(data stored in ACNUC30567 zone)

HOGENOM: MOUSE8_PE390

ID   MOUSE8_PE390                         STANDARD;      PRT;   677 AA.
AC   MOUSE8_PE390; Q8K410; Q6P901; Q8BJ80;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Disintegrin and metalloproteinase domain-containing protein
DE   32; Short=ADAM 32;Flags: Precursor; (MOUSE8.PE390).
GN   Name=Adam32;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE8.PE390.
CC       Mus musculus chromosome 8 NCBIM37  sequence 1..131738871 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:ADA32_MOUSE
CC   -!- FUNCTION: May play a role in sperm development and fertilization
CC       This is a non-catalytic metalloprotease-like protein.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8K410-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8K410-2; Sequence=VSP_012052;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Highly expressed in the testis and weakly
CC       expressed in the epididymis, brain and heart.
CC   -!- DEVELOPMENTAL STAGE: First detected in the testis at day 16 and
CC       was reached to the adult level by day 30 after birth.
CC   -!- SIMILARITY: Contains 1 disintegrin domain.
CC   -!- SIMILARITY: Contains 1 EGF-like domain.
CC   -!- SIMILARITY: Contains 1 peptidase M12B domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH60983.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=AAN03858.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC   -!- GENE_FAMILY: HOG000230883 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000037437;ENSMUST00000110649;ENSMUSP00000106279.
DR   EMBL; AF513715; - ;
DR   EMBL; AK005759; - ;
DR   EMBL; BC060983; - ;
DR   UniProtKB/Swiss-Prot; Q8K410; Q6P901; Q8BJ80; -.
DR   EMBL; AK005759; BAC25124.1; -; mRNA.
DR   EMBL; BC060983; AAH60983.1; ALT_INIT; mRNA.
DR   EMBL; AF513715; AAN03858.1; ALT_INIT; mRNA.
DR   IPI; IPI00403257; -.
DR   IPI; IPI00988988; -.
DR   RefSeq; NP_700446.2; NM_153397.2.
DR   UniGene; Mm.269223; -.
DR   ProteinModelPortal; Q8K410; -.
DR   SMR; Q8K410; 182-667.
DR   MEROPS; M12.960; -.
DR   PhosphoSite; Q8K410; -.
DR   PRIDE; Q8K410; -.
DR   Ensembl; ENSMUST00000119720; ENSMUSP00000113076; ENSMUSG00000037437.
DR   Ensembl; ENSMUST00000121438; ENSMUSP00000113627; ENSMUSG00000037437.
DR   GeneID; 353188; -.
DR   KEGG; mmu:353188; -.
DR   UCSC; uc009lfh.2; mouse.
DR   UCSC; uc009lfi.2; mouse.
DR   CTD; 203102; -.
DR   MGI; MGI:2653822; Adam32.
DR   eggNOG; maNOG15391; -.
DR   GeneTree; ENSGT00590000082741; -.
DR   InParanoid; Q8K410; -.
DR   OrthoDB; EOG49CQ78; -.
DR   NextBio; 400335; -.
DR   ArrayExpress; Q8K410; -.
DR   Bgee; Q8K410; -.
DR   CleanEx; MM_ADAM32; -.
DR   Genevestigator; Q8K410; -.
DR   GermOnline; ENSMUSG00000037437; Mus musculus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR001762; Blood-coag_inhib_Disintegrin.
DR   InterPro; IPR006210; EGF-like.
DR   InterPro; IPR013032; EGF-like_reg_CS.
DR   InterPro; IPR000742; EGF_3.
DR   InterPro; IPR024079; MetalloPept_cat_dom.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   Gene3D; G3DSA:4.10.70.10; Blood-coag_inhib_Disintegrin; 1.
DR   Gene3D; G3DSA:3.40.390.10; G3DSA:3.40.390.10; 1.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SMART; SM00181; EGF; 1.
DR   SUPFAM; SSF57552; Disintegrin; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; FALSE_NEG.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS00022; EGF_1; FALSE_NEG.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   HOGENOMDNA; MOUSE8.PE390; -.
KW   ENSMUSG000000374375old_1320000031; ENSMUSP000001062791old_1320000031;
KW   AF513715; AK005759; BC060983;
KW   Alternative splicing; Cleavage on pair of basic residues;
KW   Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein;
KW   Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   677 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLGAMLHTLL LLLLAELGAL LASGPESQSS FLEIIFPEKI EDKTHSEEQI SYIIPINKKQ
     YTVHLQKRYF LTNRFMVYMY NQGSTSFHSP NIPAQCYYQG HIKGYPNSVA TLSTCSGLRG
     FLQFENVSYG IEPLQSAFTS QHIVYKLGNK EKELIFNKNS RNIEMPTNYG ILINKKPKSP
     FKNLFPLYLE MSIVVDKALY DYLGSDSNIV TNKIIEIISL INSVFAQLKV TIVLSSLELW
     SDKNKIPTVG EADELLHKFL EWKQAYLTLR PHDVAYLFIY NEYPNYMGAT YPGKMCTAHY
     SAGITMYPKD MTLEAFSVIL TQMLGLSLGI SYDEPEKCYC SESICIMNPR AMQYGGVKSF
     SNCSLNDFEH FKSNEGAKCL QNKPQMQRTA AAVCGNGKVE GDEICDCGSE AECGPDSCCE
     PNRCVLKAGR ACDSKSPSST CCKNCQFLPE KHQCRPEKHL YCDIPEVCNG SSGNCPPDVT
     INNGHVCKES GTICYNGDCP DLDRVCESIY GAGSVNAPFA CYEEIQGQND RFGNCGKDNR
     NRYVFCGWRN LICGRLICTY PTRMPYNPPN NSTASVIYAF VRDKVCITVD FGSSVKEDPL
     RVANGATCDL DRICLNGVCV ESRFLRDQSK TCSSKCHGNG KQIRRQHLHV CQQVSSLKDG
     VKRHVENEHH NFQPIVF
//

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