(data stored in ACNUC8465 zone)

HOGENOM: MOUSE9_PE1291

ID   MOUSE9_PE1291                        STANDARD;      PRT;   393 AA.
AC   MOUSE9_PE1291; P31938;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 1;
DE   Short=MAP kinase kinase 1; Short=MAPKK 1; EC=2.7.12 2;AltName: Full=ERK
DE   activator kinase 1;AltName: Full=MAPK/ERK kinase 1; Short=MEK 1;
DE   (MOUSE9.PE1291).
GN   Name=Map2k1; Synonyms=Mek1, Prkmk1;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE9.PE1291.
CC       Mus musculus chromosome 9 NCBIM37  sequence 1..124076172 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K1_MOUSE
CC   -!- FUNCTION: Catalyzes the concomitant phosphorylation of a threonine
CC       and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP
CC       kinases. Activates ERK1 and ERK2 MAP kinases.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Inhibited by serine/threonine phosphatase 2A.
CC   -!- SUBUNIT: Interacts with MORG1. Interacts with ARRB2. Found in a
CC       complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14 (By
CC       similarity).
CC   -!- PTM: MAPKK is itself dependent on Ser/Thr phosphorylation for
CC       activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000004936;ENSMUST00000005066;ENSMUSP00000005066.
DR   EMBL; AB041567; - ;
DR   EMBL; AK146233; - ;
DR   EMBL; AK146931; - ;
DR   EMBL; AK154793; - ;
DR   EMBL; AK165664; - ;
DR   EMBL; AK165894; - ;
DR   EMBL; AK167336; - ;
DR   EMBL; AY902345; - ;
DR   EMBL; BC054754; - ;
DR   EMBL; CH466522; - ;
DR   EMBL; L02526; - ;
DR   UniProtKB/Swiss-Prot; P31938; -.
DR   EMBL; L02526; AAA39523.1; -; mRNA.
DR   EMBL; BC054754; AAH54754.1; -; mRNA.
DR   IPI; IPI00466610; -.
DR   PIR; I59571; I59571.
DR   RefSeq; NP_032953.1; NM_008927.3.
DR   UniGene; Mm.248907; -.
DR   ProteinModelPortal; P31938; -.
DR   SMR; P31938; 39-381.
DR   DIP; DIP-467N; -.
DR   IntAct; P31938; 3.
DR   STRING; P31938; -.
DR   PhosphoSite; P31938; -.
DR   UCD-2DPAGE; P31938; -.
DR   PRIDE; P31938; -.
DR   Ensembl; ENSMUST00000005066; ENSMUSP00000005066; ENSMUSG00000004936.
DR   GeneID; 26395; -.
DR   KEGG; mmu:26395; -.
DR   CTD; 5604; -.
DR   MGI; MGI:1346866; Map2k1.
DR   eggNOG; roNOG05418; -.
DR   InParanoid; P31938; -.
DR   OMA; DIAGWVC; -.
DR   OrthoDB; EOG4SF965; -.
DR   PhylomeDB; P31938; -.
DR   BRENDA; 2.7.12.2; 3474.
DR   NextBio; 304339; -.
DR   ArrayExpress; P31938; -.
DR   Bgee; P31938; -.
DR   CleanEx; MM_MAP2K1; -.
DR   Genevestigator; P31938; -.
DR   GermOnline; ENSMUSG00000004936; Mus musculus.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IMP:MGI.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004728; F:receptor signaling protein tyrosine phosphatase activity; IMP:MGI.
DR   GO; GO:0000187; P:activation of MAPK activity; IMP:MGI.
DR   GO; GO:0048870; P:cell motility; IMP:MGI.
DR   GO; GO:0030216; P:keratinocyte differentiation; IMP:MGI.
DR   GO; GO:0060711; P:labyrinthine layer development; IMP:MGI.
DR   GO; GO:0060674; P:placenta blood vessel development; IMP:MGI.
DR   GO; GO:0045597; P:positive regulation of cell differentiation; IDA:MGI.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; MOUSE9.PE1291; -.
KW   ENSMUSG000000049365old_1320000031; ENSMUSP000000050661old_1320000031;
KW   Q3TMJ8_MOUSE; Q3TMW4_MOUSE; Q3U3F4_MOUSE; Q3UK05_MOUSE; Q9JJE1_MOUSE;
KW   AK146233; AK146931; AK154793; AK165664; AK165894; AK167336; AY902345;
KW   CH466522; L02526;
KW   ATP-binding; Complete proteome; Direct protein sequencing; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   393 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV
     GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE
     CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL
     REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY
     SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE LELLFGCHVE GDAAETPPRP RTPGRPLSSY
     GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA DLKQLMVHAF
     IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA ASI
//

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