(data stored in ACNUC30567 zone)

HOGENOM: MOUSE8_PE389

ID   MOUSE8_PE389                         STANDARD;      PRT;   750 AA.
AC   MOUSE8_PE389; Q8K410; Q6P901; Q8BJ80;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Disintegrin and metalloproteinase domain-containing protein
DE   32; Short=ADAM 32;Flags: Precursor; (MOUSE8.PE389).
GN   Name=Adam32;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE8.PE389.
CC       Mus musculus chromosome 8 NCBIM37  sequence 1..131738871 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ADA32_MOUSE
CC   -!- FUNCTION: May play a role in sperm development and fertilization
CC       This is a non-catalytic metalloprotease-like protein.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8K410-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8K410-2; Sequence=VSP_012052;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Highly expressed in the testis and weakly
CC       expressed in the epididymis, brain and heart.
CC   -!- DEVELOPMENTAL STAGE: First detected in the testis at day 16 and
CC       was reached to the adult level by day 30 after birth.
CC   -!- SIMILARITY: Contains 1 disintegrin domain.
CC   -!- SIMILARITY: Contains 1 EGF-like domain.
CC   -!- SIMILARITY: Contains 1 peptidase M12B domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH60983.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=AAN03858.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC   -!- GENE_FAMILY: HOG000230883 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000037437;ENSMUST00000041257;ENSMUSP00000046737.
DR   EMBL; AF513715; - ;
DR   EMBL; AK005759; - ;
DR   EMBL; BC060983; - ;
DR   UniProtKB/Swiss-Prot; Q8K410; Q6P901; Q8BJ80; -.
DR   EMBL; AK005759; BAC25124.1; -; mRNA.
DR   EMBL; BC060983; AAH60983.1; ALT_INIT; mRNA.
DR   EMBL; AF513715; AAN03858.1; ALT_INIT; mRNA.
DR   IPI; IPI00403257; -.
DR   IPI; IPI00988988; -.
DR   RefSeq; NP_700446.2; NM_153397.2.
DR   UniGene; Mm.269223; -.
DR   ProteinModelPortal; Q8K410; -.
DR   SMR; Q8K410; 182-667.
DR   MEROPS; M12.960; -.
DR   PhosphoSite; Q8K410; -.
DR   PRIDE; Q8K410; -.
DR   Ensembl; ENSMUST00000119720; ENSMUSP00000113076; ENSMUSG00000037437.
DR   Ensembl; ENSMUST00000121438; ENSMUSP00000113627; ENSMUSG00000037437.
DR   GeneID; 353188; -.
DR   KEGG; mmu:353188; -.
DR   UCSC; uc009lfh.2; mouse.
DR   UCSC; uc009lfi.2; mouse.
DR   CTD; 203102; -.
DR   MGI; MGI:2653822; Adam32.
DR   eggNOG; maNOG15391; -.
DR   GeneTree; ENSGT00590000082741; -.
DR   InParanoid; Q8K410; -.
DR   OrthoDB; EOG49CQ78; -.
DR   NextBio; 400335; -.
DR   ArrayExpress; Q8K410; -.
DR   Bgee; Q8K410; -.
DR   CleanEx; MM_ADAM32; -.
DR   Genevestigator; Q8K410; -.
DR   GermOnline; ENSMUSG00000037437; Mus musculus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR001762; Blood-coag_inhib_Disintegrin.
DR   InterPro; IPR006210; EGF-like.
DR   InterPro; IPR013032; EGF-like_reg_CS.
DR   InterPro; IPR000742; EGF_3.
DR   InterPro; IPR024079; MetalloPept_cat_dom.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   Gene3D; G3DSA:4.10.70.10; Blood-coag_inhib_Disintegrin; 1.
DR   Gene3D; G3DSA:3.40.390.10; G3DSA:3.40.390.10; 1.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SMART; SM00181; EGF; 1.
DR   SUPFAM; SSF57552; Disintegrin; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; FALSE_NEG.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS00022; EGF_1; FALSE_NEG.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   HOGENOMDNA; MOUSE8.PE389; -.
KW   ENSMUSG000000374375old_1320000031; ENSMUSP000000467371old_1320000031;
KW   AF513715; AK005759; BC060983;
KW   Alternative splicing; Cleavage on pair of basic residues;
KW   Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein;
KW   Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   750 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLHTLLLLLL AELGALLASG PESQSSFLEI IFPEKIEDKT HSEEQISYII PINKKQYTVH
     LQKRYFLTNR FMVYMYNQGS TSFHSPNIPA QCYYQGHIKG YPNSVATLST CSGLRGFLQF
     ENVSYGIEPL QSAFTSQHIV YKLGNKEKEL IFNKNSRNIE MPTNYGILIN KKPKSPFKNL
     FPLYLEMSIV VDKALYDYLG SDSNIVTNKI IEIISLINSV FAQLKVTIVL SSLELWSDKN
     KIPTVGEADE LLHKFLEWKQ AYLTLRPHDV AYLFIYNEYP NYMGATYPGK MCTAHYSAGI
     TMYPKDMTLE AFSVILTQML GLSLGISYDE PEKCYCSESI CIMNPRAMQY GGVKSFSNCS
     LNDFEHFKSN EGAKCLQNKP QMQRTAAAVC GNGKVEGDEI CDCGSEAECG PDSCCEPNRC
     VLKAGRACDS KSPSSTCCKN CQFLPEKHQC RPEKHLYCDI PEVCNGSSGN CPPDVTINNG
     HVCKESGTIC YNGDCPDLDR VCESIYGAGS VNAPFACYEE IQGQNDRFGN CGKDNRNRYV
     FCGWRNLICG RLICTYPTRM PYNPPNNSTA SVIYAFVRDK VCITVDFGSS VKEDPLRVAN
     GATCDLDRIC LNGVCVESRF LRDQSKTCSS KCHGNGVCNS HGVCHCNAGY SPPNCQYPTT
     KRSASLWSGK HDLPMERASK NQEKKWLLSL YIVLIILASV FLIGTGWKGL KQCGSKEEES
     MSSESKSEDS TYTYVSRSTS ETSSMTSTSS
//

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