(data stored in ACNUC15468 zone)

HOGENOM: MOUSE6_PE615

ID   MOUSE6_PE615                         STANDARD;      PRT;   994 AA.
AC   MOUSE6_PE615; Q64347; Q8BZ41; Q9QVY5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Chloride channel protein 1; Short=ClC-1;AltName:
DE   Full=Chloride channel protein, skeletal muscle; (MOUSE6.PE615).
GN   Name=Clcn1; Synonyms=Clc1;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE6.PE615.
CC       Mus musculus chromosome 6 NCBIM37  sequence 1..149517037 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CLCN1_MOUSE
CC   -!- FUNCTION: Voltage-gated chloride channel. Chloride channels have
CC       several functions including the regulation of cell volume;
CC       membrane potential stabilization, signal transduction and
CC       transepithelial transport.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in skeletal muscles.
CC   -!- MISCELLANEOUS: The CLC channel family contains both chloride
CC       channels and proton-coupled anion transporters that exchange
CC       chloride or another anion for protons. The absence of conserved
CC       gating glutamate residues is typical for family members that
CC       function as channels (By similarity).
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       ClC-1/CLCN1 subfamily.
CC   -!- SIMILARITY: Contains 2 CBS domains.
CC   -!- GENE_FAMILY: HOG000231297 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000029862;ENSMUST00000031894;ENSMUSP00000031894.
DR   EMBL; AK036735; - ;
DR   EMBL; AY046403; - ;
DR   EMBL; BC114336; - ;
DR   EMBL; CH466533; - ;
DR   EMBL; X62895; - ;
DR   EMBL; X62896; - ;
DR   EMBL; X62897; - ;
DR   EMBL; Z95127; - ;
DR   EMBL; Z95128; - ;
DR   EMBL; Z95129; - ;
DR   EMBL; Z95130; - ;
DR   EMBL; Z95131; - ;
DR   EMBL; Z95132; - ;
DR   EMBL; Z95133; - ;
DR   EMBL; Z95134; - ;
DR   EMBL; Z95135; - ;
DR   EMBL; Z95136; - ;
DR   EMBL; Z95137; - ;
DR   EMBL; Z95138; - ;
DR   EMBL; Z95139; - ;
DR   EMBL; Z95140; - ;
DR   EMBL; Z95141; - ;
DR   EMBL; Z95142; - ;
DR   EMBL; Z95143; - ;
DR   EMBL; Z95144; - ;
DR   EMBL; Z95145; - ;
DR   EMBL; Z95146; - ;
DR   EMBL; Z95147; - ;
DR   EMBL; Z95148; - ;
DR   EMBL; Z95149; - ;
DR   UniProtKB/Swiss-Prot; Q64347; Q8BZ41; Q9QVY5; -.
DR   EMBL; Z95127; CAB08359.1; -; Genomic_DNA.
DR   EMBL; Z95128; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95129; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95130; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95131; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95132; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95133; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95134; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95135; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95136; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95137; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95138; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95139; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95140; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95141; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95142; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95143; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95144; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95145; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95146; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95147; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95148; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; Z95149; CAB08359.1; JOINED; Genomic_DNA.
