(data stored in ACNUC31108 zone)

HOGENOM: MOUSE6_PE2170

ID   MOUSE6_PE2170                        STANDARD;      PRT;   226 AA.
AC   MOUSE6_PE2170; P40240; Q3U9W0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=CD9 antigen;AltName: CD_antigen=CD9; (MOUSE6.PE2170).
GN   Name=Cd9;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE6.PE2170.
CC       Mus musculus chromosome 6 NCBIM37  sequence 1..149517037 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CD9_MOUSE
CC   -!- FUNCTION: Involved in platelet activation and aggregation.
CC       Regulates paranodal junction formation. Involved in cell adhesion,
CC       cell motility and tumor metastasis. Required for sperm-egg fusion
CC       (By similarity). Acts as a receptor for PSG17.
CC   -!- SUBUNIT: Forms both disulfide-linked homodimers and higher
CC       homooligomers as well as heterooligomers with other members of the
CC       tetraspanin family. Associates with CR2/CD21 and with
CC       PTGFRN/CD9P1. Interacts directly with IGSF8 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in the peripheral
CC       nervous system.
CC   -!- PTM: Phosphorylated on tyrosine following B-cell activation (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000030342;ENSMUST00000032492;ENSMUSP00000032492.
DR   EMBL; AK002251; - ;
DR   EMBL; AK012793; - ;
DR   EMBL; AK151443; - ;
DR   EMBL; AK151619; - ;
DR   EMBL; AK170310; - ;
DR   EMBL; BC070474; - ;
DR   EMBL; L08115; - ;
DR   UniProtKB/Swiss-Prot; P40240; Q3U9W0; -.
DR   EMBL; L08115; AAA37405.1; -; mRNA.
DR   EMBL; AK002251; BAB21965.1; -; mRNA.
DR   EMBL; AK012793; BAB28473.1; -; mRNA.
DR   EMBL; AK151443; BAE30405.1; -; mRNA.
DR   EMBL; AK151619; BAE30556.1; -; mRNA.
DR   EMBL; AK170310; BAE41707.1; -; mRNA.
DR   EMBL; BC070474; AAH70474.1; -; mRNA.
DR   IPI; IPI00221921; -.
DR   PIR; I49589; I49589.
DR   RefSeq; NP_031683.1; NM_007657.3.
DR   UniGene; Mm.210676; -.
DR   UniGene; Mm.404614; -.
DR   ProteinModelPortal; P40240; -.
DR   SMR; P40240; 109-189.
DR   STRING; P40240; -.
DR   PRIDE; P40240; -.
DR   Ensembl; ENSMUST00000032492; ENSMUSP00000032492; ENSMUSG00000030342.
DR   GeneID; 12527; -.
DR   KEGG; mmu:12527; -.
DR   UCSC; uc009dun.1; mouse.
DR   CTD; 928; -.
DR   MGI; MGI:88348; Cd9.
DR   eggNOG; roNOG08947; -.
DR   GeneTree; ENSGT00590000082836; -.
DR   InParanoid; P40240; -.
DR   OMA; DICPKKD; -.
DR   OrthoDB; EOG402WT9; -.
DR   PhylomeDB; P40240; -.
DR   NextBio; 281554; -.
DR   ArrayExpress; P40240; -.
DR   Bgee; P40240; -.
DR   CleanEx; MM_CD9; -.
DR   Genevestigator; P40240; -.
DR   GermOnline; ENSMUSG00000030342; Mus musculus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; ISS:UniProtKB.
DR   GO; GO:0006928; P:cellular component movement; ISS:UniProtKB.
DR   GO; GO:0007342; P:fusion of sperm to egg plasma membrane; IDA:UniProtKB.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IDA:MGI.
DR   GO; GO:0030913; P:paranodal junction assembly; IDA:UniProtKB.
DR   InterPro; IPR023396; CD81_extracellular.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Gene3D; G3DSA:1.10.1450.10; G3DSA:1.10.1450.10; 1.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; MOUSE6.PE2170; -.
KW   ENSMUSG000000303425old_1320000031; ENSMUSP000000324921old_1320000031;
KW   AK002251; AK012793; AK151443; AK151619; AK170310; BC070474; L08115;
KW   Cell adhesion; Complete proteome; Disulfide bond; Fertilization;
KW   Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   226 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPVKGGSKCI KYLLFGFNFI FWLAGIAVLA IGLWLRFDSQ TKSIFEQENN HSSFYTGVYI
     LIGAGALMML VGFLGCCGAV QESQCMLGLF FGFLLVIFAI EIAAAVWGYT HKDEVIKELQ
     EFYKDTYQKL RSKDEPQRET LKAIHMALDC CGIAGPLEQF ISDTCPKKQL LESFQVKPCP
     EAISEVFNNK FHIIGAVGIG IAVVMIFGMI FSMILCCAIR RSREMV
//

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