(data stored in ACNUC5448 zone)

HOGENOM: MOUSE7_PE2342

ID   MOUSE7_PE2342                        STANDARD;      PRT;   2215 AA.
AC   MOUSE7_PE2342; P97479; E9QLP7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Myosin-VIIa; (MOUSE7.PE2342).
GN   Name=Myo7a; Synonyms=Myo7;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE7.PE2342.
CC       Mus musculus chromosome 7 NCBIM37  sequence 1..152524553 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MYO7A_MOUSE
CC   -!- FUNCTION: Myosins are actin-based motor molecules with ATPase
CC       activity. Unconventional myosins serve in intracellular movements.
CC       Their highly divergent tails are presumed to bind to membranous
CC       compartments, which would be moved relative to actin filaments. In
CC       retina, myosin VIIa might play a role in trafficking of ribbon-
CC       synaptic vesicle complexes and renewal of the outer photoreceptors
CC       disks. In inner ear, it might maintain the rigidity of stereocilia
CC       during the dynamic movements of the bundle. Involved in hair-cell
CC       vesicle trafficking of aminoglycosides, which are known to induce
CC       ototoxicity.
CC   -!- SUBUNIT: Might homodimerize in a two headed molecule through the
CC       formation of a coiled-coil rod (By similarity). Binds MYRIP and
CC       WHRN. Interacts with PLEKHB1 (via PH domain).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- TISSUE SPECIFICITY: Expressed in the retina, cochlea, kidney and
CC       liver.
CC   -!- DEVELOPMENTAL STAGE: In the inner ear of the 16.5 day old embryo,
CC       expressed only in the cochlear and vestibular sensory hair cells.
CC       In addition, expression also occurs in the epithelial cells of the
CC       small intestine, hepatocytes, and choroidal plexus.
CC   -!- DISEASE: Note=Defects in Myo7a are the cause of the shaker-1 (sh-
CC       1) phenotype which affects only the inner ear. Sh-1 homozygote
CC       mutants show hyperactivity, head tossing and circling due to
CC       vestibular dysfunction, together with typical neuroepithelial-type
CC       cochlear defects involving dysfunction and progressive
CC       degeneration of the organ of Corti.
CC   -!- SIMILARITY: Contains 2 FERM domains.
CC   -!- SIMILARITY: Contains 5 IQ domains.
CC   -!- SIMILARITY: Contains 1 myosin head-like domain.
CC   -!- SIMILARITY: Contains 2 MyTH4 domains.
CC   -!- SIMILARITY: Contains 1 SH3 domain.
CC   -!- GENE_FAMILY: HOG000007836 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000030761;ENSMUST00000107128;ENSMUSP00000102745.
DR   EMBL; U81453; - ;
DR   UniProtKB/Swiss-Prot; P97479; E9QLP7; -.
DR   EMBL; U81453; AAB40708.1; -; mRNA.
DR   EMBL; AC115022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC157792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   IPI; IPI00125593; -.
DR   PIR; T30870; T30870.
DR   UniGene; Mm.1403; -.
DR   ProteinModelPortal; P97479; -.
DR   IntAct; P97479; 2.
DR   MINT; MINT-1896820; -.
DR   STRING; P97479; -.
DR   PhosphoSite; P97479; -.
DR   PRIDE; P97479; -.
DR   Ensembl; ENSMUST00000107128; ENSMUSP00000102745; ENSMUSG00000030761.
DR   MGI; MGI:104510; Myo7a.
DR   eggNOG; roNOG10422; -.
DR   GeneTree; ENSGT00600000084203; -.
DR   OrthoDB; EOG4S1T67; -.
DR   PhylomeDB; P97479; -.
DR   ArrayExpress; P97479; -.
DR   Bgee; P97479; -.
DR   CleanEx; MM_MYO7A; -.
DR   Genevestigator; P97479; -.
