(data stored in ACNUC14577 zone)

HOGENOM: MOUSE7_PE3250

ID   MOUSE7_PE3250                        STANDARD;      PRT;   603 AA.
AC   MOUSE7_PE3250; Q6P5E6; Q3U374; Q6PFX3; Q6ZPY8; Q8BM76; Q9DC15;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=ADP-ribosylation factor-binding protein GGA2;AltName:
DE   Full=Gamma-adaptin-related protein 2;AltName: Full=Golgi-localized, gamma
DE   ear-containing, ARF-binding protein 2; (MOUSE7.PE3250).
GN   Name=Gga2; Synonyms=Kiaa1080;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE7.PE3250.
CC       Mus musculus chromosome 7 NCBIM37  sequence 1..152524553 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:GGA2_MOUSE
CC   -!- FUNCTION: Plays a role in protein sorting and trafficking between
CC       the trans-Golgi network (TGN) and endosomes. Mediates the ARF-
CC       dependent recruitment of clathrin to the TGN and binds
CC       ubiquitinated proteins and membrane cargo molecules with a
CC       cytosolic acidic cluster-dileucine (AC-LL) motif (By similarity).
CC   -!- SUBUNIT: Monomer. Interacts with NECAP1, TSG101, UBC and
CC       AFTPH/aftiphilin. Interacts with GGA1 and GGA3. Binds to clathrin
CC       and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the
CC       type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR,
CC       IGF2R/CI-MPR and BACE1. Binds CCDC91, P200, SYNRG, EPN4 and NECAP2
CC       (By similarity). Interacts with CNST.
CC   -!- INTERACTION:
CC       Q8CBC4-3:Cnst; NbExp=2; IntAct=EBI-2616239, EBI-2615407;
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC       membrane; Peripheral membrane protein (By similarity). Endosome
CC       membrane; Peripheral membrane protein (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6P5E6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6P5E6-2; Sequence=VSP_013255;
CC   -!- DOMAIN: The VHS domain functions as a recognition module for
CC       sorting signals composed of an acidic cluster followed by two
CC       leucines (AC-LL motif) (By similarity).
CC   -!- DOMAIN: The GAT domain is responsible for interaction with ARF-
CC       GTP, UBC and RABEP1. Required for recruitment to the TGN it
CC       prevents ARF-GTP hydrolysis (By similarity).
CC   -!- DOMAIN: The unstructured hinge region contains clathrin-binding
CC       but no autoinhibitory (AC-LL) motifs (By similarity).
CC   -!- DOMAIN: The GAE domain binds accessory proteins regulating GGAs
CC       function (By similarity).
CC   -!- PTM: Ubiquitinated (By similarity).
CC   -!- SIMILARITY: Belongs to the GGA protein family.
CC   -!- SIMILARITY: Contains 1 GAE domain.
CC   -!- SIMILARITY: Contains 1 GAT domain.
CC   -!- SIMILARITY: Contains 1 VHS domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC28769.1; Type=Erroneous initiation;
CC       Sequence=BAC98090.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000231169 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000030872;ENSMUST00000033160;ENSMUSP00000033160.
DR   EMBL; AK004632; - ;
DR   EMBL; AK034612; - ;
DR   EMBL; AK129280; - ;
DR   EMBL; AK143691; - ;
DR   EMBL; AK149798; - ;
DR   EMBL; AK154904; - ;
DR   EMBL; AK159953; - ;
DR   EMBL; BC057377; - ;
DR   EMBL; BC062933; - ;
DR   UniProtKB/Swiss-Prot; Q6P5E6; Q3U374; Q6PFX3; Q6ZPY8; Q8BM76; Q9DC15; -.
