(data stored in ACNUC30567 zone)

HOGENOM: MOUSE8_PE595

ID   MOUSE8_PE595                         STANDARD;      PRT;   697 AA.
AC   MOUSE8_PE595; Q9R158;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Disintegrin and metalloproteinase domain-containing protein
DE   26A; Short=ADAM 26A; EC=3.4.24 -;AltName: Full=Testase-3;Flags:
DE   Precursor; (MOUSE8.PE595).
GN   Name=Adam26a; Synonyms=Adam26;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE8.PE595.
CC       Mus musculus chromosome 8 NCBIM37  sequence 1..131738871 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:AD26A_MOUSE
CC   -!- FUNCTION: Sperm surface membrane protein that may be involved in
CC       spermatogenesis and fertilization.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- TISSUE SPECIFICITY: Expressed specifically in testis.
CC   -!- DEVELOPMENTAL STAGE: Adult levels are reached by day 20 after
CC       birth.
CC   -!- DOMAIN: The conserved cysteine present in the cysteine-switch
CC       motif binds the catalytic zinc ion, thus inhibiting the enzyme.
CC       The dissociation of the cysteine from the zinc ion upon the
CC       activation-peptide release activates the enzyme.
CC   -!- SIMILARITY: Contains 1 disintegrin domain.
CC   -!- SIMILARITY: Contains 1 EGF-like domain.
CC   -!- SIMILARITY: Contains 1 peptidase M12B domain.
CC   -!- GENE_FAMILY: HOG000230883 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000048516;ENSMUST00000049577;ENSMUSP00000058256.
DR   EMBL; AF167404; - ;
DR   EMBL; AK015043; - ;
DR   EMBL; AK029756; - ;
DR   UniProtKB/Swiss-Prot; Q9R158; -.
DR   EMBL; AF167404; AAD48843.1; -; mRNA.
DR   IPI; IPI00128144; -.
DR   RefSeq; NP_034215.2; NM_010085.2.
DR   UniGene; Mm.334510; -.
DR   ProteinModelPortal; Q9R158; -.
DR   SMR; Q9R158; 189-655.
DR   MEROPS; M12.229; -.
DR   PRIDE; Q9R158; -.
DR   GeneID; 13525; -.
DR   KEGG; mmu:13525; -.
DR   UCSC; uc009loe.1; mouse.
DR   CTD; 13525; -.
DR   MGI; MGI:105985; Adam26a.
DR   GeneTree; ENSGT00590000082741; -.
DR   InParanoid; Q9R158; -.
DR   OrthoDB; EOG4XWFX8; -.
DR   ArrayExpress; Q9R158; -.
DR   Bgee; Q9R158; -.
DR   Genevestigator; Q9R158; -.
DR   GermOnline; ENSMUSG00000048516; Mus musculus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR001762; Blood-coag_inhib_Disintegrin.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR024079; MetalloPept_cat_dom.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   Gene3D; G3DSA:4.10.70.10; Blood-coag_inhib_Disintegrin; 1.
DR   Gene3D; G3DSA:3.40.390.10; G3DSA:3.40.390.10; 1.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; Disintegrin; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00546; CYSTEINE_SWITCH; FALSE_NEG.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS00022; EGF_1; FALSE_NEG.
DR   PROSITE; PS01186; EGF_2; FALSE_NEG.
DR   PROSITE; PS50026; EGF_3; FALSE_NEG.
DR   PROSITE; PS00142; ZINC_PROTEASE; 1.
DR   HOGENOMDNA; MOUSE8.PE595; -.
KW   ENSMUSG000000485165old_1320000031; ENSMUSP000000582561old_1320000031;
KW   Q8BMR4_MOUSE; Q9CUQ4_MOUSE; AF167404; AK015043; AK029756;
KW   Complete proteome; Developmental protein; Differentiation;
KW   Disulfide bond; EGF-like domain; Glycoprotein; Hydrolase; Membrane;
KW   Metal-binding; Metalloprotease; Protease; Reference proteome; Signal;
KW   Spermatogenesis; Transmembrane; Transmembrane helix; Zinc; Zymogen.
SQ   SEQUENCE   697 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MFLKFCLWTM FFFSAWSPIG HAKYSSLLEV VTPLRVTVTR GNNISPGWLS YSLNIGGQRH
     IITMKPKKNL ISRNFLLFTY SDQGDLLEQH HFVQNDCYYH GYVDEDLESP VIVNTCFGSL
     QGTLEINGTS YEIMPKSSTS TFEHLVYKMD SGDSESSPMR CGLSEEETAQ QTKLQESNAP
     TLLQIPYENW WTHHRFIEYF VVLDHKQYVH RNNNITTCIQ DMLQIVNGVN GYYLQIDTDV
     VLTTLEVWNE KNYINVELSI FKVLGDFCTW KQNMFGNRIR HDIIHLLVRQ GYGLYLGLAY
     LADVCTPYNC GVSSVLSDVM SDMAHIVAHE MGHNFGMKHD GIGCTCGLKD CLMAPYKTNS
     PKFSNCSYEE MYSVVTKRSC LYDIPEALVT NLTVCGNKVV EEGEQCDCGN SESCLQDPCC
     SSDCVLKPGA QCAFGLCCKN CQFLKAGTVC RKEKNECDLP EWCNGTSAEC PGDVYKADGI
     PCSGEGYCYK MECHQRDEQC RKIFGNGSRS ADEICYMEMN RQGDRFGNCG NDSSTYRTCQ
     IADVLCGQIQ CENVIQLPQR RNHETVHYTH FSNITCWTMD YHFGITIDDI GAVSDGTAYA
     PDHICVDRKC VSKSVLVSNC SPQLYHMQGI CNNKQHCHCG VTWKPPDCQK RGHGGSIDSG
     PPPLPLSHSK WIVYILIVLD VCIVIIIYLF SFYKLSK
//

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