(data stored in ACNUC9543 zone)

HOGENOM: MOUSE7_PE2352

ID   MOUSE7_PE2352                        STANDARD;      PRT;   640 AA.
AC   MOUSE7_PE2352; O08688; Q91YU0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Calpain-5; EC=3.4.22 -;AltName: Full=New calpain 3;
DE   Short=nCL-3; (MOUSE7.PE2352).
GN   Name=Capn5; Synonyms=Ncl3;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE7.PE2352.
CC       Mus musculus chromosome 7 NCBIM37  sequence 1..152524553 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CAN5_MOUSE
CC   -!- CATALYTIC ACTIVITY: Broad endopeptidase specificity.
CC   -!- SIMILARITY: Belongs to the peptidase C2 family.
CC   -!- SIMILARITY: Contains 1 C2 domain.
CC   -!- SIMILARITY: Contains 1 calpain catalytic domain.
CC   -!- GENE_FAMILY: HOG000232036 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000035547;ENSMUST00000107112;ENSMUSP00000102729.
DR   EMBL; AC119880; - ;
DR   EMBL; AK139476; - ;
DR   EMBL; AK155179; - ;
DR   EMBL; AK164293; - ;
DR   EMBL; AK170034; - ;
DR   EMBL; BC014767; - ;
DR   EMBL; CH466531; - ;
DR   EMBL; U85020; - ;
DR   EMBL; Y10656; - ;
DR   UniProtKB/Swiss-Prot; O08688; Q91YU0; -.
DR   EMBL; Y10656; CAA71666.1; -; mRNA.
DR   EMBL; U85020; AAD00559.1; -; mRNA.
DR   EMBL; BC014767; AAH14767.1; -; mRNA.
DR   IPI; IPI00114962; -.
DR   RefSeq; NP_031628.1; NM_007602.3.
DR   UniGene; Mm.326847; -.
DR   ProteinModelPortal; O08688; -.
DR   SMR; O08688; 3-501, 516-631.
DR   STRING; O08688; -.
DR   MEROPS; C02.011; -.
DR   PhosphoSite; O08688; -.
DR   PRIDE; O08688; -.
DR   Ensembl; ENSMUST00000040971; ENSMUSP00000048183; ENSMUSG00000035547.
DR   Ensembl; ENSMUST00000107112; ENSMUSP00000102729; ENSMUSG00000035547.
DR   GeneID; 12337; -.
DR   KEGG; mmu:12337; -.
DR   CTD; 726; -.
DR   MGI; MGI:1100859; Capn5.
DR   eggNOG; roNOG11514; -.
DR   InParanoid; O08688; -.
DR   OMA; EQEWDPE; -.
DR   OrthoDB; EOG4DV5KQ; -.
DR   PhylomeDB; O08688; -.
DR   NextBio; 280956; -.
DR   ArrayExpress; O08688; -.
DR   Bgee; O08688; -.
DR   CleanEx; MM_CAPN5; -.
DR   Genevestigator; O08688; -.
DR   GermOnline; ENSMUSG00000035547; Mus musculus.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR000008; C2_Ca-dep.
DR   InterPro; IPR008973; C2_Ca/lipid-bd_dom_CaLB.
DR   InterPro; IPR022684; Calpain_cysteine_protease.
DR   InterPro; IPR022682; Calpain_domain_III.
DR   InterPro; IPR022683; Calpain_III.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF01067; Calpain_III; 1.
DR   Pfam; PF00648; Peptidase_C2; 1.
DR   PRINTS; PR00704; CALPAIN.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00720; calpain_III; 1.
DR   SMART; SM00230; CysPc; 1.
DR   SUPFAM; SSF49562; C2_CaLB; 1.
DR   SUPFAM; SSF49758; Peptidase_C2; 1.
DR   PROSITE; PS50004; C2; FALSE_NEG.
DR   PROSITE; PS50203; CALPAIN_CAT; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; FALSE_NEG.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; FALSE_NEG.
DR   HOGENOMDNA; MOUSE7.PE2352; -.
KW   ENSMUSG000000355475old_1320000031; ENSMUSP000001027291old_1320000031;
KW   D3YU84_MOUSE; Q3TDS7_MOUSE; Q3TPL4_MOUSE; Q3U2P3_MOUSE; Q3UTF3_MOUSE;
KW   AK139476; AK155179; AK164293; AK170034; BC014767; CH466531; U85020;
KW   Y10656;
KW   Complete proteome; Hydrolase; Polymorphism; Protease;
KW   Reference proteome; Thiol protease.
SQ   SEQUENCE   640 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MFSCAKAYED QNYSALKRAC LRKKVLFEDP LFPATDDSLY YKGTPGPTVR WKRPKDICDD
     PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV IPDWKEQEWN PEKPDSYAGI
     FHFNFWRFGE WVDVIVDDRL PTVNNQLIYC HSNSKNEFWC ALVEKAYAKL AGCYQALDGG
     NTADALVDFT GGVSEPIDLT EGDLATDEAK RNQLFERVLK VHSRGGLISA SIKAVTAADM
     EARLACGLVK GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERE WTGPWSDTSE
     EWQKVSKSER EKMGVTVQDD GEFWMTFEDM CRYFTDIIKC RLINTSYLSI HKTWEEARLH
     GAWTRHEDPQ QNRSGGCINH KDTFFQNPQY VFEVKKPEDE VLISIQQRPK RSTRREGKGE
     NLAIGFDIYK VEENRQYRMH SLQHKAASSI YINSRSVFLR TELPEGRYVI IPTTFEPGHT
     GEFLLRVFTD VPSNCRELRL DEPPRTCWSS LCGYPQQVAQ VHVLGAAGLK DSPTGANSYV
     IIKCEGEKVR SAVQRGTSTP EYNVKGIFYR KKLAQPITVQ VWNHRVLKDE FLGQVHLKTA
     PDDLQDLHTL HLQDRSSRQP SDLPGIVAVR VLCSASLTAV
//

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