(data stored in ACNUC23329 zone)

HOGENOM: MOUSE8_PE1469

ID   MOUSE8_PE1469                        STANDARD;      PRT;   395 AA.
AC   MOUSE8_PE1469; O35188; O35933; Q91V44;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Fractalkine;AltName: Full=C-X3-C motif chemokine 1;AltName:
DE   Full=CX3C membrane-anchored chemokine;AltName: Full=Neurotactin;AltName:
DE   Full=Small-inducible cytokine D1;Contains: RecName: Full=Processed
DE   fractalkine;Flags: Precursor; (MOUSE8.PE1469).
GN   Name=Cx3cl1; Synonyms=Cx3c, Fkn, Scyd1;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE8.PE1469.
CC       Mus musculus chromosome 8 NCBIM37  sequence 1..131738871 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:X3CL1_MOUSE
CC   -!- FUNCTION: Chemotactic for neutrophils both in vitro and in vivo.
CC       Results of chemotaxis assays suggest differential activation in
CC       vivo. The membrane-bound form promotes adhesion of leukocytes to
CC       endothelial cells (By similarity). May play a role in regulating
CC       leukocyte adhesion and migration processes at the endothelium (By
CC       similarity). Binds to CX3CR1.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Processed fractalkine: Secreted.
CC   -!- TISSUE SPECIFICITY: Highest levels in brain. Lower levels in
CC       kidney, heart and lung. Also found in skeletal muscle and testis.
CC   -!- PTM: A soluble short 95 kDa form may be released by proteolytic
CC       cleavage from the long membrane-anchored form.
CC   -!- SIMILARITY: Belongs to the intercrine delta family.
CC   -!- GENE_FAMILY: HOG000036946 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000031778;ENSMUST00000034230;ENSMUSP00000034230.
DR   EMBL; AF010586; - ;
DR   EMBL; AF071549; - ;
DR   EMBL; AK040220; - ;
DR   EMBL; AK138214; - ;
DR   EMBL; AK138472; - ;
DR   EMBL; AK138574; - ;
DR   EMBL; AK154646; - ;
DR   EMBL; BC006650; - ;
DR   EMBL; BC054838; - ;
DR   EMBL; CH466525; - ;
DR   EMBL; U92565; - ;
DR   UniProtKB/Swiss-Prot; O35188; O35933; Q91V44; -.
DR   EMBL; AF010586; AAB66331.1; -; mRNA.
DR   EMBL; U92565; AAB71763.1; -; mRNA.
DR   EMBL; AF071549; AAD41620.1; -; mRNA.
DR   EMBL; AK138214; BAE23585.1; -; mRNA.
DR   EMBL; AK138472; BAE23673.1; -; mRNA.
DR   EMBL; AK138574; BAE23702.1; -; mRNA.
DR   EMBL; AK154646; BAE32737.1; -; mRNA.
DR   EMBL; CH466525; EDL11144.1; -; Genomic_DNA.
DR   EMBL; BC006650; AAH06650.1; -; mRNA.
DR   EMBL; BC054838; AAH54838.1; -; mRNA.
DR   IPI; IPI00127811; -.
DR   RefSeq; NP_033168.2; NM_009142.3.
DR   UniGene; Mm.103711; -.
DR   ProteinModelPortal; O35188; -.
DR   STRING; O35188; -.
DR   PhosphoSite; O35188; -.
DR   PRIDE; O35188; -.
DR   Ensembl; ENSMUST00000034230; ENSMUSP00000034230; ENSMUSG00000031778.
DR   GeneID; 20312; -.
DR   KEGG; mmu:20312; -.
DR   CTD; 6376; -.
DR   MGI; MGI:1097153; Cx3cl1.
DR   eggNOG; roNOG08426; -.
DR   GeneTree; ENSGT00510000049483; -.
DR   InParanoid; O35188; -.
DR   OrthoDB; EOG415GDN; -.
DR   ArrayExpress; O35188; -.
DR   Bgee; O35188; -.
DR   CleanEx; MM_CX3CL1; -.
DR   Genevestigator; O35188; -.
DR   GermOnline; ENSMUSG00000031778; Mus musculus.
DR   GO; GO:0009986; C:cell surface; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008009; F:chemokine activity; IDA:MGI.
DR   GO; GO:0060055; P:angiogenesis involved in wound healing; IMP:MGI.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IMP:MGI.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IDA:MGI.
DR   GO; GO:0048246; P:macrophage chemotaxis; IMP:MGI.
DR   GO; GO:0043066; P:negative regulation of apoptosis; IDA:MGI.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IDA:MGI.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IMP:MGI.
DR   GO; GO:0032914; P:positive regulation of transforming growth factor-beta1 production; IMP:MGI.
DR   InterPro; IPR008097; Chemokine_fractalkine_CX3CL1.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR01721; FRACTALKINE.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Chemokine_IL8; 1.
DR   HOGENOMDNA; MOUSE8.PE1469; -.
KW   ENSMUSG000000317785old_1320000031; ENSMUSP000000342301old_1320000031;
KW   Q8C9Y1_MOUSE; Q91V44_MOUSE; AF010586; AF071549; AK040220; AK138214;
KW   AK138574; AK154646; BC006650; BC054838; CH466525; U92565;
KW   Cell adhesion; Cell membrane; Complete proteome; Cytokine;
KW   Disulfide bond; Membrane; Reference proteome; Secreted; Signal;
KW   Transmembrane; Transmembrane helix.
SQ   SEQUENCE   395 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAPSPLAWLL RLAAFFHLCT LLPGQHLGMT KCEIMCDKMT SRIPVALLIR YQLNQESCGK
     RAIVLETTQH RRFCADPKEK WVQDAMKHLD HQAAALTKNG GKFEKRVDNV TPGITLATRG
     LSPSALTKPE SATLEDLALE LTTISQEARG TMGTSQEPPA AVTGSSLSTS EAQDAGLTAK
     PQSIGSFEAA DISTTVWPSP AVYQSGSSSW AEEKATESPS TTAPSPQVST TSPSTPEENV
     GSEGQPPWVQ GQDLSPEKSL GSEEINPVHT DNFQERGPGN TVHPSVAPIS SEETPSPELV
     ASGSQAPKIE EPIHATADPQ KLSVLITPVP DTQAATRRQA VGLLAFLGLL FCLGVAMFAY
     QSLQGCPRKM AGEMVEGLRY VPRSCGSNSY VLVPV
//

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