(data stored in ACNUC7421 zone)

HOGENOM: MOUSE7_PE3864

ID   MOUSE7_PE3864                        STANDARD;      PRT;   290 AA.
AC   MOUSE7_PE3864; Q8BH95; Q3TJK2; Q6GQS2; Q6PEN1; Q99LX7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Enoyl-CoA hydratase, mitochondrial; EC=4.2.1 17;AltName:
DE   Full=Enoyl-CoA hydratase 1;AltName: Full=Short-chain enoyl-CoA hydratase;
DE   Short=SCEH;Flags: Precursor; (MOUSE7.PE3864).
GN   Name=Echs1;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE7.PE3864.
CC       Mus musculus chromosome 7 NCBIM37  sequence 1..152524553 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ECHM_MOUSE
CC   -!- FUNCTION: Straight-chain enoyl-CoA thioesters from C4 up to at
CC       least C16 are processed, although with decreasing catalytic rate
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-
CC       CoA + H(2)O.
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC   -!- SUBUNIT: Homohexamer; dimer of trimers (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
CC   -!- PTM: Acetylation of Lys-101 is observed in liver mitochondria from
CC       fasted mice but not from fed mice.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC   -!- GENE_FAMILY: HOG000027939 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000025465;ENSMUST00000026538;ENSMUSP00000026538.
DR   EMBL; AK040391; - ;
DR   EMBL; AK044954; - ;
DR   EMBL; AK086762; - ;
DR   EMBL; AK088018; - ;
DR   EMBL; AK167404; - ;
DR   EMBL; BC002178; - ;
DR   EMBL; BC057971; - ;
DR   EMBL; BC072658; - ;
DR   EMBL; CH466531; - ;
DR   UniProtKB/Swiss-Prot; Q8BH95; Q3TJK2; Q6GQS2; Q6PEN1; Q99LX7; -.
DR   EMBL; AK040391; BAC30583.1; -; mRNA.
DR   EMBL; AK044954; BAC32157.1; -; mRNA.
DR   EMBL; AK088018; BAC40099.1; -; mRNA.
DR   EMBL; AK167404; BAE39493.1; -; mRNA.
DR   EMBL; BC002178; AAH02178.1; -; mRNA.
DR   EMBL; BC057971; AAH57971.1; -; mRNA.
DR   EMBL; BC072658; AAH72658.1; -; mRNA.
DR   IPI; IPI00454049; -.
DR   RefSeq; NP_444349.1; NM_053119.2.
DR   UniGene; Mm.24452; -.
DR   ProteinModelPortal; Q8BH95; -.
DR   SMR; Q8BH95; 31-290.
DR   STRING; Q8BH95; -.
DR   PhosphoSite; Q8BH95; -.
DR   REPRODUCTION-2DPAGE; Q8BH95; -.
DR   PRIDE; Q8BH95; -.
DR   Ensembl; ENSMUST00000026538; ENSMUSP00000026538; ENSMUSG00000025465.
DR   GeneID; 93747; -.
DR   KEGG; mmu:93747; -.
DR   NMPDR; fig|10090.3.peg.17872; -.
DR   UCSC; uc009kgx.1; mouse.
DR   CTD; 1892; -.
DR   MGI; MGI:2136460; Echs1.
DR   eggNOG; roNOG08852; -.
DR   InParanoid; Q8BH95; -.
DR   OMA; TGNMINA; -.
DR   OrthoDB; EOG4P2Q32; -.
DR   PhylomeDB; Q8BH95; -.
DR   NextBio; 351613; -.
DR   ArrayExpress; Q8BH95; -.
DR   Bgee; Q8BH95; -.
DR   Genevestigator; Q8BH95; -.
DR   GermOnline; ENSMUSG00000025465; Mus musculus.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:EC.
DR   InterPro; IPR014748; Crontonase_C.
DR   InterPro; IPR001753; Crotonase_core.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   Gene3D; G3DSA:1.10.12.10; Crontonase_C; 1.
DR   Pfam; PF00378; ECH; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
DR   HOGENOMDNA; MOUSE7.PE3864; -.
KW   ENSMUSG000000254655old_1320000031; ENSMUSP000000265381old_1320000031;
KW   Q8BU95_MOUSE; AK040391; AK044954; AK086762; AK088018; AK167404; BC002178;
KW   BC072658; CH466531;
KW   Acetylation; Complete proteome; Direct protein sequencing;
KW   Fatty acid metabolism; Lipid metabolism; Lyase; Mitochondrion;
KW   Reference proteome; Transit peptide.
SQ   SEQUENCE   290 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAALRALLPR ACSSLLSSVR CPELRRFASG ANFQYIITEK KGKNSSVGLI QLNRPKALNA
     LCNGLIEELN QALETFEQDP AVGAIVLTGG DKAFAAGADI KEMQNRTFQD CYSSKFLSHW
     DHITRVKKPV IAAVNGYALG GGCELAMMCD IIYAGEKAQF GQPEILLGTI PGAGGTQRLT
     RAVGKSLAME MVLTGDRISA QDAKQAGLVS KIFPVEKLVE EAIQCAEKIA SNSKIVVAMA
     KESVNAAFEM TLTEGNKLEK RLFYSTFATD DRREGMTAFV EKRKANFKDH
//

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