(data stored in ACNUC30567 zone)

HOGENOM: MOUSE7_PE2317

ID   MOUSE7_PE2317                        STANDARD;      PRT;   150 AA.
AC   MOUSE7_PE2317; Q62264;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Thyroid hormone-inducible hepatic protein;AltName:
DE   Full=Spot 14 protein; Short=S14; Short=SPOT14; (MOUSE7.PE2317).
GN   Name=Thrsp; Synonyms=S14;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE7.PE2317.
CC       Mus musculus chromosome 7 NCBIM37  sequence 1..152524553 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:THRSP_MOUSE
CC   -!- FUNCTION: Plays a role in the regulation of lipogenesis,
CC       especially in lactating mammary gland. Important for the
CC       biosynthesis of triglycerides with medium-length fatty acid
CC       chains. May modulate lipogenesis by interacting with MID1IP1 and
CC       preventing its interaction with ACACA. May function as
CC       transcriptional coactivator. May modulate the transcription factor
CC       activity of THRB (By similarity).
CC   -!- SUBUNIT: Homodimer. Heterodimer with MID1IP1. Interacts with THRB
CC       and PLAGL1 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in tissues that synthesize
CC       triglycerides.
CC   -!- DISRUPTION PHENOTYPE: Decreased lipid synthesis in the lactating
CC       mammary gland. Milk has reduced triglyceride content, causing
CC       reduced weight gain in nursing pups. Adults exhibit reduced body
CC       fat content. No effect on lipid synthesis in liver. No effect on
CC       the expression of thyroid hormone-induced lipogenic genes.
CC   -!- SIMILARITY: Belongs to the SPOT14 family.
CC   -!- GENE_FAMILY: HOG000001157 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000035686;ENSMUST00000043077;ENSMUSP00000042988.
DR   EMBL; AK050300; - ;
DR   EMBL; AK077300; - ;
DR   EMBL; BC009165; - ;
DR   EMBL; CH466531; - ;
DR   EMBL; X95279; - ;
DR   UniProtKB/Swiss-Prot; Q62264; -.
DR   EMBL; X95279; CAA64600.1; -; Genomic_DNA.
DR   EMBL; BC009165; AAH09165.1; -; mRNA.
DR   IPI; IPI00123449; -.
DR   RefSeq; NP_033407.1; NM_009381.2.
DR   UniGene; Mm.28585; -.
DR   PDB; 3ONT; X-ray; 2.65 A; A=1-150.
DR   PDBsum; 3ONT; -.
DR   ProteinModelPortal; Q62264; -.
DR   SMR; Q62264; 8-149.
DR   STRING; Q62264; -.
DR   PRIDE; Q62264; -.
DR   Ensembl; ENSMUST00000043077; ENSMUSP00000042988; ENSMUSG00000035686.
DR   GeneID; 21835; -.
DR   KEGG; mmu:21835; -.
DR   CTD; 7069; -.
DR   MGI; MGI:109126; Thrsp.
DR   InParanoid; Q62264; -.
DR   OMA; NMEQVVM; -.
DR   OrthoDB; EOG4V9TS5; -.
DR   PhylomeDB; Q62264; -.
DR   NextBio; 301290; -.
DR   ArrayExpress; Q62264; -.
DR   Bgee; Q62264; -.
DR   Genevestigator; Q62264; -.
DR   GermOnline; ENSMUSG00000035686; Mus musculus.
DR   GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0010866; P:regulation of triglyceride biosynthetic process; IMP:UniProtKB.
DR   GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   InterPro; IPR009786; Spot_14.
DR   PANTHER; PTHR14315; Spot_14; 1.
DR   HOGENOMDNA; MOUSE7.PE2317; -.
KW   ENSMUSG000000356865old_1320000031; ENSMUSP000000429881old_1320000031;
KW   Q543J4_MOUSE; Q8BPB6_MOUSE; AK050300; AK077300; BC009165; CH466531;
KW   X95279;
KW   3D-structure; Complete proteome; Cytoplasm; Lipid synthesis; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
SQ   SEQUENCE   150 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQVLTKRYPK NCLLTVMDRY SAVVRNMEQV VMIPSLLRDV QLSGPGGSVQ DGAPDLYTYF
     TMLKSICVEV DHGLLPREEW QAKVAGNETS EAENDAAETE EAEEDRISEE LDLEAQFHLH
     FCSLHHILTH LTRKAQEVTR KYQEMTGQVL
//

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