(data stored in ACNUC8465 zone)

HOGENOM: MOUSE8_PE70

ID   MOUSE8_PE70                          STANDARD;      PRT;   535 AA.
AC   MOUSE8_PE70;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 7;
DE   Short=MAP kinase kinase 7; Short=MAPKK 7; EC=2.7.12 2;AltName:
DE   Full=JNK-activating kinase 2;AltName: Full=MAPK/ERK kinase 7; Short=MEK
DE   7;AltName: Full=c-Jun N-terminal kinase kinase 2; Short=JNK kinase 2;
DE   Short=JNKK 2; (MOUSE8.PE70).
GN   Name=Map2k7; Synonyms=Mkk7;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE8.PE70.
CC       Mus musculus chromosome 8 NCBIM37  sequence 1..131738871 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K7_MOUSE
CC   -!- FUNCTION: Stress activated, dual specificity kinase that activates
CC       the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- COFACTOR: Magnesium.
CC   -!- ENZYME REGULATION: Activated by phosphorylation by specific MAP
CC       kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3,
CC       MAP3K11/MLK3 and MAP3K12/DLK. Isoforms 3 and 4 have lower basal
CC       activity but a higher level of inducible activation, than isoforms
CC       2, 6, 7 and 8.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=8;
CC       Name=1;
CC         IsoId=Q8CE90-1; Sequence=Displayed;
CC         Note=No experimental confirmation available;
CC       Name=2; Synonyms=a, beta 1;
CC         IsoId=Q8CE90-2; Sequence=VSP_052266, VSP_052268, VSP_052269;
CC       Name=3; Synonyms=alpha 2;
CC         IsoId=Q8CE90-3; Sequence=VSP_052265, VSP_052270, VSP_052271;
CC       Name=4; Synonyms=alpha 1;
CC         IsoId=Q8CE90-4; Sequence=VSP_052265, VSP_052268, VSP_052269;
CC       Name=5; Synonyms=b;
CC         IsoId=Q8CE90-5; Sequence=VSP_052264, VSP_052267, VSP_052268,
CC                                  VSP_052269;
CC         Note=No experimental confirmation available;
CC       Name=6; Synonyms=b, gamma 1;
CC         IsoId=Q8CE90-6; Sequence=VSP_052268, VSP_052269;
CC       Name=7; Synonyms=gamma 2;
CC         IsoId=Q8CE90-7; Sequence=VSP_052270, VSP_052271;
CC       Name=8; Synonyms=beta 2;
CC         IsoId=Q8CE90-8; Sequence=VSP_052266, VSP_052270, VSP_052271;
CC   -!- TISSUE SPECIFICITY: Expressed at high levels in brain, lung,
CC       liver, skeletal muscle, kidney, and testis and at lower levels in
CC       the heart and spleen.
CC   -!- DEVELOPMENTAL STAGE: Expressed at high levels in the brain, spinal
CC       cord, eyes, muscle, lungs, vertebrae, and intestine and at lower
CC       levels in the heart and livers at E12.5. At later stages of
CC       embryogenesis (E14.5, E16.5, and E18.5) high levels were found in
CC       the brain, retina, bone marrow, skin, intestine, lung epithelium
CC       and the epithelial layers lining the olfactory cavity and
CC       developing teeth and whiskers.
CC   -!- PTM: Phosphorylated on Ser/Thr residues.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000002948;ENSMUST00000052385;ENSMUSP00000050752.
DR   EMBL; AB005654; - ;
DR   EMBL; AF022112; - ;
DR   EMBL; AF022113; - ;
DR   EMBL; AF026216; - ;
DR   EMBL; AF060943; - ;
DR   EMBL; AF060944; - ;
DR   EMBL; AF060945; - ;
DR   EMBL; AF060946; - ;
DR   EMBL; AF060947; - ;
DR   EMBL; AK028772; - ;
DR   EMBL; AK031137; - ;
DR   EMBL; AK165184; - ;
DR   EMBL; BC070467; - ;
DR   EMBL; U74463; - ;
DR   EMBL; U74464; - ;
DR   EMBL; U93030; - ;
DR   EMBL; U93031; - ;
DR   UniProtKB/Swiss-Prot; Q8CE90; O35406; O35720; O35871; O35872; O54780; O70242; O70243; -.
DR   UniProtKB/Swiss-Prot; Q8BSP1; Q9QWG6; Q9R1Z3; Q9R1Z4; Q9R1Z5; Q9R1Z6; -.
DR   EMBL; AF026216; AAB81848.1; -; mRNA.
DR   EMBL; U74463; AAC53364.1; -; mRNA.
DR   EMBL; U74464; AAC53365.1; -; mRNA.
DR   EMBL; AB005654; BAA24383.1; -; mRNA.
DR   EMBL; AF022112; AAC16274.1; -; mRNA.
DR   EMBL; AF022113; AAC16275.1; -; mRNA.
