZAP70-dependent phosphorylation of the LAT signalosome during
CC pre-TCR and TCR signaling. Crucial for thymocyte maturation during
CC DN3 to DN4 transition and during positive selection. Plays
CC critical roles in mast cell function by facilitating
CC phosphorylation of SYK in Fc epsilon RI-mediated signal
CC transduction. Essential for the phosphorylation of LAT, LCP2,
CC PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells.
CC -!- SUBUNIT: Interacts with GDI1 and GDI2 (By similarity). Interacts
CC with ZAP70 (via SH2 domains) and the interaction is enhanced by
CC its phosphorylation by LCK. Interacts with SYK and the interaction
CC is enhanced by its phosphorylation by FYN.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Lipid-anchor;
CC Cytoplasmic side. Note=Co-localizes together with ZAP70 in the
CC immunological synapse.
CC -!- TISSUE SPECIFICITY: Expression is widespread in hematopoietic
CC cells, including in bone marrow progenitor cells and in
CC differentiated myeloid as well as lymphoid cells. Expressed at
CC high levels in the thymus and mast cells, found in spleen and low-
CC density bone marrow (LDBM) cells and is detected at a low level in
CC neutrophils. In the thymus it is detected in thymocytes of the
CC thymic cortex but not in nonlymphoid cells of fibrovascular and
CC fibroadipose tissues. Expressed in T-cells, B-cells and mast
CC cells.
CC -!- DEVELOPMENTAL STAGE: Expressed at all stages of thymocyte
CC development, with relative peaks at the DN3 and DP stages.
CC -!- DOMAIN: The region involved in interaction with ZAP70 is a non-
CC canonical immunoreceptor tyrosine-based activation motif (ITAM).
CC -!- PTM: Phosphorylated on tyrosine by LCK. Phosphorylated by FYN.
CC Phosphorylation enhances the interactions with ZAP70 and SYK and
CC is critical for its function in thymocyte development.
CC -!- DISRUPTION PHENOTYPE: Mice show impaired passive systemic
CC anaphylaxis and histamine release upon challenge with the specific
CC antigen and impaired T-cell differentiation.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC -!- GENE_FAMILY: HOG000233974 [ FAMILY / ALN / TREE ]
DR HOGENOM:Mus_musculus;ENSMUSG00000029204;ENSMUST00000031106;ENSMUSP00000031106.
DR EMBL; AK017885; - ;
DR EMBL; AK137909; - ;
DR EMBL; AK138090; - ;
DR EMBL; AK169618; - ;
DR EMBL; BC094937; - ;
DR EMBL; CH466524; - ;
DR UniProtKB/Swiss-Prot; Q9D3G9; -.
DR EMBL; AK017885; BAB30987.1; -; mRNA.
DR IPI; IPI00135993; -.
DR RefSeq; NP_001074574.1; NM_001081105.1.
DR UniGene; Mm.20323; -.
DR ProteinModelPortal; Q9D3G9; -.
DR SMR; Q9D3G9; 2-179.
DR STRING; Q9D3G9; -.
DR PRIDE; Q9D3G9; -.
DR Ensembl; ENSMUST00000031106; ENSMUSP00000031106; ENSMUSG00000029204.
DR GeneID; 74734; -.
DR KEGG; mmu:74734; -.
DR CTD; 399; -.
DR MGI; MGI:1921984; Rhoh.
DR GeneTree; ENSGT00560000076971; -.
DR InParanoid; Q9D3G9; -.
DR OMA; ASCINAI; -.
DR OrthoDB; EOG412M6J; -.
DR PhylomeDB; Q9D3G9; -.
DR NextBio; 341522; -.
DR ArrayExpress; Q9D3G9; -.
DR Bgee; Q9D3G9; -.
DR CleanEx; MM_RHOH; -.
DR Genevestigator; Q9D3G9; -.
DR GermOnline; ENSMUSG00000029204; Mus musculus.
DR GO; GO:0001772; C:immunological synapse; IDA:UniProtKB.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR GO; GO:0045576; P:mast cell activation; IDA:UniProtKB.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR GO; GO:0030217; P:T cell differentiation; IDA:UniProtKB.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00174; RHO; 1.
DR TIGRFAMs; TIGR00231; Small_GTP; 1.
DR PROSITE; PS51420; RHO; 1.
DR HOGENOMDNA; MOUSE5.PE982; -.
KW ENSMUSG000000292045old_1320000031; ENSMUSP000000311061old_1320000031;
KW Q3TEI3_MOUSE; Q504M6_MOUSE; AK017885; AK137909; AK138090; AK169618;
KW CH466524;
KW Cell membrane; Complete proteome; Cytoplasm; GTP-binding; Lipoprotein;
KW Membrane; Methylation; Nucleotide-binding; Phosphoprotein;
KW Prenylation; Reference proteome.
SQ SEQUENCE 191 AA; UNKNOWN MW; UNKNOWN CRC64;
MLSSIKCVLV GDSAVGKTSL LVRFTSETFP EAYKPTVYEN TGVDVFMDGI QISLGLWDTA
GNDAFRSIRP LSYQQADVVL MCYSVANHNS FLNLKNKWIS EIRSNLPCTP VLVVATQTDQ
REVGPHRASC INAIEGKRLA QDVRAKGYLE CSALSNRGVQ QVFECAVRTA VNQARRRNRR
KLFSINECKI F
//
Back to PBIL home page