(data stored in ACNUC30567 zone)

HOGENOM: MOUSE7_PE3021

ID   MOUSE7_PE3021                        STANDARD;      PRT;   766 AA.
AC   MOUSE7_PE3021; O08739; O88692; Q8CFR4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=AMP deaminase 3; EC=3.5.4 6;AltName: Full=AMP deaminase
DE   H-type;AltName: Full=AMP deaminase isoform E;AltName: Full=Heart-type
DE   AMPD; (MOUSE7.PE3021).
GN   Name=Ampd3;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE7.PE3021.
CC       Mus musculus chromosome 7 NCBIM37  sequence 1..152524553 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:AMPD3_MOUSE
CC   -!- FUNCTION: AMP deaminase plays a critical role in energy
CC       metabolism.
CC   -!- CATALYTIC ACTIVITY: AMP + H(2)O = IMP + NH(3).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway;
CC       IMP from AMP: step 1/1.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- TISSUE SPECIFICITY: Found in heart, lung brain, spleen, kidney and
CC       to a lesser extent in liver.
CC   -!- SIMILARITY: Belongs to the adenosine and AMP deaminases family.
CC   -!- GENE_FAMILY: HOG000092200 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000005686;ENSMUST00000005829;ENSMUSP00000005829.
DR   EMBL; AC122844; - ;
DR   EMBL; AK133465; - ;
DR   EMBL; BC007183; - ;
DR   EMBL; BC040366; - ;
DR   EMBL; BC056380; - ;
DR   EMBL; CH466531; - ;
DR   EMBL; D85596; - ;
DR   EMBL; D88994; - ;
DR   UniProtKB/Swiss-Prot; O08739; O88692; Q8CFR4; -.
DR   EMBL; D85596; BAA19933.1; -; mRNA.
DR   EMBL; D88994; BAA32548.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AK133465; BAE21671.1; -; mRNA.
DR   EMBL; CH466531; EDL16988.1; -; Genomic_DNA.
DR   EMBL; CH466531; EDL16989.1; -; Genomic_DNA.
DR   EMBL; CH466531; EDL16990.1; -; Genomic_DNA.
DR   EMBL; BC040366; AAH40366.1; -; mRNA.
DR   EMBL; BC056380; AAH56380.1; -; mRNA.
DR   IPI; IPI00275398; -.
DR   RefSeq; NP_033797.2; NM_009667.2.
DR   UniGene; Mm.3238; -.
DR   ProteinModelPortal; O08739; -.
DR   STRING; O08739; -.
DR   PhosphoSite; O08739; -.
DR   PRIDE; O08739; -.
DR   Ensembl; ENSMUST00000005829; ENSMUSP00000005829; ENSMUSG00000005686.
DR   Ensembl; ENSMUST00000170374; ENSMUSP00000130495; ENSMUSG00000005686.
DR   GeneID; 11717; -.
DR   CTD; 272; -.
DR   MGI; MGI:1096344; Ampd3.
DR   eggNOG; maNOG07179; -.
DR   InParanoid; O08739; -.
DR   OrthoDB; EOG4J9MZC; -.
DR   PhylomeDB; O08739; -.
DR   NextBio; 279393; -.
DR   ArrayExpress; O08739; -.
DR   Bgee; O08739; -.
DR   CleanEx; MM_AMPD3; -.
DR   Genevestigator; O08739; -.
DR   GermOnline; ENSMUSG00000005686; Mus musculus.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006144; P:purine base metabolic process; IEA:InterPro.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A/AMP_deaminase.
DR   InterPro; IPR006329; AMP_deaminase.
DR   InterPro; IPR016297; AMP_deaminase_met.
DR   Pfam; PF00962; A_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   TIGRFAMs; TIGR01429; AMP_deaminase; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
DR   HOGENOMDNA; MOUSE7.PE3021; -.
KW   ENSMUSG000000056865old_1320000031; ENSMUSP000000058291old_1320000031;
KW   D3YU73_MOUSE; D3YVP7_MOUSE; D3Z4N3_MOUSE; Q8CFR4_MOUSE; Q922J7_MOUSE;
KW   AK133465; BC007183; BC040366; BC056380; CH466531; D85596; D88994;
KW   Complete proteome; Hydrolase; Metal-binding; Nucleotide metabolism;
KW   Phosphoprotein; Reference proteome; Zinc.
SQ   SEQUENCE   766 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPRQFPKLNM SDLDEHVRLL AEKVFAKVLR EEDSKDVMSL FTVPEDCPIG QKEAKERELQ
     KELAEQKSVE TAKRKKSFKM IRSQSLSLQM PTQQDWKGPP TASPAMSPAT PLVPGATSKP
     GPAPYAMPEY QRVTISGDYC AGITVEDYEQ AAKSLAKALM IREKYARLAY HRFPRTTAQY
     LAHQGESVPL EEGLPDFHPP PLPQEDPYCL DDAPPNLGYL VRMHGGVLFV YDNQTMLERQ
     EPHSLPYPDL ETYIVDMSHI LALITDGPTK TYCHRRLNFL ESKFSLHEML NEMSEFKELK
     SNPHRDFYNV RKVDTHIHAA ACMNQKHLLR FIKHTYQTEP DRTVAEKLGR KITLRQVFDS
     LHMDPYDLTV DSLDVHAGRQ TFHRFDKFNS KYNPVGASEL RDLYLKTENY LGGEYFARMV
     KEVARELEDS KYQYSEPRLS IYGRSPKEWS SLARWFIQHK VYSPNMRWII QVPRIYDIFR
     SKKLLPNFGK MLENIFLPLF KATINPQDHR ELHLFLKYVT GFDSVDDESK HSDHMFSDKS
     PSPDLWTSEQ NPPYSYYLYY MYANIMVLNN LRRERGLSTF LFRPHCGEAG SITHLVSAFL
     TADNISHGLL LKKSPVLQYL YYLAQIPIAM SPLSNNSLFL EYSKNPLREF LHKGLHVSLS
     TDDPMQFHYT KEALMEEYAI AAQVWKLSTC DLCEIARNSV LQSGLSHQEK QKFLGQNYYK
     EGPEGNDIRK TNVAQIRMAF RYETLCNELS FLSDAMKSEE ITALTK
//

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