(data stored in ACNUC30567 zone)

HOGENOM: MOUSE7_PE3020

ID   MOUSE7_PE3020                        STANDARD;      PRT;   820 AA.
AC   MOUSE7_PE3020; O08739; O88692; Q8CFR4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=AMP deaminase 3; EC=3.5.4 6;AltName: Full=AMP deaminase
DE   H-type;AltName: Full=AMP deaminase isoform E;AltName: Full=Heart-type
DE   AMPD; (MOUSE7.PE3020).
GN   Name=Ampd3;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE7.PE3020.
CC       Mus musculus chromosome 7 NCBIM37  sequence 1..152524553 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:AMPD3_MOUSE
CC   -!- FUNCTION: AMP deaminase plays a critical role in energy
CC       metabolism.
CC   -!- CATALYTIC ACTIVITY: AMP + H(2)O = IMP + NH(3).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway;
CC       IMP from AMP: step 1/1.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- TISSUE SPECIFICITY: Found in heart, lung brain, spleen, kidney and
CC       to a lesser extent in liver.
CC   -!- SIMILARITY: Belongs to the adenosine and AMP deaminases family.
CC   -!- GENE_FAMILY: HOG000092200 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000005686;ENSMUST00000155254;ENSMUSP00000123052.
DR   EMBL; AC122844; - ;
DR   EMBL; AK133465; - ;
DR   EMBL; BC007183; - ;
DR   EMBL; BC040366; - ;
DR   EMBL; BC056380; - ;
DR   EMBL; CH466531; - ;
DR   EMBL; D85596; - ;
DR   EMBL; D88994; - ;
DR   UniProtKB/Swiss-Prot; O08739; O88692; Q8CFR4; -.
DR   EMBL; D85596; BAA19933.1; -; mRNA.
DR   EMBL; D88994; BAA32548.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AK133465; BAE21671.1; -; mRNA.
DR   EMBL; CH466531; EDL16988.1; -; Genomic_DNA.
DR   EMBL; CH466531; EDL16989.1; -; Genomic_DNA.
DR   EMBL; CH466531; EDL16990.1; -; Genomic_DNA.
DR   EMBL; BC040366; AAH40366.1; -; mRNA.
DR   EMBL; BC056380; AAH56380.1; -; mRNA.
DR   IPI; IPI00275398; -.
DR   RefSeq; NP_033797.2; NM_009667.2.
DR   UniGene; Mm.3238; -.
DR   ProteinModelPortal; O08739; -.
DR   STRING; O08739; -.
DR   PhosphoSite; O08739; -.
DR   PRIDE; O08739; -.
DR   Ensembl; ENSMUST00000005829; ENSMUSP00000005829; ENSMUSG00000005686.
DR   Ensembl; ENSMUST00000170374; ENSMUSP00000130495; ENSMUSG00000005686.
DR   GeneID; 11717; -.
DR   CTD; 272; -.
DR   MGI; MGI:1096344; Ampd3.
DR   eggNOG; maNOG07179; -.
DR   InParanoid; O08739; -.
DR   OrthoDB; EOG4J9MZC; -.
DR   PhylomeDB; O08739; -.
DR   NextBio; 279393; -.
DR   ArrayExpress; O08739; -.
DR   Bgee; O08739; -.
DR   CleanEx; MM_AMPD3; -.
DR   Genevestigator; O08739; -.
DR   GermOnline; ENSMUSG00000005686; Mus musculus.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006144; P:purine base metabolic process; IEA:InterPro.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A/AMP_deaminase.
DR   InterPro; IPR006329; AMP_deaminase.
DR   InterPro; IPR016297; AMP_deaminase_met.
DR   Pfam; PF00962; A_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   TIGRFAMs; TIGR01429; AMP_deaminase; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
DR   HOGENOMDNA; MOUSE7.PE3020; -.
KW   ENSMUSG000000056865old_1320000031; ENSMUSP000001230521old_1320000031;
KW   D3YVP7_MOUSE; D3Z4N3_MOUSE; Q8CFR4_MOUSE; Q922J7_MOUSE; AC122844;
KW   BC007183; BC040366; BC056380; CH466531; D85596; D88994;
KW   Complete proteome; Hydrolase; Metal-binding; Nucleotide metabolism;
KW   Phosphoprotein; Reference proteome; Zinc.
SQ   SEQUENCE   820 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     VCVCVCVCVC VCVCVCVYTR APVCVGRGGK VIQGTGPTPG ENQRLLVGLA TKTEMPRQFP
     KLNMSDLDEH VRLLAEKVFA KVLREEDSKD VMSLFTVPED CPIGQKEAKE RELQKELAEQ
     KSVETAKRKK SFKMIRSQSL SLQMPTQQDW KGPPTASPAM SPATPLVPGA TSKPGPAPYA
     MPEYQRVTIS GDYCAGITVE DYEQAAKSLA KALMIREKYA RLAYHRFPRT TAQYLAHQGE
     SVPLEEGLPD FHPPPLPQED PYCLDDAPPN LGYLVRMHGG VLFVYDNQTM LERQEPHSLP
     YPDLETYIVD MSHILALITD GPTKTYCHRR LNFLESKFSL HEMLNEMSEF KELKSNPHRD
     FYNVRKVDTH IHAAACMNQK HLLRFIKHTY QTEPDRTVAE KLGRKITLRQ VFDSLHMDPY
     DLTVDSLDVH AGRQTFHRFD KFNSKYNPVG ASELRDLYLK TENYLGGEYF ARMVKEVARE
     LEDSKYQYSE PRLSIYGRSP KEWSSLARWF IQHKVYSPNM RWIIQVPRIY DIFRSKKLLP
     NFGKMLENIF LPLFKATINP QDHRELHLFL KYVTGFDSVD DESKHSDHMF SDKSPSPDLW
     TSEQNPPYSY YLYYMYANIM VLNNLRRERG LSTFLFRPHC GEAGSITHLV SAFLTADNIS
     HGLLLKKSPV LQYLYYLAQI PIAMSPLSNN SLFLEYSKNP LREFLHKGLH VSLSTDDPMQ
     FHYTKEALME EYAIAAQVWK LSTCDLCEIA RNSVLQSGLS HQEKQKFLGQ NYYKEGPEGN
     DIRKTNVAQI RMAFRYETLC NELSFLSDAM KSEEITALTK
//

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