DR   GermOnline; ENSMUSG00000030761; Mus musculus.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0001917; C:photoreceptor inner segment; ISS:UniProtKB.
DR   GO; GO:0001750; C:photoreceptor outer segment; ISS:UniProtKB.
DR   GO; GO:0045202; C:synapse; IDA:UniProtKB.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005516; F:calmodulin binding; ISS:UniProtKB.
DR   GO; GO:0003774; F:motor activity; IEA:InterPro.
DR   GO; GO:0007040; P:lysosome organization; ISS:UniProtKB.
DR   GO; GO:0007605; P:sensory perception of sound; ISS:UniProtKB.
DR   GO; GO:0007601; P:visual perception; ISS:UniProtKB.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR000857; MyTH4_dom.
DR   InterPro; IPR011993; PH_type.
DR   InterPro; IPR001452; SH3_domain.
DR   Gene3D; G3DSA:1.20.80.10; ACBP; 2.
DR   Gene3D; G3DSA:2.30.29.30; PH_type; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 2.
DR   Pfam; PF00612; IQ; 3.
DR   Pfam; PF00063; Myosin_head; 1.
DR   Pfam; PF00784; MyTH4; 2.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00295; B41; 2.
DR   SMART; SM00015; IQ; 4.
DR   SMART; SM00242; MYSc; 1.
DR   SMART; SM00139; MyTH4; 2.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF47031; FERM_3-hlx; 2.
DR   SUPFAM; SSF50044; SH3; 1.
DR   PROSITE; PS00660; FERM_1; FALSE_NEG.
DR   PROSITE; PS00661; FERM_2; FALSE_NEG.
DR   PROSITE; PS50057; FERM_3; 2.
DR   PROSITE; PS50096; IQ; 3.
DR   PROSITE; PS51016; MYTH4; 2.
DR   PROSITE; PS50002; SH3; 1.
DR   HOGENOMDNA; MOUSE7.PE2342; -.
KW   ENSMUSG000000307615old_1320000031; ENSMUSP000001027451old_1320000031;
KW   U81453;
KW   Actin-binding; ATP-binding; Calmodulin-binding; Coiled coil;
KW   Complete proteome; Cytoplasm; Deafness; Disease mutation; Hearing;
KW   Motor protein; Myosin; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Repeat; SH3 domain.
SQ   SEQUENCE   2215 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MVILQKGDYV WMDLKSGQEF DVPIGAVVKL CDSGQIQVVD DEDNEHWISP QNATHIKPMH
     PTSVHGVEDM IRLGDLNEAG ILRNLLIRYR DHLIYTYTGS ILVAVNPYQL LSIYSPEHIR
     QYTNKKIGEM PPHIFAIADN CYFNMKRNNR DQCCIISGES GAGKTESTKL ILQFLAAISG
     QHSWIEQQVL EATPILEAFG NAKTIRNDNS SRFGKYIDIH FNKRGAIEGA KIEQYLLEKS
     RVCRQAPDER NYHVFYCMLE GMNEEEKKKL GLGQAADYNY LAMGNCITCE GRVDSQEYAN
     IRSAMKVLMF TDTENWEISK LLAAILHMGN LQYEARTFEN LDACEVLFSP SLATAASLLE
