(data stored in ACNUC30567 zone)

HOGENOM: MOUSE7_PE2357

ID   MOUSE7_PE2357                        STANDARD;      PRT;   267 AA.
AC   MOUSE7_PE2357; Q9D099; Q542R2; Q9D0X4; Q9D3J4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Alkaline ceramidase 3; Short=AlkCDase 3; Short=Alkaline
DE   CDase 3; EC=3.5.1 -;AltName: Full=Alkaline phytoceramidase; Short=aPHC;
DE   (MOUSE7.PE2357).
GN   Name=Acer3; Synonyms=Aphc, Phca;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE7.PE2357.
CC       Mus musculus chromosome 7 NCBIM37  sequence 1..152524553 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ACER3_MOUSE
CC   -!- FUNCTION: Hydrolyzes only phytoceramide into phytosphingosine and
CC       free fatty acid. Does not have reverse activity (By similarity).
CC   -!- ENZYME REGULATION: Activated by Ca(2+) and inhibited by Zn(2+) (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein (By similarity). Golgi apparatus membrane; Multi-
CC       pass membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the alkaline ceramidase family.
CC   -!- GENE_FAMILY: HOG000192011 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000030760;ENSMUST00000033020;ENSMUSP00000033020.
DR   EMBL; AC111084; - ;
DR   EMBL; AC119880; - ;
DR   EMBL; AK004287; - ;
DR   EMBL; AK011668; - ;
DR   EMBL; AK017361; - ;
DR   EMBL; AK080977; - ;
DR   EMBL; AK150629; - ;
DR   EMBL; AK162403; - ;
DR   EMBL; CH466531; - ;
DR   UniProtKB/Swiss-Prot; Q9D099; Q542R2; Q9D0X4; Q9D3J4; -.
DR   EMBL; AK004287; BAB23250.1; -; mRNA.
DR   EMBL; AK011668; BAB27768.1; -; mRNA.
DR   EMBL; AK017361; BAB30708.1; -; mRNA.
DR   EMBL; AK080977; BAC38101.1; -; mRNA.
DR   EMBL; AK150629; BAE29719.1; -; mRNA.
DR   EMBL; AK162403; BAE36897.1; -; mRNA.
DR   IPI; IPI00315345; -.
DR   RefSeq; NP_079684.2; NM_025408.2.
DR   UniGene; Mm.334041; -.
DR   STRING; Q9D099; -.
DR   PRIDE; Q9D099; -.
DR   Ensembl; ENSMUST00000033020; ENSMUSP00000033020; ENSMUSG00000030760.
DR   GeneID; 66190; -.
DR   KEGG; mmu:66190; -.
DR   UCSC; uc009ikg.1; mouse.
DR   CTD; 55331; -.
DR   MGI; MGI:1913440; Acer3.
DR   eggNOG; roNOG05405; -.
DR   GeneTree; ENSGT00510000048423; -.
DR   InParanoid; Q9D099; -.
DR   OMA; EPIFHQV; -.
DR   OrthoDB; EOG4S1T7P; -.
DR   PhylomeDB; Q9D099; -.
DR   NextBio; 320899; -.
DR   ArrayExpress; Q9D099; -.
DR   Bgee; Q9D099; -.
DR   CleanEx; MM_PHCA; -.
DR   Genevestigator; Q9D099; -.
DR   GermOnline; ENSMUSG00000030760; Mus musculus.
DR   GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InteDR   GO; GO:0006672; P:ceramide metabolic process; IEA:InterPro.
DR   GO; GO:0006672; P:ceramide metabolic process; IEA:InterPro.
DR   InterPro; IPR008901; Ceramidase.
DR   Pfam; PF05875; Ceramidase; 1.
DR   HOGENOMDNA; MOUSE7.PE2357; -.
KW   ENSMUSG000000307605old_1320000031; ENSMUSP000000330201old_1320000031;
KW   D3YTU8_MOUSE; AC111084; AC119880; AK004287; AK011668; AK017361; AK080977;
KW   AK162403; CH466531;
KW   Complete proteome; Endoplasmic reticulum; Golgi apparatus; Hydrolase;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   267 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAPAVDRKGY WGPTTSTLDW CEENYVVTLF VAEFWNTVSN LIMIIPPIFG AIQGIRDRLE
     KRYIAAYLAL TVVGMGSWCF HMTLKYEMQL LDELPMIYSC CIFVYCMFEC FKTKSSINYH
     LLFTLFLYSL TVTTIYLKVK EPIFHQVMYG MLVFTLVLRS IYIVTWVYPW LRGLGYTSLT
     VFLLGFLLWN IDNIFCDSLR NFRKRVPPVL GVTTQFHAWW HILTGLGSYL HILFSLYTRT
     LYLRYRPKVK FLFGIWPAVM FEPQRKH
//

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