(data stored in ACNUC10243 zone)

HOGENOM: MOUSE6_PE784

ID   MOUSE6_PE784                         STANDARD;      PRT;   372 AA.
AC   MOUSE6_PE784;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Heterogeneous nuclear ribonucleoproteins A2/B1; Short=hnRNP
DE   A2/B1; (MOUSE6.PE784).
GN   Name=Hnrnpa2b1; Synonyms=Hnrpa2b1;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE6.PE784.
CC       Mus musculus chromosome 6 NCBIM37  sequence 1..149517037 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ROA2_MOUSE
CC   -!- FUNCTION: Involved with pre-mRNA processing. Forms complexes
CC       (ribonucleosomes) with at least 20 other different hnRNP and
CC       heterogeneous nuclear RNA in the nucleous (By similarity).
CC   -!- SUBUNIT: Identified in the spliceosome C complex. Identified in a
CC       mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG,
CC       HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU,
CC       HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4,
CC       PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2,
CC       YBX1 and untranslated mRNAs. Interacts with IGF2BP1 (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm (By
CC       similarity). Note=Localized in cytoplasmic mRNP granules
CC       containing untranslated mRNAs (By similarity). Component of
CC       ribonucleosomes. Predominantly nucleoplasmic, however isoform 2 is
CC       also found in the cytoplasm of cells in some tissues. Not found in
CC       the nucleolus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=B1;
CC         IsoId=O88569-1; Sequence=Displayed;
CC       Name=2; Synonyms=A2;
CC         IsoId=O88569-2; Sequence=VSP_022595;
CC       Name=3;
CC         IsoId=O88569-3; Sequence=VSP_022595, VSP_025012;
CC   -!- SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
CC   -!- GENE_FAMILY: HOG000234442 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000004980;ENSMUST00000069949;ENSMUSP00000067491.
DR   EMBL; AF073990; - ;
DR   EMBL; AF073993; - ;
DR   EMBL; AF406651; - ;
DR   EMBL; AF452567; - ;
DR   EMBL; AK089012; - ;
DR   EMBL; AK137214; - ;
DR   EMBL; BC059107; - ;
DR   EMBL; BC141253; - ;
DR   UniProtKB/Swiss-Prot; O88569; B9EJ02; Q3UVJ5; Q6PCV9; Q8C2A0; Q8CJ71; Q91ZR9; Q9R204; -.
DR   EMBL; AF406651; AAK98601.2; -; mRNA.
DR   EMBL; AF452567; AAN16352.1; -; Genomic_DNA.
DR   EMBL; AF073990; AAD29846.1; -; Genomic_DNA.
DR   EMBL; AF073993; AAC26867.1; -; mRNA.
DR   EMBL; AK089012; BAC40700.1; -; mRNA.
DR   EMBL; AK137214; BAE23274.1; -; mRNA.
DR   EMBL; BC059107; AAH59107.1; -; mRNA.
DR   EMBL; BC141253; AAI41254.1; -; mRNA.
DR   IPI; IPI00405058; -.
DR   IPI; IPI00622847; -.
DR   IPI; IPI00828488; -.
DR   RefSeq; NP_058086.2; NM_016806.2.
DR   RefSeq; NP_872591.1; NM_182650.3.
DR   RefSeq; XP_001473875.2; XM_001473825.2.
DR   UniGene; Mm.155896; -.
DR   ProteinModelPortal; O88569; -.
DR   SMR; O88569; 1-195.
DR   IntAct; O88569; 4.
DR   STRING; O88569; -.
DR   PhosphoSite; O88569; -.
DR   SWISS-2DPAGE; O88569; -.
DR   REPRODUCTION-2DPAGE; IPI00405058; -.
DR   REPRODUCTION-2DPAGE; O88569; -.
DR   PRIDE; O88569; -.
DR   Ensembl; ENSMUST00000069949; ENSMUSP00000067491; ENSMUSG00000004980.
DR   Ensembl; ENSMUST00000114459; ENSMUSP00000110103; ENSMUSG00000004980.
DR   GeneID; 100045191; -.
DR   GeneID; 53379; -.
DR   KEGG; mmu:100045191; -.
DR   KEGG; mmu:53379; -.
DR   UCSC; uc009bxm.1; mouse.
DR   UCSC; uc009bxn.1; mouse.
DR   CTD; 3181; -.
DR   MGI; MGI:104819; Hnrnpa2b1.
DR   eggNOG; roNOG06874; -.
DR   GeneTree; ENSGT00540000069937; -.
DR   OrthoDB; EOG4HQDKF; -.
DR   NextBio; 310199; -.
DR   ArrayExpress; O88569; -.
DR   Bgee; O88569; -.
DR   CleanEx; MM_HNRNPA2B1; -.
DR   Genevestigator; O88569; -.
DR   GermOnline; ENSMUSG00000004980; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030530; C:heterogeneous nuclear ribonucleoprotein complex; ISS:HGNC.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; ISS:HGNC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0003723; F:RNA binding; ISS:HGNC.
DR   GO; GO:0043047; F:single-stranded telomeric DNA binding; ISS:HGNC.
DR   GO; GO:0006397; P:mRNA processing; ISS:HGNC.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   GO; GO:0050658; P:RNA transport; ISS:HGNC.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR   InterPro; IPR000504; RRM_dom.
DR   Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   PROSITE; PS50102; RRM; 2.
DR   HOGENOMDNA; MOUSE6.PE784; -.
KW   ENSMUSG000000049805old_1320000031; ENSMUSP000000674911old_1320000031;
KW   AF073990; AF073993; AF406651; AF452567; AK089012; AK137214; BC059107;
KW   BC141253;
KW   Acetylation; Alternative splicing; Complete proteome; Cytoplasm;
KW   Direct protein sequencing; Methylation; mRNA processing;
KW   mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
SQ   SEQUENCE   372 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     WGEGSRKAAV SAPAAVAAAP VPCAGAPLRP SFLAIACSPH SARTSPVRVR PRRSFSSRSA
     AGNRAEATES AMEREKEQFR KLFIGGLSFE TTEESLRNYY EQWGKLTDCV VMRDPASKRS
     RGFGFVTFSS MAEVDAAMAA RPHSIDGRVV EPKRAVAREE SGKPGAHVTV KKLFVGGIKE
     DTEEHHLRDY FEEYGKIDTI EIITDRQSGK KRGFGFVTFD DHDPVDKIVL QKYHTINGHN
     AEVRKALSRQ EMQEVQSSRS GRGGNFGFGD SRGGGGNFGP GPGSNFRGGS DGYGSGRGFG
     DGYNGYGGGP GGNYGSGSYN DFGNYNQQPS NYGPMKSGNF GGSRNMGGPY GGGNYGPGGS
     GGSGGYGGRS RY
//

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