(data stored in ACNUC8465 zone)

HOGENOM: MOUSE9_PE1268

ID   MOUSE9_PE1268                        STANDARD;      PRT;   448 AA.
AC   MOUSE9_PE1268; Q9WVS7; Q8CFM3; Q8K360; Q9D222;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 5;
DE   Short=MAP kinase kinase 5; Short=MAPKK 5; EC=2.7.12 2;AltName:
DE   Full=MAPK/ERK kinase 5; Short=MEK 5; (MOUSE9.PE1268).
GN   Name=Map2k5; Synonyms=Mek5, Mkk5, Prkmk5;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE9.PE1268.
CC       Mus musculus chromosome 9 NCBIM37  sequence 1..124076172 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K5_MOUSE
CC   -!- FUNCTION: Acts as a scaffold for the formation of a ternary
CC       MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this
CC       pathway appear to play a critical role in protecting cells from
CC       stress-induced apopotosis, neuronal survival and cardiac
CC       development and angiogenesis.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- COFACTOR: Magnesium.
CC   -!- SUBUNIT: Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex
CC       with SQSTM1 and PRKCZ or PRKCI.
CC   -!- INTERACTION:
CC       Q61083:Map3k2; NbExp=4; IntAct=EBI-446144, EBI-446134;
CC       Q61084:Map3k3; NbExp=15; IntAct=EBI-446144, EBI-446250;
CC       P28656:Nap1l1; NbExp=20; IntAct=EBI-446144, EBI-645055;
CC       Q64337:Sqstm1; NbExp=3; IntAct=EBI-446144, EBI-645025;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q9WVS7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9WVS7-2; Sequence=VSP_015840;
CC       Name=3;
CC         IsoId=Q9WVS7-3; Sequence=VSP_015838, VSP_015839;
CC       Name=4;
CC         IsoId=Q9WVS7-4; Sequence=VSP_015836, VSP_015837;
CC   -!- DOMAIN: Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues
CC       of the OPR domain. This domain also mediates interactions with
CC       SQSTM1 and PARD6A.
CC   -!- PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase
CC       kinases (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 OPR domain.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000058444;ENSMUST00000034920;ENSMUSP00000034920.
DR   EMBL; AB019374; - ;
DR   EMBL; AK020716; - ;
DR   EMBL; AK166137; - ;
DR   EMBL; BC013697; - ;
DR   EMBL; BC028260; - ;
DR   UniProtKB/Swiss-Prot; Q9WVS7; Q8CFM3; Q8K360; Q9D222; -.
DR   EMBL; AB019374; BAA82040.1; -; mRNA.
DR   EMBL; AK020716; BAB32187.1; -; mRNA.
DR   EMBL; BC013697; AAH13697.1; -; mRNA.
DR   EMBL; BC028260; AAH28260.1; -; mRNA.
DR   IPI; IPI00126447; -.
DR   IPI; IPI00134154; -.
DR   IPI; IPI00653118; -.
DR   IPI; IPI00653587; -.
DR   RefSeq; NP_035970.1; NM_011840.2.
DR   UniGene; Mm.325746; -.
DR   PDB; 1WI0; NMR; -; A=8-107.
DR   PDBsum; 1WI0; -.
DR   ProteinModelPortal; Q9WVS7; -.
DR   SMR; Q9WVS7; 16-108, 159-438.
DR   IntAct; Q9WVS7; 10.
DR   STRING; Q9WVS7; -.
DR   PhosphoSite; Q9WVS7; -.
DR   PRIDE; Q9WVS7; -.
DR   Ensembl; ENSMUST00000034920; ENSMUSP00000034920; ENSMUSG00000058444.
DR   Ensembl; ENSMUST00000113943; ENSMUSP00000109576; ENSMUSG00000058444.
DR   Ensembl; ENSMUST00000113944; ENSMUSP00000109577; ENSMUSG00000058444.
DR   Ensembl; ENSMUST00000113945; ENSMUSP00000109578; ENSMUSG00000058444.
DR   GeneID; 23938; -.
DR   KEGG; mmu:23938; -.
DR   UCSC; uc009qaw.1; mouse.
DR   UCSC; uc012guv.1; mouse.
DR   CTD; 5607; -.
DR   MGI; MGI:1346345; Map2k5.
DR   GeneTree; ENSGT00570000078767; -.
DR   InParanoid; Q9WVS7; -.
DR   OMA; HAMENQV; -.
DR   OrthoDB; EOG49GKGK; -.
DR   PhylomeDB; Q9WVS7; -.
DR   NextBio; 303741; -.
DR   ArrayExpress; Q9WVS7; -.
DR   Bgee; Q9WVS7; -.
DR   CleanEx; MM_MAP2K5; -.
DR   Genevestigator; Q9WVS7; -.
DR   GermOnline; ENSMUSG00000058444; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IDA:MGI.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0007507; P:heart development; IMP:MGI.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000270; OPR_PB1.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00564; PB1; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00666; PB1; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; MOUSE9.PE1268; -.
KW   ENSMUSG000000584445old_1320000031; ENSMUSP000000349201old_1320000031;
KW   Q3TM51_MOUSE; AB019374; AK020716; AK166137; BC013697; BC028260;
KW   3D-structure; Alternative splicing; ATP-binding; Complete proteome;
KW   Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Serine/threonine-protein kinase;
KW   Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   448 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLWLALGPFC AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF
     EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL
     KVNTRAGPSQ HTSPVVSDSL PSNSLKKSSA ELRKILANGQ MNEQDIRYRD TLGHGNGGTV
     YKAHHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC
     TEFMDGGSLD VYRKIPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTGGQVKLC
     DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ
     KNQGSLMPLQ LLQCIVDEDS PVLPLGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV
     QFNDGNSTVV SMWVCRALEE RRSQQGPP
//

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