DR   EMBL; U93030; AAB63447.1; -; mRNA.
DR   EMBL; U93031; AAB63448.1; -; Genomic_DNA.
DR   EMBL; AF060943; AAD15819.1; -; mRNA.
DR   EMBL; AF060944; AAD15820.1; -; mRNA.
DR   EMBL; AF060945; AAD15821.1; -; mRNA.
DR   EMBL; AF060946; AAD15822.1; -; mRNA.
DR   EMBL; AF060947; AAD15823.1; -; mRNA.
DR   EMBL; AK028772; BAC26111.1; -; mRNA.
DR   EMBL; AK031137; BAC27272.1; -; mRNA.
DR   EMBL; AK165184; BAE38066.1; -; mRNA.
DR   EMBL; BC070467; AAH70467.1; -; mRNA.
DR   IPI; IPI00117840; -.
DR   IPI; IPI00228989; -.
DR   IPI; IPI00280475; -.
DR   IPI; IPI00749972; -.
DR   IPI; IPI00816840; -.
DR   IPI; IPI00816864; -.
DR   IPI; IPI00816890; -.
DR   IPI; IPI00816911; -.
DR   RefSeq; NP_001036022.1; NM_001042557.2.
DR   RefSeq; NP_001157644.1; NM_001164172.1.
DR   RefSeq; NP_036074.2; NM_011944.3.
DR   UniGene; Mm.3906; -.
DR   HSSP; P36507; 1S9I.
DR   ProteinModelPortal; Q8CE90; -.
DR   SMR; Q8CE90; 119-418.
DR   IntAct; Q8CE90; 2.
DR   STRING; Q8CE90; -.
DR   PhosphoSite; Q8CE90; -.
DR   PRIDE; Q8CE90; -.
DR   Ensembl; ENSMUST00000003027; ENSMUSP00000003027; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000052385; ENSMUSP00000050752; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000062686; ENSMUSP00000054512; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000110994; ENSMUSP00000106622; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000110995; ENSMUSP00000106623; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000110996; ENSMUSP00000106624; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000110998; ENSMUSP00000106626; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000110999; ENSMUSP00000106627; ENSMUSG00000002948.
DR   Ensembl; ENSMUST00000145165; ENSMUSP00000117418; ENSMUSG00000002948.
DR   GeneID; 26400; -.
DR   KEGG; mmu:26400; -.
DR   UCSC; uc009kti.2; mouse.
DR   UCSC; uc009ktj.2; mouse.
DR   UCSC; uc009ktk.2; mouse.
DR   UCSC; uc009ktm.2; mouse.
DR   UCSC; uc009ktn.2; mouse.
DR   CTD; 5609; -.
DR   MGI; MGI:1346871; Map2k7.
DR   eggNOG; roNOG15478; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   InParanoid; Q8CE90; -.
DR   OMA; GVLSQPH; -.
DR   PhylomeDB; Q8CE90; -.
DR   NextBio; 304359; -.
DR   ArrayExpress; Q8CE90; -.
DR   Bgee; Q8CE90; -.
DR   CleanEx; MM_MAP2K7; -.
DR   Genevestigator; Q8CE90; -.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IDA:UniProtKB.
DR   GO; GO:0019903; F:protein phosphatase binding; IPI:BHF-UCL.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0007257; P:activation of JUN kinase activity; IDA:BHF-UCL.
DR   GO; GO:0051403; P:stress-activated MAPK cascade; IDA:UniProtKB.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; MOUSE8.PE70; -.
KW   ENSMUSG000000029485old_1320000031; ENSMUSP000000507521old_1320000031;
KW   AB005654; AF022112; AF022113; AF026216; AF060943; AF060944; AF060945;
KW   AF060947; AK028772; AK031137; AK165184; BC070467; U74463; U74464; U93030;
KW   U93031;
KW   Acetylation; Alternative splicing; ATP-binding; Coiled coil;
KW   Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding;
KW   Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   535 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PIIVITLSPA PAPSQRAALQ
     LPLANDGGSR SPSSESSPQH PTPPTRPRHM LGLPSTLFTP RSMESIEIDQ KLQEIMKQTG
     YLTIGGQRYQ AEINDLENLG EMGSGTCGQV WKMRFRKTGH IIAVKQMRRS GNKEENKRIL
     MDLDVVLKSH DCPYIVQCFG TFITNTDVFI AMELMGTCAE KLKKRMQGPI PERILGKMTV
     AIVKALYYLK EKHGVIHRDV KPSNILLDER GQIKLCDFGI SGRLVDSKAK TRSAGCAAYM
     APERIDPPDP TKPDYDIRAD VWSLGISLVE LATGQFPYKN CKTDFEVLTK VLQEEPPLLP
     GHMGFSGDFQ SFVKDCLTKD HRKRPKYNKL LEHSFIKHYE ILEVDVASWF KDVMAKTESP
     RTSGVLSQHH LPFFSTSVTW GAWPLAAQTP FQSGVIRCRG RVPSPRRATG GSGGQPCVCA
     GGPGPSFTEM GPSPSPMLSN TFFTPDPGAC PGASTWGLPR RRLCQLLTTS TPGCC
//

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