(data stored in ACNUC8465 zone)

HOGENOM: MOUSE8_PE62

ID   MOUSE8_PE62                          STANDARD;      PRT;   419 AA.
AC   MOUSE8_PE62;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 7;
DE   Short=MAP kinase kinase 7; Short=MAPKK 7; EC=2.7.12 2;AltName:
DE   Full=JNK-activating kinase 2;AltName: Full=MAPK/ERK kinase 7; Short=MEK
DE   7;AltName: Full=c-Jun N-terminal kinase kinase 2; Short=JNK kinase 2;
DE   Short=JNKK 2; (MOUSE8.PE62).
GN   Name=Map2k7; Synonyms=Mkk7;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE8.PE62.
CC       Mus musculus chromosome 8 NCBIM37  sequence 1..131738871 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K7_MOUSE
CC   -!- FUNCTION: Stress activated, dual specificity kinase that activates
CC       the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- COFACTOR: Magnesium.
CC   -!- ENZYME REGULATION: Activated by phosphorylation by specific MAP
CC       kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3,
CC       MAP3K11/MLK3 and MAP3K12/DLK. Isoforms 3 and 4 have lower basal
CC       activity but a higher level of inducible activation, than isoforms
CC       2, 6, 7 and 8.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=8;
CC       Name=1;
CC         IsoId=Q8CE90-1; Sequence=Displayed;
CC         Note=No experimental confirmation available;
CC       Name=2; Synonyms=a, beta 1;
CC         IsoId=Q8CE90-2; Sequence=VSP_052266, VSP_052268, VSP_052269;
CC       Name=3; Synonyms=alpha 2;
CC         IsoId=Q8CE90-3; Sequence=VSP_052265, VSP_052270, VSP_052271;
CC       Name=4; Synonyms=alpha 1;
CC         IsoId=Q8CE90-4; Sequence=VSP_052265, VSP_052268, VSP_052269;
CC       Name=5; Synonyms=b;
CC         IsoId=Q8CE90-5; Sequence=VSP_052264, VSP_052267, VSP_052268,
CC                                  VSP_052269;
CC         Note=No experimental confirmation available;
CC       Name=6; Synonyms=b, gamma 1;
CC         IsoId=Q8CE90-6; Sequence=VSP_052268, VSP_052269;
CC       Name=7; Synonyms=gamma 2;
CC         IsoId=Q8CE90-7; Sequence=VSP_052270, VSP_052271;
CC       Name=8; Synonyms=beta 2;
CC         IsoId=Q8CE90-8; Sequence=VSP_052266, VSP_052270, VSP_052271;
CC   -!- TISSUE SPECIFICITY: Expressed at high levels in brain, lung,
CC       liver, skeletal muscle, kidney, and testis and at lower levels in
CC       the heart and spleen.
CC   -!- DEVELOPMENTAL STAGE: Expressed at high levels in the brain, spinal
CC       cord, eyes, muscle, lungs, vertebrae, and intestine and at lower
CC       levels in the heart and livers at E12.5. At later stages of
CC       embryogenesis (E14.5, E16.5, and E18.5) high levels were found in
CC       the brain, retina, bone marrow, skin, intestine, lung epithelium
CC       and the epithelial layers lining the olfactory cavity and
CC       developing teeth and whiskers.
CC   -!- PTM: Phosphorylated on Ser/Thr residues.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000002948;ENSMUST00000110998;ENSMUSP00000106626.
DR   EMBL; AB005654; - ;
DR   EMBL; AF022112; - ;
DR   EMBL; AF022113; - ;
DR   EMBL; AF026216; - ;
DR   EMBL; AF060943; - ;
DR   EMBL; AF060944; - ;
DR   EMBL; AF060945; - ;
DR   EMBL; AF060946; - ;
DR   EMBL; AF060947; - ;
DR   EMBL; AK028772; - ;
DR   EMBL; AK031137; - ;
DR   EMBL; AK165184; - ;
DR   EMBL; BC070467; - ;
DR   EMBL; U74463; - ;
DR   EMBL; U74464; - ;
DR   EMBL; U93030; - ;
DR   EMBL; U93031; - ;
DR   UniProtKB/Swiss-Prot; Q8CE90; O35406; O35720; O35871; O35872; O54780; O70242; O70243; -.
DR   UniProtKB/Swiss-Prot; Q8BSP1; Q9QWG6; Q9R1Z3; Q9R1Z4; Q9R1Z5; Q9R1Z6; -.
DR   EMBL; AF026216; AAB81848.1; -; mRNA.
DR   EMBL; U74463; AAC53364.1; -; mRNA.
DR   EMBL; U74464; AAC53365.1; -; mRNA.
DR   EMBL; AB005654; BAA24383.1; -; mRNA.
