(data stored in ACNUC10243 zone)

HOGENOM: MOUSE6_PE785

ID   MOUSE6_PE785                         STANDARD;      PRT;   341 AA.
AC   MOUSE6_PE785;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Heterogeneous nuclear ribonucleoproteins A2/B1; Short=hnRNP
DE   A2/B1; (MOUSE6.PE785).
GN   Name=Hnrnpa2b1; Synonyms=Hnrpa2b1;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE6.PE785.
CC       Mus musculus chromosome 6 NCBIM37  sequence 1..149517037 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ROA2_MOUSE
CC   -!- FUNCTION: Involved with pre-mRNA processing. Forms complexes
CC       (ribonucleosomes) with at least 20 other different hnRNP and
CC       heterogeneous nuclear RNA in the nucleous (By similarity).
CC   -!- SUBUNIT: Identified in the spliceosome C complex. Identified in a
CC       mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG,
CC       HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU,
CC       HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4,
CC       PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2,
CC       YBX1 and untranslated mRNAs. Interacts with IGF2BP1 (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm (By
CC       similarity). Note=Localized in cytoplasmic mRNP granules
CC       containing untranslated mRNAs (By similarity). Component of
CC       ribonucleosomes. Predominantly nucleoplasmic, however isoform 2 is
CC       also found in the cytoplasm of cells in some tissues. Not found in
CC       the nucleolus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=B1;
CC         IsoId=O88569-1; Sequence=Displayed;
CC       Name=2; Synonyms=A2;
CC         IsoId=O88569-2; Sequence=VSP_022595;
CC       Name=3;
CC         IsoId=O88569-3; Sequence=VSP_022595, VSP_025012;
CC   -!- SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
CC   -!- GENE_FAMILY: HOG000234442 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000004980;ENSMUST00000116609;ENSMUSP00000112308.
DR   EMBL; AF073990; - ;
DR   EMBL; AF073993; - ;
DR   EMBL; AF406651; - ;
DR   EMBL; AF452567; - ;
DR   EMBL; AK089012; - ;
DR   EMBL; AK137214; - ;
DR   EMBL; BC059107; - ;
DR   EMBL; BC141253; - ;
DR   EMBL; BC145588; - ;
DR   UniProtKB/Swiss-Prot; O88569; B9EJ02; Q3UVJ5; Q6PCV9; Q8C2A0; Q8CJ71; Q91ZR9; Q9R204; -.
DR   EMBL; AF406651; AAK98601.2; -; mRNA.
DR   EMBL; AF452567; AAN16352.1; -; Genomic_DNA.
DR   EMBL; AF073990; AAD29846.1; -; Genomic_DNA.
DR   EMBL; AF073993; AAC26867.1; -; mRNA.
DR   EMBL; AK089012; BAC40700.1; -; mRNA.
DR   EMBL; AK137214; BAE23274.1; -; mRNA.
DR   EMBL; BC059107; AAH59107.1; -; mRNA.
DR   EMBL; BC141253; AAI41254.1; -; mRNA.
DR   IPI; IPI00405058; -.
DR   IPI; IPI00622847; -.
DR   IPI; IPI00828488; -.
DR   RefSeq; NP_058086.2; NM_016806.2.
DR   RefSeq; NP_872591.1; NM_182650.3.
DR   RefSeq; XP_001473875.2; XM_001473825.2.
DR   UniGene; Mm.155896; -.
DR   ProteinModelPortal; O88569; -.
DR   SMR; O88569; 1-195.
DR   IntAct; O88569; 4.
DR   STRING; O88569; -.
DR   PhosphoSite; O88569; -.
DR   SWISS-2DPAGE; O88569; -.
DR   REPRODUCTION-2DPAGE; IPI00405058; -.
DR   REPRODUCTION-2DPAGE; O88569; -.
DR   PRIDE; O88569; -.
DR   Ensembl; ENSMUST00000069949; ENSMUSP00000067491; ENSMUSG00000004980.
DR   Ensembl; ENSMUST00000114459; ENSMUSP00000110103; ENSMUSG00000004980.
DR   GeneID; 100045191; -.
DR   GeneID; 53379; -.
DR   KEGG; mmu:100045191; -.
DR   KEGG; mmu:53379; -.
DR   UCSC; uc009bxm.1; mouse.
DR   UCSC; uc009bxn.1; mouse.
DR   CTD; 3181; -.
DR   MGI; MGI:104819; Hnrnpa2b1.
DR   eggNOG; roNOG06874; -.
DR   GeneTree; ENSGT00540000069937; -.
DR   OrthoDB; EOG4HQDKF; -.
DR   NextBio; 310199; -.
DR   ArrayExpress; O88569; -.
DR   Bgee; O88569; -.
DR   CleanEx; MM_HNRNPA2B1; -.
DR   Genevestigator; O88569; -.
DR   GermOnline; ENSMUSG00000004980; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030530; C:heterogeneous nuclear ribonucleoprotein complex; ISS:HGNC.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; ISS:HGNC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0003723; F:RNA binding; ISS:HGNC.
DR   GO; GO:0043047; F:single-stranded telomeric DNA binding; ISS:HGNC.
DR   GO; GO:0006397; P:mRNA processing; ISS:HGNC.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   GO; GO:0050658; P:RNA transport; ISS:HGNC.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR   InterPro; IPR000504; RRM_dom.
DR   Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   PROSITE; PS50102; RRM; 2.
DR   HOGENOMDNA; MOUSE6.PE785; -.
KW   ENSMUSG000000049805old_1320000031; ENSMUSP000001123081old_1320000031;
KW   B7ZP22_MOUSE; AF073990; AF073993; AF406651; AF452567; AK089012; AK137214;
KW   BC141253; BC145588;
KW   Acetylation; Alternative splicing; Complete proteome; Cytoplasm;
KW   Direct protein sequencing; Methylation; mRNA processing;
KW   mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
SQ   SEQUENCE   341 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEREKEQFRK LFIGGLSFET TEESLRNYYE QWGKLTDCVV MRDPASKRSR GFGFVTFSSM
     AEVDAAMAAR PHSIDGRVVE PKRAVAREES GKPGAHVTVK KLFVGGIKED TEEHHLRDYF
     EEYGKIDTIE IITDRQSGKK RGFGFVTFDD HDPVDKIVLQ KYHTINGHNA EVRKALSRQE
     MQEVQSSRSG RGGNFGFGDS RGGGGNFGPG PGSNFRGGSD GYGSGRGFGD GYNGYGGGPG
     GGNFGGSPGY GGGRGGYGGG GPGYGNQGGG YGGGYDNYGG GNYGSGSYND FGNYNQQPSN
     YGPMKSGNFG GSRNMGGPYG GGNYGPGGSG GSGGYGGRSR Y
//

If you have problems or comments...

PBIL Back to PBIL home page