     VNPPDLMSCL TSRTLITRGE TVSTPLSREQ ALDVRDAFVK GIYGRLFVWI VEKINAAIYK
     PPPLEVKNSR RSIGLLDIFG FENFTVNSFE QLCINFANEH LQQFFVRHVF KLEQEEYDLE
     SIDWLHIEFT DNQEALDMIA NRPMNVISLI DEESKFPKGT DATMLHKLNS QHKLNANYVP
     PKNSHETQFG INHFAGVVYY ESQGFLEKNR DTLHGDIIQL VHSSRNKFIK QIFQADVAMG
     AETRKRSPTL SSQFKRSLEL LMRTLGACQP FFVRCIKPNE FKKPMLFDRH LCVRQLRYSG
     MMETIRIRHA GYPIRYSFVE FVERYRVLLP GVKPAYKQGD LRGTCQRMAE AVLGTHDDWQ
     IGKTKIFLKD HHDMLLEVER DKAITDRVIL LQKVIRGFKD RSNFLRLKSA ATLIQRHWRG
     HHCRKNYELI RLGFLRLQAL HRSRKLHKQY RLARQRIIEF QARCRAYLVR KAFRHRLWAV
     ITVQAYARGM IARRLHRRLR VEYQRRLEAE RMRLAEEEKL RKEMSAKKAK EEAERKHQER
     LAQLAREDAE RELKEKEEAR RKKELLEQME KARHEPINHS DMVDKMFGFL GTSGSLPGQE
     GQAPSGFEDL ERGRREMVEE DVDAALPLPD EDEEDLSEYK FAKFAATYFQ GTTTHSYTRR
     PLKQPLLYHD DEGDQLAALA VWITILRFMG DLPEPKYHTA MSDGSEKIPV MTKIYETLGK
     KTYKRELQAL QGEGETQLPE GQKKTSVRHK LVHLTLKKKS KLTEEVTKRL NDGESTVQGN
     SMLEDRPTSN LEKLHFIIGN GILRPALRDE IYCQISKQLT HNPSKSSYAR GWILVSLCVG
     CFAPSEKFVK YLRNFIHGGP PGYAPYCEER LRRTFVNGTR TQPPSWLELQ ATKSKKPIML
     PVTFMDGTTK TLLTDSATTA RELCNALADK ISLKDRFGFS LYIALFDKVS SLGSGSDHVM
     DAISQCEQYA KEQGAQERNA PWRLFFRKEV FTPWHNPSED NVATNLIYQQ VVRGVKFGEY
     RCEKEDDLAE LASQQYFVDY GSEMILERLL SLVPTYIPDR EITPLKNLEK WAQLAIAAHK
     KGIYAQRRTD SQKVKEDVVN YARFKWPLLF SRFYEAYKFS GPPLPKSDVI VAVNWTGVYF
     VDEQEQVLLE LSFPEIMAVS SSRECRVLLS LGCSDLGCAT CQSGRAGLTP AGPCSPCWSC
     RGTKMMAPSF TLATIKGDEY TFTSSNAEDI RDLVVTFLEG LRKRSKYVVA LQDNPNPAGE
     ESGFLSFAKG DLIILDHDTG EQVMNSGWAN GINERTKQRG DFPTDCVYVM PTVTLPPREI
     VALVTMTPDQ RQDVVRLLQL RTAEPEVRAK PYTLEEFSYD YFRPPPKHTL SRVMVSKARG
     KDRLWSHTRE PLKQALLKKI LGSEELSQEA CMAFVAVLKY MGDYPSKRMR SVNELTDQIF
     EWALKAEPLK DEAYVQILKQ LTDNHIRYSE ERGWELLWLC TGLFPPSNIL LPHVQRFLQS
     RKHCPLAIDC LQRLQKALRN GSRKYPPHLV EVEAIQHKTT QIFHKVYFPD DTDEAFEVES
     STKAKDFCQN IASRLLLKSS EGFSLFVKIA DKVISVPEND FFFDFVRHLT DWIKKARPIK
     DGIVPSLTYQ VFFMKKLWTT TVPGKDPMAD SIFHYYQELP KYLRGYHKCT REEVLQLGAL
     IYRVKFEEDK SYFPSIPKLL RELVPQDLIR QVSPDDWKRS IVAYFNKHAG KSKEEAKLAF
     LKLIFKWPTF GSAFFEVKQT TEPNFPEILL IAINKYGVSL IDPRTKDILT THPFTKISNW
     SSGNTYFHIT IGNLVRGSKL LCETSLGYKM DDLLTSYISQ MLTAMSKQRN SRSGR
//

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