DR   EMBL; AF022112; AAC16274.1; -; mRNA.
DR   EMBL; AF022113; AAC16275.1; -; mRNA.
DR   EMBL; U93030; AAB63447.1; -; mRNA.
DR   EMBL; U93031; AAB63448.1; -; Genomic_DNA.
DR   EMBL; AF060943; AAD15819.1; -; mRNA.
DR   EMBL; AF060944; AAD15820.1; -; mRNA.
DR   EMBL; AF060945; AAD15821.1; -; mRNA.
DR   EMBL; AF060946; AAD15822.1; -; mRNA.
DR   EMBL; AF060947; AAD15823.1; -; mRNA.
DR   EMBL; AK028772; BAC26111.1; -; mRNA.
DR   EMBL; AK031137; BAC27272.1; -; mRNA.
DR   EMBL; AK165184; BAE38066.1; -; mRNA.
DR   EMBL; BC070467; AAH70467.1; -; mRNA.
DR   IPI; IPI00117840; -.
DR   IPI; IPI00228989; -.
DR   IPI; IPI00280475; -.
DR   IPI; IPI00749972; -.
DR   IPI; IPI00816840; -.
DR   IPI; IPI00816864; -.
DR   IPI; IPI00816890; -.
DR   IPI; IPI00816911; -.
DR   RefSeq; NP_001036022.1; NM_001042557.2.
DR   RefSeq; NP_001157644.1; NM_001164172.1.
DR   RefSeq; NP_036074.2; NM_011944.3.
DR   UniGene; Mm.3906; -.
DR   HSSP; P36507; 1S9I.
DR   ProteinModelPortal; Q8CE90; -.
DR   SMR; Q8CE90; 119-418.
DR   IntAct; Q8CE90; 2.
DR   STRING; Q8CE90; -.
DR   PhosphoSite; Q8CE90; -.
DR   PRIDE; Q8CE90; -.
DR   Ensembl; ENSMUST00000003027; ENSMUSP00000003027; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000052385; ENSMUSP00000050752; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000062686; ENSMUSP00000054512; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000110994; ENSMUSP00000106622; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000110995; ENSMUSP00000106623; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000110996; ENSMUSP00000106624; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000110998; ENSMUSP00000106626; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000110999; ENSMUSP00000106627; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000145165; ENSMUSP00000117418; ENSMUSG00000002948.
DR   GeneID; 26400; -.
DR   KEGG; mmu:26400; -.
DR   UCSC; uc009kti.2; mouse.
DR   UCSC; uc009ktj.2; mouse.
DR   UCSC; uc009ktk.2; mouse.
DR   UCSC; uc009ktm.2; mouse.
DR   UCSC; uc009ktn.2; mouse.
DR   CTD; 5609; -.
DR   MGI; MGI:1346871; Map2k7.
DR   eggNOG; roNOG15478; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   InParanoid; Q8CE90; -.
DR   OMA; GVLSQPH; -.
DR   PhylomeDB; Q8CE90; -.
DR   NextBio; 304359; -.
DR   ArrayExpress; Q8CE90; -.
DR   Bgee; Q8CE90; -.
DR   CleanEx; MM_MAP2K7; -.
DR   Genevestigator; Q8CE90; -.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IDA:UniProtKB.
DR   GO; GO:0019903; F:protein phosphatase binding; IPI:BHF-UCL.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0007257; P:activation of JUN kinase activity; IDA:BHF-UCL.
DR   GO; GO:0051403; P:stress-activated MAPK cascade; IDA:UniProtKB.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; MOUSE8.PE62; -.
KW   ENSMUSG000000029485old_1320000031; ENSMUSP000001066261old_1320000031;
KW   AB005654; AF022112; AF022113; AF026216; AF060943; AF060944; AF060945;
KW   AF060947; AK028772; AK031137; AK165184; BC070467; U74463; U74464; U93030;
KW   U93031;
KW   Acetylation; Alternative splicing; ATP-binding; Coiled coil;
KW   Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding;
KW   Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   419 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PTLQLPLAND GGSRSPSSES
     SPQHPTPPTR PRHMLGLPST LFTPRSMESI EIDQKLQEIM KQTGYLTIGG QRYQAEINDL
     ENLGEMGSGT CGQVWKMRFR KTGHIIAVKQ MRRSGNKEEN KRILMDLDVV LKSHDCPYIV
     QCFGTFITNT DVFIAMELMG TCAEKLKKRM QGPIPERILG KMTVAIVKAL YYLKEKHGVI
     HRDVKPSNIL LDERGQIKLC DFGISGRLVD SKAKTRSAGC AAYMAPERID PPDPTKPDYD
     IRADVWSLGI SLVELATGQF PYKNCKTDFE VLTKVLQEEP PLLPGHMGFS GDFQSFVKDC
     LTKDHRKRPK YNKLLEHSFI KHYEILEVDV ASWFKDVMAK TESPRTSGVL SQHHLPFFR
//

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