DR   EMBL; AK036735; BAC29557.1; -; mRNA.
DR   EMBL; CH466533; EDL13488.1; -; Genomic_DNA.
DR   EMBL; BC114336; AAI14337.1; -; mRNA.
DR   EMBL; X62895; CAA44684.1; -; mRNA.
DR   EMBL; X62896; CAA44685.1; -; mRNA.
DR   EMBL; X62897; CAA44686.1; -; mRNA.
DR   IPI; IPI00133420; -.
DR   PIR; I48773; I48773.
DR   RefSeq; NP_038519.1; NM_013491.2.
DR   UniGene; Mm.386757; -.
DR   ProteinModelPortal; Q64347; -.
DR   SMR; Q64347; 114-878.
DR   STRING; Q64347; -.
DR   PhosphoSite; Q64347; -.
DR   PRIDE; Q64347; -.
DR   Ensembl; ENSMUST00000031894; ENSMUSP00000031894; ENSMUSG00000029862.
DR   GeneID; 12723; -.
DR   KEGG; mmu:12723; -.
DR   UCSC; uc009bqs.1; mouse.
DR   CTD; 1180; -.
DR   MGI; MGI:88417; Clcn1.
DR   InParanoid; Q64347; -.
DR   OMA; FQSLLHC; -.
DR   OrthoDB; EOG4VT5WG; -.
DR   PhylomeDB; Q64347; -.
DR   ArrayExpress; Q64347; -.
DR   Bgee; Q64347; -.
DR   CleanEx; MM_CLCN1; -.
DR   Genevestigator; Q64347; -.
DR   GermOnline; ENSMUSG00000029862; Mus musculus.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0042383; C:sarcolemma; IDA:MGI.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   GO; GO:0019227; P:neuronal action potential propagation; IMP:MGI.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002243; Cl_channel-1.
DR   InterPro; IPR000644; Cysta_beta_synth_core.
DR   Gene3D; G3DSA:1.10.3080.10; Cl-channel_core; 1.
DR   PANTHER; PTHR11689; Cl-channel_volt; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01112; CLCHANNEL1.
DR   SUPFAM; SSF81340; Cl-channel_core; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   HOGENOMDNA; MOUSE6.PE615; -.
KW   ENSMUSG000000298625old_1320000031; ENSMUSP000000318941old_1320000031;
KW   Q8K3N1_MOUSE; AK036735; AY046403; BC114336; CH466533; X62895; X62896;
KW   Z95127; Z95128; Z95129; Z95130; Z95131; Z95132; Z95133; Z95134; Z95135;
KW   Z95137; Z95138; Z95139; Z95140; Z95141; Z95142; Z95143; Z95144; Z95145;
KW   Z95147; Z95148; Z95149;
KW   CBS domain; Chloride; Chloride channel; Complete proteome;
KW   Ion transport; Ionic channel; Membrane; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
SQ   SEQUENCE   994 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MERSQSQRHG GEQSWWGSAP QYQYMPFEHC TSYGLPSENG GLQHRPRKDM GPRHNAHPTQ
     IYGHQKEQYS YKAQDGGMPK KMGSSSTMDS LDEDHYSKCQ DCVHRLGRVL RRKLGEDWIF
     LVLLGLLMAL VSWCMDYVSA KSLQAYKWTY AQMKPSLPLQ YLAWVTFPLI LILFSALFCQ
     LISPQAVGSG IPEMKTILRG VVLKEYLTLK AFVAKVVALT AGLGSGIPVG KEGPFVHIAS
     ICAAVLSKFM SMFSGVYEQP YYYTDILTVG CAVGVGCCFG TPLGGVLFSI EVTSTYFAVR
     NYWRGFFAAT FSAFVFRVLA VWNKDAVTIT ALFRTNFRMD FPFDLKELPA FAVIGICCGF
     LGAVFVYLHR QVMLGVRKHK CLSQFLAKHR LLYPGIVTFV IASLTFPPGM GQFMAGELMP
     REAISTLFDN NTWVKHIGDP QSLGQSAVWL HPQVNVIIII LLFFVMKFWM SIVATTMPIP
     CGGFMPVFVL GAAFGRLVGE IMAMLFPEGI LFDDIIYKIL PGGYAVIGAA ALTGAVSHTV
     STAVICFELT GQIAHILPMM VAVILANMVA QSLQPSLYDS IIQVKKLPYL PDLGWNQLSK
     FTIFVEDIMV RDVKFVSASC TYGELRNLLQ ATTVKTLPLV DSKDSMILLG SVERSELQSL
     LQRHLCAERR LKAAQDMARK LSELPYNGKA QLAGDWHPGG RPESFAFVDE DEDEDLSRKM
     ELPLTPAPPP PSPPPPPSQF PIAPSNPEEP NGPLPSHKQP PEASDSADQR SSTFQRLLHC
     LLGKAHSKKK KITQDSTDLV DNMSPEEIEA WEREQLSQPV CFDCCCIDQS PFQLVEQTTL
     HKTHTLFSLL GLHLAYVTSM GKLRGVLALE ELQKAIEGHT KSGVQLRPPL ASFRNTTSIR
     KTPGGPPPPA EGWNVPEDGD GAPGREVMVP TMPETPVPPP SPEAPSCLAP ARAEGELEEL
     EMVGSLEPEE ELADILHGPS LRSTDEEDED ELIL
//

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