DR   EMBL; AK004632; BAB23426.1; -; mRNA.
DR   EMBL; AK034612; BAC28769.1; ALT_INIT; mRNA.
DR   EMBL; AK129280; BAC98090.1; ALT_INIT; mRNA.
DR   EMBL; AK143691; BAE25501.1; -; mRNA.
DR   EMBL; AK154904; BAE32915.1; -; mRNA.
DR   EMBL; BC057377; AAH57377.1; -; mRNA.
DR   EMBL; BC062933; AAH62933.1; -; mRNA.
DR   IPI; IPI00467384; -.
DR   IPI; IPI00554846; -.
DR   RefSeq; NP_083034.1; NM_028758.2.
DR   UniGene; Mm.29619; -.
DR   ProteinModelPortal; Q6P5E6; -.
DR   SMR; Q6P5E6; 28-170, 190-318, 458-602.
DR   IntAct; Q6P5E6; 2.
DR   MINT; MINT-1342264; -.
DR   STRING; Q6P5E6; -.
DR   PhosphoSite; Q6P5E6; -.
DR   PRIDE; Q6P5E6; -.
DR   Ensembl; ENSMUST00000033160; ENSMUSP00000033160; ENSMUSG00000030872.
DR   Ensembl; ENSMUST00000124566; ENSMUSP00000115581; ENSMUSG00000030872.
DR   GeneID; 74105; -.
DR   KEGG; mmu:74105; -.
DR   UCSC; uc009joa.1; mouse.
DR   UCSC; uc009joc.1; mouse.
DR   CTD; 23062; -.
DR   MGI; MGI:1921355; Gga2.
DR   GeneTree; ENSGT00600000084107; -.
DR   InParanoid; Q6P5E6; -.
DR   OMA; WATEKVK; -.
DR   OrthoDB; EOG4894M5; -.
DR   PhylomeDB; Q6P5E6; -.
DR   NextBio; 339786; -.
DR   ArrayExpress; Q6P5E6; -.
DR   Bgee; Q6P5E6; -.
DR   Genevestigator; Q6P5E6; -.
DR   GermOnline; ENSMUSG00000030872; Mus musculus.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR013041; Clathrin/coatomer_app_Ig-like.
DR   InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR   InterPro; IPR008153; Clathrin_g-adaptin_app.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR004152; GAT.
DR   InterPro; IPR002014; VHS.
DR   InterPro; IPR018205; VHS_subgr.
DR   Gene3D; G3DSA:2.60.40.1230; Clathrin_g-adaptin_app; 1.
DR   Gene3D; G3DSA:1.25.40.90; ENTH_VHS; 1.
DR   Pfam; PF02883; Alpha_adaptinC2; 1.
DR   Pfam; PF03127; GAT; 1.
DR   Pfam; PF00790; VHS; 1.
DR   SMART; SM00809; Alpha_adaptinC2; 1.
DR   SMART; SM00288; VHS; 1.
DR   SUPFAM; SSF49348; Clath_adapt; 1.
DR   SUPFAM; SSF48464; ENTH_VHS; 1.
DR   PROSITE; PS50180; GAE; 1.
DR   PROSITE; PS50909; GAT; 1.
DR   PROSITE; PS50179; VHS; 1.
DR   HOGENOMDNA; MOUSE7.PE3250; -.
KW   ENSMUSG000000308725old_1320000031; ENSMUSP000000331601old_1320000031;
KW   Q3TVV9_MOUSE; Q3UE19_MOUSE; AK004632; AK034612; AK129280; AK143691;
KW   AK154904; AK159953; BC057377; BC062933;
KW   Alternative splicing; Complete proteome; Endosome; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Transport;
KW   Ubl conjugation.
SQ   SEQUENCE   603 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAATAVAAGT GSPAGTESAE GGPGAAAALE LWLNKATDPS MAEQDWSAIQ KFCEQVNTDP
     SGPTHAPWLL AHKIQSPQEK EALYALTVLE ICMNHCGEKF HSEVAKFRFL NELIKVLSPK
     YLGAWATEKV KGRVIEILFS WTVWFPEDIK IRDAYQMLKK QGIIKQDPKL PMDKILPPPS
     PWPKSIFDAD EEKSKLLTRL LKSNHPEDLQ AANRLIKNLV KEEQEKSEKV SRRVSAVEEV
     RSHVRVLREM LSMYRRPGHA LPDQQALQVV YERCEKLRPT LFRLASDTTD DDDALAEILQ
     ANDLLTQGVR LYKQVVEGRV SAGNAVPAAV GAIPAPRAFP NPEPCGLNCP LIDLETPSLL
     HQDLAALGIN DVPTRNQVVI PSCCNDKKQP GAITLMGGGI QSLSADRNLL DLFSPQPSPG
     LNYVPQKSIP KEVPPGTKAS PGWSWEAGPL ASSTASQNTP LAHVFVPLES VKPSSLPPIV
     VYDRNGFRIL LHFSQTGAPG HPDVKVLLLT MMSTATQPVW DVMFQVAVPK SMRVKLQPAS
     SSKLPAFSPL MPPAVISQTL LLDNPHKEPI RLRYKLTFNQ GGQPFSEVGE VKDFPDLAVL
     STA
//

If you have problems or comments...

PBIL Back to PBIL home page