(data stored in ACNUC30567 zone)

HOGENOM: MOUSE8_PE385

ID   MOUSE8_PE385                         STANDARD;      PRT;   751 AA.
AC   MOUSE8_PE385;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Disintegrin and metalloproteinase domain-containing protein
DE   5;AltName: Full=Transmembrane metalloproteinase-like, disintegrin-like,
DE   and cysteine-rich protein II; Short=tMDC II;Flags: Precursor;
DE   (MOUSE8.PE385).
GN   Name=Adam5; Synonyms=Tmdc2;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE8.PE385.
CC       Mus musculus chromosome 8 NCBIM37  sequence 1..131738871 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ADAM5_MOUSE
CC   -!- FUNCTION: This is a non catalytic metalloprotease-like protein.
CC       May play a role in sperm-egg fusion (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q3TTE0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3TTE0-2; Sequence=VSP_035338;
CC         Note=No experimental confirmation available;
CC       Name=3;
CC         IsoId=Q3TTE0-3; Sequence=VSP_035334, VSP_035337;
CC         Note=No experimental confirmation available;
CC       Name=4;
CC         IsoId=Q3TTE0-4; Sequence=VSP_035335, VSP_035336;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Detected in brain, kidney, liver, lung, spleen
CC       and ovary. Highly expressed in testis.
CC   -!- PTM: Subject to proteolytic processing during epididymal transit
CC       of spermatozoa (By similarity).
CC   -!- SIMILARITY: Contains 1 disintegrin domain.
CC   -!- SIMILARITY: Contains 1 EGF-like domain.
CC   -!- SIMILARITY: Contains 1 peptidase M12B domain.
CC   -!- CAUTION: Not expected to have protease activity.
CC   -!- GENE_FAMILY: HOG000230883 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000031554;ENSMUST00000118419;ENSMUSP00000112422.
DR   EMBL; AK016574; - ;
DR   EMBL; AK029519; - ;
DR   EMBL; AK161262; - ;
DR   EMBL; AK161415; - ;
DR   EMBL; AK161417; - ;
DR   EMBL; BC094237; - ;
DR   EMBL; U06150; - ;
DR   EMBL; U22059; - ;
DR   UniProtKB/Swiss-Prot; Q3TTE0; Q3TTE2; Q52KQ5; Q60623; Q60816; Q8CDV5; Q9D4F0; -.
DR   EMBL; U22059; AAA74923.1; -; mRNA.
DR   EMBL; AK016574; BAB30315.1; -; mRNA.
DR   EMBL; AK029519; BAC26490.1; -; mRNA.
DR   EMBL; AK161262; BAE36276.1; -; mRNA.
DR   EMBL; AK161415; BAE36383.1; -; mRNA.
DR   EMBL; AK161417; BAE36385.1; -; mRNA.
DR   EMBL; BC094237; AAH94237.1; -; mRNA.
DR   IPI; IPI00461440; -.
DR   IPI; IPI00875026; -.
DR   IPI; IPI00903405; -.
DR   IPI; IPI00903415; -.
DR   PIR; I48948; I48948.
DR   RefSeq; NP_031427.2; NM_007401.2.
DR   UniGene; Mm.143889; -.
DR   ProteinModelPortal; Q3TTE0; -.
DR   SMR; Q3TTE0; 182-620, 628-657.
DR   STRING; Q3TTE0; -.
DR   PRIDE; Q3TTE0; -.
DR   Ensembl; ENSMUST00000050300; ENSMUSP00000052661; ENSMUSG00000031554.
DR   Ensembl; ENSMUST00000110653; ENSMUSP00000106283; ENSMUSG00000031554.
DR   Ensembl; ENSMUST00000118419; ENSMUSP00000112422; ENSMUSG00000031554.
DR   Ensembl; ENSMUST00000164090; ENSMUSP00000132925; ENSMUSG00000031554.
DR   GeneID; 11499; -.
DR   KEGG; mmu:11499; -.
DR   UCSC; uc009lff.1; mouse.
DR   UCSC; uc009lfg.1; mouse.
DR   UCSC; uc012gbm.1; mouse.
DR   UCSC; uc012gbn.1; mouse.
DR   CTD; 11499; -.
DR   MGI; MGI:104730; Adam5.
DR   OMA; DKNLFDY; -.
DR   NextBio; 278894; -.
DR   ArrayExpress; Q3TTE0; -.
DR   Bgee; Q3TTE0; -.
DR   Genevestigator; Q3TTE0; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR001762; Blood-coag_inhib_Disintegrin.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR013032; EGF-like_reg_CS.
DR   InterPro; IPR000742; EGF_3.
DR   InterPro; IPR024079; MetalloPept_cat_dom.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   Gene3D; G3DSA:4.10.70.10; Blood-coag_inhib_Disintegrin; 1.
DR   Gene3D; G3DSA:3.40.390.10; G3DSA:3.40.390.10; 1.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; Disintegrin; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS00022; EGF_1; FALSE_NEG.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   HOGENOMDNA; MOUSE8.PE385; -.
KW   ENSMUSG000000315545old_1320000031; ENSMUSP000001124221old_1320000031;
KW   Q78E93_MOUSE; AK016574; AK029519; AK161262; AK161415; AK161417; BC094237;
KW   U22059;
KW   Alternative splicing; Complete proteome; Disulfide bond;
KW   EGF-like domain; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   751 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MFLLLLLFLH LKGLQAGQNP QKTTLQTTVP EKISSPDVET DAEDHMAYLI TINETPHFIH
     LKKQSFITPT AVVYTYDRND VQHSQPLSAL ENCNYNGYVA GFPNSIVTLT VCTGLRGIIQ
     FENVSYAIEP VETLSGFVHV IYENTNKHAV IPDLGKNQSY SWFDESDYQF RSNMKKSGFT
     VLRQRFIMMD IIVDKKLFDY MGSDTEVVLQ KVIQIIGFVN TMLSKLKLTV LINSIEIWSK
     ENRIRLSKAV DDLLVQFSIW KHEYRSQHVA YLLAFEEHPA STGALYPGNL CKLEYNAAVA
     LYPKGLSLES FSVIVLQLLS IGMGLTYDTE NCHCTGEVCL MTPKAIYSGG VKDFSTCTLD
     DFKYLSTRQD LRCLQDLPLE RKPARRPRRI CGNGILEMNE QCDCGTLKNC THRKCCDPMS
     CRLKNKATCG SGECCSQDCT VKMNDVVCRK SVDECDFVEY CNGKDPYCVP NTYARNGQYC
     ESGEAFCFEG RCQTADKQCM SMLGKYVRGA SFACYEEFNS RGDRFGNCIH NFCAFRNSLC
     GKLICTWPFK KLVLKANLSV AYAQIRDDLC VAMYKGGRIP KTTKTTYSNP ADRDETFVND
     GTICGPDMFC LRASCTETRF HMDSSKCDST RDCNDHGVCN NLQHCHCDIG YNPPFCEEHK
     GQFGSVDDGH KYHVEDGKSY KQQSHSNLKK NQLQLILYIS LPLLVMISAV VIKQSKLSRV
     CDRERSESDS STTEDSGSNT NVTSSGGSTS H
//

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