(data stored in ACNUC31108 zone)

HOGENOM: MOUSE7_PE4119

ID   MOUSE7_PE4119                        STANDARD;      PRT;   236 AA.
AC   MOUSE7_PE4119; P35762;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=CD81 antigen;AltName: Full=26 kDa cell surface protein
DE   TAPA-1;AltName: Full=Target of the antiproliferative antibody 1;AltName:
DE   CD_antigen=CD81; (MOUSE7.PE4119).
GN   Name=Cd81; Synonyms=Tapa1;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE7.PE4119.
CC       Mus musculus chromosome 7 NCBIM37  sequence 1..152524553 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CD81_MOUSE
CC   -!- FUNCTION: May play an important role in the regulation of lymphoma
CC       cell growth. May be involved in the acrosome reaction.
CC   -!- SUBUNIT: Interacts directly with IGSF8.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in oocytes. Highly expressed in
CC       granulosa cells.
CC   -!- PTM: Not glycosylated (Probable).
CC   -!- DISRUPTION PHENOTYPE: Reduction in the fecundity of female mice
CC       and their eggs have impaired ability to fuse with sperm.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000037706;ENSMUST00000037941;ENSMUSP00000043768.
DR   EMBL; AJ251835; - ;
DR   EMBL; AK136370; - ;
DR   EMBL; AK166521; - ;
DR   EMBL; AK170741; - ;
DR   EMBL; BC011433; - ;
DR   EMBL; CH466531; - ;
DR   EMBL; S44957; - ;
DR   EMBL; S44966; - ;
DR   EMBL; S45001; - ;
DR   EMBL; S45008; - ;
DR   EMBL; S45010; - ;
DR   EMBL; S45012; - ;
DR   EMBL; X59047; - ;
DR   UniProtKB/Swiss-Prot; P35762; -.
DR   EMBL; S45012; AAB19417.1; -; Genomic_DNA.
DR   EMBL; S44957; AAB19417.1; JOINED; Genomic_DNA.
DR   EMBL; S44966; AAB19417.1; JOINED; Genomic_DNA.
DR   EMBL; S45001; AAB19417.1; JOINED; Genomic_DNA.
DR   EMBL; S45008; AAB19417.1; JOINED; Genomic_DNA.
DR   EMBL; S45010; AAB19417.1; JOINED; Genomic_DNA.
DR   EMBL; X59047; -; NOT_ANNOTATED_CDS; mRNA.
DR   IPI; IPI00310916; -.
DR   PIR; A46472; A46472.
DR   UniGene; Mm.806; -.
DR   ProteinModelPortal; P35762; -.
DR   SMR; P35762; 113-201.
DR   STRING; P35762; -.
DR   PhosphoSite; P35762; -.
DR   PRIDE; P35762; -.
DR   MGI; MGI:1096398; Cd81.
DR   eggNOG; roNOG11432; -.
DR   InParanoid; P35762; -.
DR   OrthoDB; EOG4X97J1; -.
DR   ArrayExpress; P35762; -.
DR   Bgee; P35762; -.
DR   CleanEx; MM_CD81; -.
DR   Genevestigator; P35762; -.
DR   GermOnline; ENSMUSG00000037706; Mus musculus.
DR   GO; GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
DR   GO; GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
DR   GO; GO:0006661; P:phosphatidylinositol biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0043128; P:positive regulation of 1-phosphatidylinositol 4-kinase activity; ISS:UniProtKB.
DR   GO; GO:0030890; P:positive regulation of B cell proliferation; TAS:UniProtKB.
DR   GO; GO:0030307; P:positive regulation of cell growth; TAS:UniProtKB.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   InterPro; IPR023396; CD81_extracellular.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Gene3D; G3DSA:1.10.1450.10; G3DSA:1.10.1450.10; 1.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; MOUSE7.PE4119; -.
KW   ENSMUSG000000377065old_1320000031; ENSMUSP000000437681old_1320000031;
KW   Q3UWG5_MOUSE; Q91V78_MOUSE; AJ251835; AK136370; AK166521; AK170741;
KW   CH466531; S44957; S44966; S45001; S45008; S45010; S45012; X59047;
KW   Complete proteome; Direct protein sequencing; Disulfide bond;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   236 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTSLLYLELG NKPAPNTFYV
     GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI LFACEVAAGI WGFVNKDQIA
     KDVKQFYDQA LQQAVMDDDA NNAKAVVKTF HETLNCCGSN ALTTLTTTIL RNSLCPSGGN
     ILTPLLQQDC HQKIDELFSG KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY
//

If you have problems or comments...

PBIL Back to PBIL home page